scholarly journals Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression

2012 ◽  
Vol 18 (2) ◽  
pp. 166-173 ◽  
Author(s):  
D A Bangasser ◽  
B A S Reyes ◽  
D Piel ◽  
V Garachh ◽  
X-Y Zhang ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Brain Norepinephrine ◽  
Norepinephrine System ◽  
The Brain

Corticotropin-Releasing Factor and the Brain Norepinephrine System

2009 ◽  
pp. 1669-1689
Author(s):  
E.J. Van Bockstaele ◽  
R.J. Valentino
Keyword(s):  
Corticotropin Releasing Factor ◽  
Brain Norepinephrine ◽  
Norepinephrine System ◽  
The Brain

scholarly journals Sexually Dimorphic Responses of the Brain Norepinephrine System to Stress and Corticotropin-Releasing Factor

2005 ◽  
Vol 31 (3) ◽  
pp. 544-554 ◽  
Author(s):  
Andre L Curtis ◽  
Thelma Bethea ◽  
Rita J Valentino
Keyword(s):  
Corticotropin Releasing Factor ◽  
Sexually Dimorphic ◽  
Brain Norepinephrine ◽  
Norepinephrine System ◽  
The Brain

scholarly journals The brain norepinephrine system, stress and cardiovascular vulnerability

2017 ◽  
Vol 74 ◽  
pp. 393-400 ◽  
Author(s):  
Susan K. Wood ◽  
Rita J. Valentino
Keyword(s):  
Brain Norepinephrine ◽  
Norepinephrine System ◽  
The Brain

Restraint stress exacerbates carbon tetrachloride-induced liver injury in rats: A role of endogenous corticotropin-releasing factor (CRF) in the brain

2001 ◽  
Vol 120 (5) ◽  
pp. A715-A715
Author(s):  
Y NAKADE ◽  
M YONEDA ◽  
S TAKAMOTO ◽  
T ITO ◽  
S OKAMOTO ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Restraint Stress ◽  
Corticotropin Releasing Factor ◽  
The Brain

scholarly journals Comparisons of neuroinflammation, microglial activation, and degeneration of the locus coeruleus-norepinephrine system in APP/PS1 and aging mice

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Song Cao ◽  
Daniel W. Fisher ◽  
Guadalupe Rodriguez ◽  
Tian Yu ◽  
Hongxin Dong
Keyword(s):  
Spinal Cord ◽  
Locus Coeruleus ◽  
Microglial Activation ◽  
Healthy Aging ◽  
Cell Types ◽  
Norepinephrine System ◽  
Protective Processes ◽  
The Central Nervous System ◽  
Brain And Spinal Cord ◽  
The Brain

Abstract Background The role of microglia in Alzheimer’s disease (AD) pathogenesis is becoming increasingly important, as activation of these cell types likely contributes to both pathological and protective processes associated with all phases of the disease. During early AD pathogenesis, one of the first areas of degeneration is the locus coeruleus (LC), which provides broad innervation of the central nervous system and facilitates norepinephrine (NE) transmission. Though the LC-NE is likely to influence microglial dynamics, it is unclear how these systems change with AD compared to otherwise healthy aging. Methods In this study, we evaluated the dynamic changes of neuroinflammation and neurodegeneration in the LC-NE system in the brain and spinal cord of APP/PS1 mice and aged WT mice using immunofluorescence and ELISA. Results Our results demonstrated increased expression of inflammatory cytokines and microglial activation observed in the cortex, hippocampus, and spinal cord of APP/PS1 compared to WT mice. LC-NE neuron and fiber loss as well as reduced norepinephrine transporter (NET) expression was more evident in APP/PS1 mice, although NE levels were similar between 12-month-old APP/PS1 and WT mice. Notably, the degree of microglial activation, LC-NE nerve fiber loss, and NET reduction in the brain and spinal cord were more severe in 12-month-old APP/PS1 compared to 12- and 24-month-old WT mice. Conclusion These results suggest that elevated neuroinflammation and microglial activation in the brain and spinal cord of APP/PS1 mice correlate with significant degeneration of the LC-NE system.

scholarly journals The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn

Peptides ◽  
2021 ◽  
pp. 170593
Author(s):  
Luisa Demarchi ◽  
Jodi L. Pawluski ◽  
Oliver J. Bosch
Keyword(s):  
Corticotropin Releasing Factor ◽  
The Brain

scholarly journals Social instigation and repeated aggressive confrontations in male Swiss mice: analysis of plasma corticosterone, CRF and BDNF levels in limbic brain areas

2017 ◽  
Vol 39 (2) ◽  
pp. 98-105 ◽  
Author(s):  
Paula Madeira Fortes ◽  
Lucas Albrechet-Souza ◽  
Mailton Vasconcelos ◽  
Bruna Maria Ascoli ◽  
Ana Paula Menegolla ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Physiological Responses ◽  
Plasma Corticosterone ◽  
Corticotropin Releasing Factor ◽  
Brain Areas ◽  
Social Stressors ◽  
Swiss Mice ◽  
The Brain ◽  
Over Time ◽  
Resident Intruder

Abstract Introduction: Agonistic behaviors help to ensure survival, provide advantage in competition, and communicate social status. The resident-intruder paradigm, an animal model based on male intraspecific confrontations, can be an ethologically relevant tool to investigate the neurobiology of aggressive behavior. Objectives: To examine behavioral and neurobiological mechanisms of aggressive behavior in male Swiss mice exposed to repeated confrontations in the resident intruder paradigm. Methods: Behavioral analysis was performed in association with measurements of plasma corticosterone of mice repeatedly exposed to a potential rival nearby, but inaccessible (social instigation), or to 10 sessions of social instigation followed by direct aggressive encounters. Moreover, corticotropin-releasing factor (CRF) and brain-derived neurotrophic factor (BNDF) were measured in the brain of these animals. Control mice were exposed to neither social instigation nor aggressive confrontations. Results: Mice exposed to aggressive confrontations exhibited a similar pattern of species-typical aggressive and non-aggressive behaviors on the first and the last session. Moreover, in contrast to social instigation only, repeated aggressive confrontations promoted an increase in plasma corticosterone. After 10 aggressive confrontation sessions, mice presented a non-significant trend toward reducing hippocampal levels of CRF, which inversely correlated with plasma corticosterone levels. Conversely, repeated sessions of social instigation or aggressive confrontation did not alter BDNF concentrations at the prefrontal cortex and hippocampus. Conclusion: Exposure to repeated episodes of aggressive encounters did not promote habituation over time. Additionally, CRF seems to be involved in physiological responses to social stressors.

Sign in / Sign up

Export Citation Format

Share Document