scholarly journals Magnetic Resonance Imaging Assessment of Regional Cerebral Blood Flow after Asphyxial Cardiac Arrest in Immature Rats

2008 ◽  
Vol 29 (1) ◽  
pp. 197-205 ◽  
Author(s):  
Mioara D Manole ◽  
Lesley M Foley ◽  
T Kevin Hitchens ◽  
Patrick M Kochanek ◽  
Robert W Hickey ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Assessment ◽  
Baseline Values ◽  
The Relationship ◽  
Asphyxial Cardiac Arrest

Cerebral blood flow (CBF) alterations after asphyxial cardiac arrest (CA) are not defined in developmental animal models or humans. We characterized regional and temporal changes in CBF from 5 to 150 mins after asphyxial CA of increasing duration (8.5, 9, 12 min) in postnatal day (PND) 17 rats using the noninvasive method of arterial spin-labeled magnetic resonance imaging (ASL-MRI). We also assessed blood-brain barrier (BBB) permeability, and evaluated the relationship between CBF and mean arterial pressure after resuscitation. After all durations of asphyxia CBF alterations were region dependent. After 8.5- and 9-min asphyxia, intense subcortical hyperemia at 5 min was followed by return of CBF to baseline values by 10 mins. After 12-min asphyxia, hyperemia was absent and hypoperfusion reached a nadir of 38% to 65% of baselines with the lowest values in the cortex. BBB was impermeable to gadoteridol 150 mins after CA. CBF in the 12-min CA group was blood pressure passive at 60 min assessed via infusion of epinephrine. ASL-MRI assessment of CBF after asphyxial Ca in PND 17 rats reveals marked duration and region-specific reperfusion patterns and identifies possible new therapeutic targets.

scholarly journals Global and Regional Derangements of Cerebral Blood Flow and Diffusion Magnetic Resonance Imaging after Pediatric Cardiac Arrest

2016 ◽  
Vol 169 ◽  
pp. 28-35.e1 ◽  
Author(s):  
Leah C. Manchester ◽  
Vince Lee ◽  
Vincent Schmithorst ◽  
Patrick M. Kochanek ◽  
Ashok Panigrahy ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Diffusion Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
And Diffusion

scholarly journals Improved brain perfusion after electrical cardioversion of atrial fibrillation

EP Europace ◽  
2019 ◽  
Vol 22 (4) ◽  
pp. 530-537 ◽  
Author(s):  
Marianna Gardarsdottir ◽  
Sigurdur Sigurdsson ◽  
Thor Aspelund ◽  
Valdis Anna Gardarsdottir ◽  
Lars Forsberg ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Atrial Fibrillation ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Brain Perfusion ◽  
Resonance Imaging ◽  
Flow Measurements ◽  
Before And After ◽  
Blood Flow Measurements

Abstract Aims Atrial fibrillation (AF) has been associated with reduced brain volume, cognitive impairment, and reduced cerebral blood flow. The causes of reduced cerebral blood flow in AF are unknown, but no reduction was seen in individuals without the arrhythmia in a previous study. The aim of this study was to test the hypothesis that brain perfusion, measured with magnetic resonance imaging (MRI), improves after cardioversion of AF to sinus rhythm (SR). Methods and results All patients undergoing elective cardioversion at our institution were invited to participate. A total of 44 individuals were included. Magnetic resonance imaging studies were done before and after cardioversion with both brain perfusion and cerebral blood flow measurements. However, 17 did not complete the second MRI as they had a recurrence of AF during the observation period (recurrent AF group), leaving 17 in the SR group and 10 in the AF group to complete both measurements. Brain perfusion increased after cardioversion to SR by 4.9 mL/100 g/min in the whole brain (P < 0.001) and by 5.6 mL/100 g/min in grey matter (P < 0.001). Cerebral blood flow increased by 58.6 mL/min (P < 0.05). Both brain perfusion and cerebral blood flow remained unchanged when cardioversion was unsuccessful. Conclusion In this study of individuals undergoing elective cardioversion for AF, restoration, and maintenance of SR for at least 10 weeks after was associated with an improvement of brain perfusion and cerebral blood flow measured by both arterial spin labelling and phase contrast MRI. In those individuals where cardioversion was unsuccessful, there was no change in perfusion or blood flow.

Sign in / Sign up

Export Citation Format

Share Document