Are genetic polymorphisms in the renin–angiotensin–aldosterone system associated with essential hypertension? Evidence from genome-wide association studies

2017 ◽  
Vol 31 (11) ◽  
pp. 695-698 ◽  
Author(s):  
L-D Ji ◽  
J-Y Li ◽  
B-B Yao ◽  
X-B Cai ◽  
Q-J Shen ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Genetic Polymorphisms ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Genome Wide

scholarly journals An Academic Clinician’s Road Map to Hypertension Genomics

Hypertension ◽  
2021 ◽  
Author(s):  
Emma F. Magavern ◽  
Helen R. Warren ◽  
Fu L. Ng ◽  
Claudia P. Cabrera ◽  
Patricia B. Munroe ◽  
...  
Keyword(s):  
Big Data ◽  
Essential Hypertension ◽  
Clinical Benefit ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Polygenic Risk ◽  
Road Map ◽  
Genome Wide ◽  
Cardiovascular Morbidity And Mortality

At the dawn of the new decade, it is judicious to reflect on the boom of knowledge about polygenic risk for essential hypertension supplied by the wealth of genome-wide association studies. Hypertension continues to account for significant cardiovascular morbidity and mortality, with increasing prevalence anticipated. Here, we overview recent advances in the use of big data to understand polygenic hypertension, as well as opportunities for future innovation to translate this windfall of knowledge into clinical benefit.

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