Molecular devices: A brilliant crossword puzzle

Nature China ◽  
2007 ◽  
Author(s):  
Anne Pichon
Author(s):  
О. V. Ivanova

The article discusses one of the stages of the educational process with the use of modular visualization that is systematization and synthesis of educational material. Various forms of visual repetition when studying the discipline “Theory of Probability and Mathematical Statistics” for undergraduate students who study non-mathematical profiles are presented. The concept of modular visualization is revealed, all types of each of the presented forms of visual repetition are described: through the conceptual apparatus (types: crossword puzzle, mathematical dictation, work with definitions, classification of concepts), transformation of knowledge (types: reference summary, proof of theorems, work with formulas, dictionary knowledge), by means of large-modular supports (types: table, flowchart, graph-diagram). Examples of each type of visual repetition of educational information on the discipline “Theory of Probability and Mathematical Statistics” developed by SMART Notebook and HTML are given. The technology of constructing various forms of visual repetition is presented schematically.


Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3085
Author(s):  
Louay Bettaieb ◽  
Maxime Brulé ◽  
Axel Chomy ◽  
Mel Diedro ◽  
Malory Fruit ◽  
...  

Pancreatic cancer (PC) is a major cause of cancer-associated mortality in Western countries (and estimated to be the second cause of cancer deaths by 2030). The main form of PC is pancreatic adenocarcinoma, which is the fourth most common cause of cancer-related death, and this situation has remained virtually unchanged for several decades. Pancreatic ductal adenocarcinoma (PDAC) is inherently linked to the unique physiology and microenvironment of the exocrine pancreas, such as pH, mechanical stress, and hypoxia. Of them, calcium (Ca2+) signals, being pivotal molecular devices in sensing and integrating signals from the microenvironment, are emerging to be particularly relevant in cancer. Mutations or aberrant expression of key proteins that control Ca2+ levels can cause deregulation of Ca2+-dependent effectors that control signaling pathways determining the cells’ behavior in a way that promotes pathophysiological cancer hallmarks, such as enhanced proliferation, survival and invasion. So far, it is essentially unknown how the cancer-associated Ca2+ signaling is regulated within the characteristic landscape of PDAC. This work provides a complete overview of the Ca2+ signaling and its main players in PDAC. Special consideration is given to the Ca2+ signaling as a potential target in PDAC treatment and its role in drug resistance.


Preview ◽  
2021 ◽  
Vol 2021 (211) ◽  
pp. 51-51
Keyword(s):  

2019 ◽  
Vol 1363 ◽  
pp. 012075
Author(s):  
Nurdin ◽  
Rizki Azhar ◽  
Dahlan Abdullah ◽  
Cut Ita Erliana ◽  
Odi Nurdiawan ◽  
...  

1939 ◽  
Vol 8 (24) ◽  
pp. 129-138 ◽  
Author(s):  
R. P. Austin

The casual reader, on seeing these lines, might be forgiven for the thought that Lord Byron had the crossword puzzle in mind when he wrote them. In an uncertain world nothing is more certain than that this was not the case. Byron died in 1824. The crossword puzzle was born, at least in its popular modern shape, almost precisely a century later. Its history begins suddenly. Neither in the Concise Oxford Dictionary of 1921, nor in the twelfth edition of Encyclopaedia Britannica, dated 1922, does the crossword appear at all. But from the year 1923 references to it become increasingly frequent. In 1924 a popular work entitled The Crossword Puzzle Book was published. In 1925 there was a reference to crosswords in Punch. In 1926 the thirteenth edition of Encyclopaedia Britannica had a short article on it. In 1928 the crossword puzzle was mentioned in Galsworthy's Swan Song. From that time every good standard dictionary or work of reference has included it. These facts document its emergence as a literary phenomenon in Great Britain. The history of the crossword in the United States is very similar, except that it would appear to have achieved stardom in the popular firmament a few months earlier in that country than in this.


PACEsetterS ◽  
2008 ◽  
Vol 5 (3) ◽  
pp. 30
Author(s):  
&NA;
Keyword(s):  

1978 ◽  
Vol 9 (6) ◽  
pp. 43-43
Author(s):  
Donna Buker
Keyword(s):  

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