Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA

1997 ◽  
Vol 3 (12) ◽  
pp. 1394-1397 ◽  
Author(s):  
Samantha S. Soldan ◽  
Rossana Berti ◽  
Nazi Salem ◽  
Paola Secchiero ◽  
Louis Flamand ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Herpes Virus ◽  
Human Herpes ◽  
Early Antigen ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus

Role of human herpes virus 6 in multiple sclerosis, neuro-AIDS, brain lymphoma and control brain

1994 ◽  
Vol 54 (1-2) ◽  
pp. 176
Author(s):  
W. Liedtke ◽  
R. Malessa ◽  
P.M. Faustmann ◽  
K. Schwechheimer ◽  
K. Truebner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Herpes Virus ◽  
Human Herpes ◽  
Brain Lymphoma ◽  
Control Brain ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus ◽  
And Control

Human herpes virus 6 status in relapsing-remitting multiple sclerosis patients

2017 ◽  
Vol 47 (3) ◽  
pp. 339-341 ◽  
Author(s):  
Ahmad Nejati ◽  
Zabihollah Shoja ◽  
Mohammad Farahmand ◽  
Shohreh Shahmahmoodi ◽  
Kaveh Akrami ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Relapsing Remitting ◽  
Human Herpes Virus 6 ◽  
Remitting Multiple Sclerosis ◽  
Herpès Virus ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Monitoring of Active Human Herpes Virus 6 Infection in Iranian Patients with Different Subtypes of Multiple Sclerosis

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Nourollah Ramroodi ◽  
Nima Sanadgol ◽  
Zohre Ganjali ◽  
Abbas Ali Niazi ◽  
Vida Sarabandi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Herpes Virus ◽  
Mononuclear Cells ◽  
Healthy Controls ◽  
Viral Sequence ◽  
Human Herpes ◽  
Viral Dna ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus

Background. Recently, it has been suggested that human herpes virus 6 (HHV6) may play a role in the pathogenesis of multiple sclerosis (MS). Our purpose is to determine the incidence of reactivated HHV6 in MS patients.Methods. Viral sequence analyzed by qPCR in the peripheral blood mononuclear cells (PBMCs), serum, and saliva samples of different subtypes of MS patients (n=78) and healthy controls (n=123). HHV6 IgG and IgM antibody levels measured by ELISA technique in the plasma samples of both groups. Likewise, cerebrospinal fluid (CSF) samples of some MS patients (n=38) were analyzed for viral sequence.Results. Results demonstrate increased levels of anti-HHV6-IgG (78.2% versus 76.4% in controls;P=NS), and IgM (34.6% versus 6.5% in controls;P<0.05) in MS patients. Furthermore, RRMS and SPMS patients showed relatively higher anti-HHV6 IgG and IgM compared to PPMS (P<0.001). Moreover, load of cell-free viral DNA was higher in RRMS and SPMS patients and detected in 60.2% (47/78) of MS patients, compared with 14.6% (18/123) of healthy controls (P<0.001). Moreover, load of cell-free viral DNA was higher in RRMS and SPMS patients and detected in 60.2% (47/78) of MS patients, compared with 14.6% (18/123) of healthy controls (P<0.001).Conclusions. The results extend the observation of an increased frequency of systemic reactivated HHV6 infection in MS patients with developed stages of disease.

scholarly journals Mini review article. Human herpesvirus-6 and the etiology of multiple sclerosis: a literature review

2014 ◽  
Vol 8 (3) ◽  
pp. 303-313
Author(s):  
Gloudina M. Hon ◽  
Rajiv T. Erasmus ◽  
Tandi E. Matsha
Keyword(s):  
Multiple Sclerosis ◽  
Herpes Virus ◽  
Human Herpesvirus ◽  
Background Information ◽  
Human Herpes ◽  
Case Control Studies ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus

AbstractBackground: There is no consensus in the literature on the role of human herpes virus-6 (HHV-6) in multiple sclerosis (MS) onset or progression.Objective: We evaluated a possible role for HHV-6 in MS onset and progression.Methods: We conducted a literature search of PubMed and Google scholar with the following search terms: (“multiple sclerosis” OR “MS”) and (“Human Herpes Virus-6” OR “HHV-6”).Results: A total 21 publications were retrieved, of which 19 case-control studies were included. A further 25 articles were retrieved for background information.Conclusion: There was insufficient evidence to support a role of HHV-6 in MS onset and progression.

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