Mobility and cycling of synaptic protein–containing vesicles in axonal growth cone filopodia

2003 ◽  
Vol 6 (12) ◽  
pp. 1264-1269 ◽  
Author(s):  
Shasta L Sabo ◽  
A Kimberley McAllister
Keyword(s):  
Growth Cone ◽  
Axonal Growth ◽  
Synaptic Protein ◽  
Axonal Growth Cone

Comparative Analysis of Neural Crest Cell and Axonal Growth Cone Dynamics and Behavior

2007 ◽  
pp. 282-301
Author(s):  
Frances Lefcort ◽  
Tim O'Connor ◽  
Paul M. Kulesa
Keyword(s):  
Comparative Analysis ◽  
Neural Crest ◽  
Growth Cone ◽  
Neural Crest Cell ◽  
Axonal Growth ◽  
Axonal Growth Cone ◽  
And Behavior ◽  
Crest Cell

scholarly journals Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration

2020 ◽  
Vol 14 ◽  
Author(s):  
Michael J. Rigby ◽  
Timothy M. Gomez ◽  
Luigi Puglielli
Keyword(s):  
Glial Cell ◽  
Growth Cone ◽  
Axonal Growth ◽  
Axonal Growth Cone

scholarly journals Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization

2016 ◽  
Vol 137 (5) ◽  
pp. 744-755 ◽  
Author(s):  
Lucas J. Sosa ◽  
James S. Malter ◽  
Jie Hu ◽  
Florentyna Bustos Plonka ◽  
Mariana Oksdath ◽  
...  
Keyword(s):  
Growth Cone ◽  
Axonal Growth ◽  
Kinase Substrate ◽  
Axonal Growth Cone

scholarly journals Plexin-B1/RhoGEF–mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

2004 ◽  
Vol 165 (6) ◽  
pp. 869-880 ◽  
Author(s):  
Jakub M. Swiercz ◽  
Rohini Kuner ◽  
Stefan Offermanns
Keyword(s):  
Tyrosine Kinase ◽  
Growth Cone ◽  
Receptor Tyrosine Kinase ◽  
Hippocampal Neurons ◽  
Molecular Mechanisms ◽  
Axonal Growth ◽  
Dominant Negative ◽  
Growth Cone Collapse ◽  
Rhoa Activation ◽  
Axonal Growth Cone

Plexins are widely expressed transmembrane proteins that mediate the effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still rather unclear. Plexin-B1 has recently been shown to mediate activation of RhoA through a stable interaction with the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG. However, it is unclear how the activity of plexin-B1 and its downstream effectors is regulated by its ligand Sema4D. Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. A dominant-negative form of ErbB-2 blocks Sema4D-induced RhoA activation as well as axonal growth cone collapse in primary hippocampal neurons. Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2–mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse.

Transduction of Inhibitory Signals by the Axonal Growth Cone

2000 ◽  
pp. 131-153
Author(s):  
Li-Hsien Wang ◽  
Alyson Fournier ◽  
Fumio Nakamura ◽  
Takuya Takahashi ◽  
Robert G. Kalb ◽  
...  
Keyword(s):  
Growth Cone ◽  
Axonal Growth ◽  
Axonal Growth Cone

scholarly journals Functional Complexity of the Axonal Growth Cone: A Proteomic Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31858 ◽  
Author(s):  
Adriana Estrada-Bernal ◽  
Staci D. Sanford ◽  
Lucas J. Sosa ◽  
Glenn C. Simon ◽  
Kirk C. Hansen ◽  
...  
Keyword(s):  
Growth Cone ◽  
Proteomic Analysis ◽  
Axonal Growth ◽  
Axonal Growth Cone ◽  
Functional Complexity
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