scholarly journals Real-world visual acuity outcomes between ranibizumab and aflibercept in treatment of neovascular AMD in a large US data set

Eye ◽  
2017 ◽  
Vol 31 (12) ◽  
pp. 1697-1706 ◽  
Author(s):  
A Lotery ◽  
R Griner ◽  
A Ferreira ◽  
F Milnes ◽  
P Dugel
Keyword(s):  
Visual Acuity ◽  
Real World ◽  
Neovascular Amd ◽  
Data Set

scholarly journals Eyes that Do Not Meet the Eligibility Criteria of Clinical Trials on Age-Related Macular Degeneration: Proportion of the Real-World Patient Population and Reasons for Exclusion

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jae Hui Kim ◽  
Jong Woo Kim ◽  
Chul Gu Kim
Keyword(s):  
Clinical Trials ◽  
Visual Acuity ◽  
Real World ◽  
Age Related Macular Degeneration ◽  
Subretinal Hemorrhage ◽  
Neovascular Amd ◽  
Eligibility Criteria ◽  
Type 3 Neovascularization ◽  
Age Related ◽  
Type 3

Background. To evaluate the proportion of eyes that do not meet the eligibility criteria of clinical trials on neovascular age-related macular degeneration (AMD) and the reasons for exclusion. Methods. This retrospective, observational study included 512 eyes of 463 patients diagnosed with treatment-naïve neovascular AMD. The proportion of eyes that did not meet the eligibility criteria of the Vascular Endothelial Growth Factor Trap-Eye: Investigation of Efficacy and Safety in Wet AMD (VIEW) studies were evaluated. The two most common reasons for exclusion were also evaluated in each subtype of neovascular AMD (typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), and type 3 neovascularization). Results. Among the 512 eyes, 229 (44.7%) did not meet the eligibility criteria. In all the included eyes, the most common reasons for exclusion were good or poor visual acuity (169 eyes, 33.0%), followed by the presence of subretinal hemorrhage (47 eyes, 9.5%). Moreover, good or poor visual acuity was the most common reason for exclusion in all three subtypes of neovascular AMD. The second most common reason was a fovea-involving scar or fibrosis in typical neovascular AMD, subretinal hemorrhage in PCV, and other vascular diseases affecting the retina in type 3 neovascularization. Conclusions. Among the included cases, 44.7% did not meet the eligibility criteria for VIEW study, suggesting that the conclusion derived from clinical trials may not directly reflect the real-world outcomes. Additionally, the reasons for ineligibility differed among the different subtypes of neovascular AMD.

scholarly journals United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group: report 4, real-world data on the impact of deprivation on the presentation of diabetic eye disease at hospital services

2018 ◽  
Vol 103 (6) ◽  
pp. 837-843 ◽  
Author(s):  
Alastair K Denniston ◽  
Aaron Y Lee ◽  
Cecilia S Lee ◽  
David P Crabb ◽  
Clare Bailey ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Medical Record ◽  
Electronic Medical Record ◽  
Real World ◽  
Eye Disease ◽  
Inclusion Criteria ◽  
Data Set ◽  
Diabetic Eye Disease ◽  
The Impact

AimTo assess the impact of deprivation on diabetic retinopathy presentation and related treatment interventions, as observed within the UK hospital eye service.MethodsThis is a multicentre, national diabetic retinopathy database study with anonymised data extraction across 22 centres from an electronic medical record system. The following were the inclusion criteria: all patients with diabetes and a recorded, structured diabetic retinopathy grade. The minimum data set included, for baseline, age and Index of Multiple Deprivation, based on residential postcode; and for all time points, visual acuity, ETDRS grading of retinopathy and maculopathy, and interventions (laser, intravitreal therapies and surgery). The main  outcome measures were (1) visual acuity and binocular visual state, and (2) presence of sight-threatening complications and need for early treatment.Results79 775 patients met the inclusion criteria. Deprivation was associated with later presentation in patients with diabetic eye disease: the OR of being sight-impaired at entry into the hospital eye service (defined as 6/18 to better than 3/60 in the better seeing eye) was 1.29 (95% CI 1.20 to 1.39) for the most deprived decile vs 0.77 (95% CI 0.70 to 0.86) for the least deprived decile; the OR for being severely sight-impaired (3/60 or worse in the better seeing eye) was 1.17 (95% CI 0.90 to 1.55) for the most deprived decile vs 0.88 (95% CI 0.61 to 1.27) for the least deprived decile (reference=fifth decile in all cases). There is also variation in sight-threatening complications at presentation and treatment undertaken: the least deprived deciles had lower chance of having a tractional retinal detachment (OR=0.48 and 0.58 for deciles 9 and 10, 95% CI 0.24 to 0.90 and 0.29 to 1.09, respectively); in terms of accessing treatment, the rate of having a vitrectomy was lowest in the most deprived cohort (OR=0.34, 95% CI 0.19 to 0.58).ConclusionsThis large real-world study suggests that first presentation at a hospital eye clinic with visual loss or sight-threatening diabetic eye disease is associated with deprivation. These initial hospital visits represent the first opportunities to receive treatment and to formally engage with support services. Such patients are more likely to be sight-impaired or severely sight-impaired at presentation, and may need additional resources to engage with the hospital eye services over complex treatment schedules.

scholarly journals The UK Neovascular AMD Database Report 3: inter-centre variation in visual acuity outcomes and establishing real-world measures of care

Eye ◽  
2016 ◽  
Vol 30 (11) ◽  
pp. 1462-1468 ◽  
Author(s):  
G Liew ◽  
◽  
A Y Lee ◽  
J Zarranz-Ventura ◽  
I Stratton ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Real World ◽  
Neovascular Amd ◽  
The Uk

Treatment Patterns and Clinical Outcomes for Branch Retinal Vein Occlusion: An 8-Year Experience at a Tertiary Eye Center

2021 ◽  
pp. 247412642097887
Author(s):  
Terry Lee ◽  
Cason B. Robbins ◽  
Akshay S. Thomas ◽  
Sharon Fekrat
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Retinal Vein Occlusion ◽  
Real World ◽  
Early Treatment ◽  
Branch Retinal Vein Occlusion ◽  
Treatment Patterns ◽  
Vein Occlusion ◽  
Anti Vegf ◽  
Treatment Naïve

Purpose: This work aims to investigate real-world treatment patterns and outcomes in eyes with branch retinal vein occlusion in the antivascular endothelial growth factor (anti-VEGF) era. Methods: A retrospective, nonrandomized, comparative study was conducted on eyes diagnosed with branch retinal vein occlusion at a single tertiary center between 2009 and 2017. Medical history, treatment patterns, and visual acuity outcomes were examined. Subanalysis was performed for eyes that met the eligibility criteria for the BRAVO (Ranibizumab for the Treatment of Macular Edema Following Branch Retinal Vein Occlusion) trial. Results: A total of 315 eyes were included, of which 244 were treatment naive. In all eyes, the most common first treatment was the following: intravitreal bevacizumab (38.4%), aflibercept (15.1%), ranibizumab (8.1%), sectoral scatter laser (6.2%), and triamcinolone (3.1%). At 1 year, treatment-naive eyes had received an average of 2.43 anti-VEGF injections. During follow-up, treatment-naive eyes gained an average of 0.21 Early Treatment Diabetic Retinopathy Study lines. Forty eyes that met BRAVO trial criteria received an average of 5.05 anti-VEGF injections in the first year and gained an average of 1.83 Early Treatment Diabetic Retinopathy Study lines. Conclusions: This real-world cohort received fewer anti-VEGF injections at year 1 and experienced less improvement in visual acuity during the course of treatment than clinical trial participants. Trial-eligible patients received more injections and had greater visual gains than those who would not have been eligible for the trial.

Real study: Re-treatment evaluated on visual acuity for Lucentis ® in neovascular AMD

2018 ◽  
Vol 41 (5) ◽  
pp. 397-401
Author(s):  
D. Bellocq ◽  
F. De Bats ◽  
M. Rabilloud ◽  
L. Kodjikian
Keyword(s):  
Visual Acuity ◽  
Neovascular Amd

scholarly journals Identifying important nodes from content-associated heterogeneous graph by LeaderRank

2021 ◽  
Vol 2113 (1) ◽  
pp. 012082
Author(s):  
Yulong Dai ◽  
Qiyou Shen ◽  
Xiangqian Xu ◽  
Jun Yang
Keyword(s):  
Real World ◽  
Experimental Analysis ◽  
Differential Information ◽  
World Systems ◽  
Ranking Problem ◽  
Data Set ◽  
Importance Ranking ◽  
Basic Concepts ◽  
Important Nodes ◽  
Graph Nodes

Abstract Most real-world systems consist of a large number of interacting entities of many types. However, most of the current researches on systems are based on the assumption that the type of node or link in the network is unique. In other words, the network is homogeneous, containing the same type of nodes and links. Based on this assumption, differential information between nodes and edges is ignored. This paper firstly introduces the research background, challenges and significance of this research. Secondly, the basic concepts of the model are introduced. Thirdly, a novel type-sensitive LeaderRank algorithm is proposed and combined with distance rule to solve the importance ranking problem of content-associated heterogeneous graph nodes. Finally, the writer influence data set is used for experimental analysis to further prove the validity of the model.

scholarly journals An 11-bit High Dynamic Range (HDR) Luminance Display and Its Use to Discover Contextual Mechanisms of Real-World Luminance Normalization for Visual Acuity and Target Discrimination

2019 ◽  
Author(s):  
Chou P Hung ◽  
Chloe Callahan-Flintoft ◽  
Paul D Fedele ◽  
Kim F Fluitt ◽  
Onyekachi Odoemene ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Real World ◽  
Dynamic Range ◽  
High Dynamic Range ◽  
Automatic Target Recognition ◽  
Facilitation Effect ◽  
Software Environment ◽  
Temporal Precision ◽  
Central Target ◽  
High Dynamic

ABSTRACTLuminance can vary widely when scanning across a scene, by up to 10^9 to 1, requiring multiple normalizing mechanisms spanning from the retina to cortex to support visual acuity and recognition. Vision models based on standard dynamic range luminance contrast ratios below 100 to 1 have limited ability to generalize to real-world scenes with contrast ratios over 10,000 to 1 (high dynamic range [HDR]). Understanding and modeling brain mechanisms of HDR luminance normalization is thus important for military applications, including automatic target recognition, display tone mapping, and camouflage. Yet, computer display of HDR stimuli was until recently unavailable or impractical for research. Here we describe procedures for setup, calibration, and precision check of an HDR display system with over 100,000 to 1 luminance dynamic range (650–0.0065 cd/m^2), pseudo 11-bit grayscale precision, and 3-ms temporal precision in the MATLAB/Psychtoolbox software environment. The setup is synchronized with electroencephalography and IR eye-tracking measurements. We report measures of HDR visual acuity and the discovery of a novel phenomenon—that abrupt darkening (from 400 to 4 cd/m^2) engages contextual facilitation, distorting the perceived orientation of a high-contrast central target. Surprisingly, the facilitation effect depended on luminance similarity, contradicting both classic divisive and subtractive models of contextual normalization.

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