scholarly journals Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder

2009 ◽  
Vol 15 (8) ◽  
pp. 850-855 ◽  
Author(s):  
M H Bloch ◽  
J McGuire ◽  
A Landeros-Weisenberger ◽  
J F Leckman ◽  
C Pittenger
Author(s):  
Eunice Yuen ◽  
Michael H. Bloch

This chapter provides a summary of a landmark study on adult patients with obsessive-compulsive disorder (OCD). Discussion here is based on a meta-analysis from nine prominent clinical studies. Are there any differences in efficacy and tolerability among different doses of, selective serotonin reuptake inhibitor in the treatment of OCD? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and American Psychiatry Association (APA) guideline information, discusses implications, and concludes with a relevant clinical case.


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