scholarly journals Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis

2016 ◽  
Vol 22 (10) ◽  
pp. 1455-1463 ◽  
Author(s):  
T Wise ◽  
J Radua ◽  
E Via ◽  
N Cardoner ◽  
O Abe ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depression ◽  
Grey Matter ◽  
Meta Analysis ◽  
Grey Matter Volume ◽  
Matter Volume

scholarly journals Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis

2019 ◽  
Vol 44 (2) ◽  
pp. 89-101 ◽  
Author(s):  
Xiuli Wang ◽  
Qiang Luo ◽  
Fangfang Tian ◽  
Bochao Cheng ◽  
Lihua Qiu ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Grey Matter ◽  
Meta Analysis ◽  
Adult Patients ◽  
Grey Matter Volume ◽  
Matter Volume

scholarly journals Lifetime major depression and grey-matter volume

2019 ◽  
Vol 44 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Marie-Laure Ancelin ◽  
Isabelle Carrière ◽  
Sylvaine Artero ◽  
Jerome Maller ◽  
Chantal Meslin ◽  
...  
Keyword(s):  
Major Depression ◽  
Grey Matter ◽  
Grey Matter Volume ◽  
Matter Volume

scholarly journals Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study

2019 ◽  
Author(s):  
Sevdalina Kandilarova ◽  
Drozdstoy Stoyanov ◽  
Nickolay Sirakov ◽  
Michael Maes ◽  
Karsten Specht
Keyword(s):  
Bipolar Disorder ◽  
Major Depression ◽  
Mood Disorders ◽  
Grey Matter ◽  
Inferior Frontal Gyrus ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Grey Matter Volume ◽  
Healthy Controls ◽  
Voxel Based Morphometry

Objective: The aim of the current study was to examine whether and to what extent mood disorders, comprising major depression and bipolar disorder, are accompanied by structural changes in the brain as measured using voxel-based morphometry (VBM). Methods: We have performed a VBM study using a 3Т MRI system (GE Discovery 750w) in patients with mood disorders (n=50), namely 39 with major depression and 11 with bipolar disorder, compared to 42 age, sex and education matched healthy controls. Results: Our results show that depression was associated with significant decreases in grey matter (GM) volume restricted to regions located in medial frontal and anterior cingulate cortex on the left side and middle frontal gyrus, medial orbital gyrus, inferior frontal gyrus (triangular and orbital parts), and middle temporal gyrus (extending to the superior temporal gyrus) on the right side. When the patient group was separated into bipolar disorder and major depression the reductions remained significant only for the patients with major depressive disorder. Conclusions: Using VBM the present study was able to replicate decreases in GM volume restricted to frontal and temporal regions in patients with mood disorders mainly major depression, as compared with healthy controls. 

scholarly journals Reduced grey matter volume in frontal and temporal areas in depression: contributions from voxel-based morphometry study

2019 ◽  
Vol 31 (05) ◽  
pp. 252-257 ◽  
Author(s):  
Sevdalina Kandilarova ◽  
Drozdstoy Stoyanov ◽  
Nickolay Sirakov ◽  
Michael Maes ◽  
Karsten Specht
Keyword(s):  
Bipolar Disorder ◽  
Major Depression ◽  
Mood Disorders ◽  
Grey Matter ◽  
Inferior Frontal Gyrus ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Grey Matter Volume ◽  
Healthy Controls ◽  
Voxel Based Morphometry

AbstractObjective:The aim of the current study was to examine whether and to what extent mood disorders, comprising major depression and bipolar disorder, are accompanied by structural changes in the brain as measured using voxel-based morphometry (VBM).Methods:We performed a VBM study using a 3Т MRI system (GE Discovery 750w) in patients with mood disorders (n=50), namely, 39 with major depression and 11 with bipolar disorder compared to 42 age-, sex- and education-matched healthy controls.Results:Our results show that depression was associated with significant decreases in grey matter (GM) volume of the regions located within the medial frontal and anterior cingulate cortex on the left side and middle frontal gyrus, medial orbital gyrus, inferior frontal gyrus (triangular and orbital parts) and middle temporal gyrus (extending to the superior temporal gyrus) on the right side. When the patient group was separated into bipolar disorder and major depression, the reductions remained significant only for patients with major depressive disorder.Conclusions:Using VBM the present study was able to replicate decreases in GM volume restricted to frontal and temporal regions in patients with mood disorders, mainly major depression, compared with healthy controls.

scholarly journals Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Xiaohui Yan ◽  
Ke Jiang ◽  
Hui Li ◽  
Ziyi Wang ◽  
Kyle Perkins ◽  
...  
Keyword(s):  
Developmental Dyslexia ◽  
Grey Matter ◽  
Meta Analysis ◽  
Inferior Frontal Gyrus ◽  
Brain Activation ◽  
Superior Temporal Gyrus ◽  
Brain Regions ◽  
Middle Temporal Gyrus ◽  
Grey Matter Volume ◽  
Matter Volume

Brain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and functional abnormalities are consistent/inconsistent across languages. In the current multimodal meta-analysis, we found convergent structural and functional alterations in the left superior temporal gyrus across languages, suggesting a neural signature of DD. We found greater reduction in grey matter volume and brain activation in the left inferior frontal gyrus in morpho-syllabic languages (e.g. Chinese) than in alphabetic languages, and greater reduction in brain activation in the left middle temporal gyrus and fusiform gyrus in alphabetic languages than in morpho-syllabic languages. These language differences are explained as consequences of being DD while learning a specific language. In addition, we also found brain regions that showed increased grey matter volume and brain activation, presumably suggesting compensations and brain regions that showed inconsistent alterations in brain structure and function. Our study provides important insights about the etiology of DD from a cross-linguistic perspective with considerations of consistency/inconsistency between structural and functional alterations.

scholarly journals Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder

2009 ◽  
Vol 194 (5) ◽  
pp. 426-433 ◽  
Author(s):  
Alex Fornito ◽  
Murat Yücel ◽  
Stephen J. Wood ◽  
Andreas Bechdolf ◽  
Simon Carter ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anterior Cingulate Cortex ◽  
Grey Matter ◽  
Cingulate Cortex ◽  
First Episode Psychosis ◽  
Anterior Cingulate ◽  
First Episode ◽  
Grey Matter Volume ◽  
Matter Volume ◽  
Episode Psychosis

BackgroundThe anterior cingulate cortex is frequently implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies have reported variable findings owing to a reliance on patient samples with chronic illness and to limited appreciation of the region's heterogeneity.AimsTo characterise anterior cingulate cortex abnormalities in patients with bipolar disorder experiencing their first episode of psychosis while accounting for regional anatomical variability.MethodGrey matter volume, surface area and cortical thickness were measured in six anterior cingulate cortex subregions per hemisphere using MRI scans acquired from 26 patients with bipolar I disorder experiencing first-episode psychosis and 26 healthy controls matched for age, gender and regional morphological variability.ResultsRelative to controls, male patients displayed increased thickness in the right subcallosal limbic anterior cingulate cortex. No significant differences were identified in females for grey matter volume or surface area measures. The findings were not attributable to medication effects.ConclusionsThese data suggest that first-episode psychosis in bipolar disorder is associated with a gender-specific, right-lateralised thickness increase in anterior cingulate cortex subregions known to play a role in regulating physiological stress responses.

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