scholarly journals In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide

2007 ◽  
Vol 13 (10) ◽  
pp. 1253-1258 ◽  
Author(s):  
Martina A McAteer ◽  
Nicola R Sibson ◽  
Constantin von zur Muhlen ◽  
Jurgen E Schneider ◽  
Andrew S Lowe ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Brain Inflammation ◽  
Resonance Imaging

Iron-oxide-based twin nanoplates with strong T2 relaxation shortening for contrast-enhanced magnetic resonance imaging

Nanoscale ◽  
2018 ◽  
Vol 10 (38) ◽  
pp. 18398-18406 ◽  
Author(s):  
Ruixue Wei ◽  
Tiantian Zhou ◽  
Chengjie Sun ◽  
Hongyu Lin ◽  
Lijiao Yang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Tumor Imaging ◽  
Resonance Imaging ◽  
T2 Relaxation ◽  
Contrast Enhanced

Iron oxide twin nanoplates with high T2 relaxivity for in vivo contrast-enhanced magnetic resonance imaging and tumor imaging were reported.

scholarly journals Dendrimer-Functionalized Shell-crosslinked Iron Oxide Nanoparticles for In-Vivo Magnetic Resonance Imaging of Tumors

2008 ◽  
Vol 20 (9) ◽  
pp. 1671-1678 ◽  
Author(s):  
Xiangyang Shi ◽  
Su He Wang ◽  
Scott D. Swanson ◽  
Song Ge ◽  
Zhengyi Cao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

Magnetic Resonance Imaging of Brain Inflammation Using Microparticles of Iron Oxide

2010 ◽  
pp. 103-115 ◽  
Author(s):  
Martina A. McAteer ◽  
Constantin von Zur Muhlen ◽  
Daniel C. Anthony ◽  
Nicola R. Sibson ◽  
Robin P. Choudhury
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Brain Inflammation ◽  
Resonance Imaging

Magnetic Resonance Imaging Tracking of Stem Cells in Vivo Using Iron Oxide Nanoparticles as a Tool for the Advancement of Clinical Regenerative Medicine

2011 ◽  
Vol 111 (2) ◽  
pp. 253-280 ◽  
Author(s):  
Morteza Mahmoudi ◽  
Hossein Hosseinkhani ◽  
Mohsen Hosseinkhani ◽  
Sebastien Boutry ◽  
Abdolreza Simchi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Stem Cells ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Regenerative Medicine ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

scholarly journals Magnetic Resonance Imaging of Atherosclerosis Using CD81-Targeted Microparticles of Iron Oxide in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Fei Yan ◽  
Wei Yang ◽  
Xiang Li ◽  
Hongmei Liu ◽  
Xiang Nan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Relaxation Time ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
T2 Relaxation Time ◽  
Resonance Imaging ◽  
T2 Relaxation ◽  
Atherosclerotic Lesions ◽  
Deficient Mice

The goal of this study is to investigate the feasibility of using CD81- (Cluster of Differentiation 81 protein-) targeted microparticles of iron oxide (CD81-MPIO) for magnetic resonance imaging (MRI) of the murine atherosclerosis. CD81-MPIO and IgG- (Immunoglobulin G-) MPIO were prepared by covalently conjugating, respectively, with anti-CD81 monoclonal and IgG antibodies to the surface of the tosyl activated MPIO. The relevant binding capability of the MPIO was examined by incubating them with murine bEnd.3 cells stimulated with phenazine methosulfate (PMS) and its effect in shortening T2 relaxation time was also examined. MRI in apolipoprotein E-deficient mice was studied in vivo. Our results show that CD81-MPIO, but not IgG-MPIO, can bind to the PMS-stimulated bEnd.3 cells. The T2 relaxation time was significantly shortened for stimulated bEnd.3 cells when compared with IgG-MPIO. In vivo MRI in apolipoprotein E-deficient mice showed highly conspicuous areas of low signal after CD81-MPIO injection. Quantitative analysis of the area of CD81-MPIO contrast effects showed 8.96- and 6.98-fold increase in comparison with IgG-MPIO or plain MPIO, respectively (P<0.01). Histological assay confirmed the expression of CD81 and CD81-MPIO binding onto atherosclerotic lesions. In conclusion, CD81-MPIO allows molecular assessment of murine atherosclerotic lesions by magnetic resonance imaging.

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