scholarly journals Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization

2016 ◽  
Vol 137 (5) ◽  
pp. 744-755 ◽  
Author(s):  
Lucas J. Sosa ◽  
James S. Malter ◽  
Jie Hu ◽  
Florentyna Bustos Plonka ◽  
Mariana Oksdath ◽  
...  
Keyword(s):  
Growth Cone ◽  
Axonal Growth ◽  
Kinase Substrate ◽  
Axonal Growth Cone

Comparative Analysis of Neural Crest Cell and Axonal Growth Cone Dynamics and Behavior

2007 ◽  
pp. 282-301
Author(s):  
Frances Lefcort ◽  
Tim O'Connor ◽  
Paul M. Kulesa
Keyword(s):  
Comparative Analysis ◽  
Neural Crest ◽  
Growth Cone ◽  
Neural Crest Cell ◽  
Axonal Growth ◽  
Axonal Growth Cone ◽  
And Behavior ◽  
Crest Cell

scholarly journals Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration

2020 ◽  
Vol 14 ◽  
Author(s):  
Michael J. Rigby ◽  
Timothy M. Gomez ◽  
Luigi Puglielli
Keyword(s):  
Glial Cell ◽  
Growth Cone ◽  
Axonal Growth ◽  
Axonal Growth Cone

scholarly journals Plexin-B1/RhoGEF–mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

2004 ◽  
Vol 165 (6) ◽  
pp. 869-880 ◽  
Author(s):  
Jakub M. Swiercz ◽  
Rohini Kuner ◽  
Stefan Offermanns
Keyword(s):  
Tyrosine Kinase ◽  
Growth Cone ◽  
Receptor Tyrosine Kinase ◽  
Hippocampal Neurons ◽  
Molecular Mechanisms ◽  
Axonal Growth ◽  
Dominant Negative ◽  
Growth Cone Collapse ◽  
Rhoa Activation ◽  
Axonal Growth Cone

Plexins are widely expressed transmembrane proteins that mediate the effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still rather unclear. Plexin-B1 has recently been shown to mediate activation of RhoA through a stable interaction with the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG. However, it is unclear how the activity of plexin-B1 and its downstream effectors is regulated by its ligand Sema4D. Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. A dominant-negative form of ErbB-2 blocks Sema4D-induced RhoA activation as well as axonal growth cone collapse in primary hippocampal neurons. Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2–mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse.

Transduction of Inhibitory Signals by the Axonal Growth Cone

2000 ◽  
pp. 131-153
Author(s):  
Li-Hsien Wang ◽  
Alyson Fournier ◽  
Fumio Nakamura ◽  
Takuya Takahashi ◽  
Robert G. Kalb ◽  
...  
Keyword(s):  
Growth Cone ◽  
Axonal Growth ◽  
Axonal Growth Cone

scholarly journals Functional Complexity of the Axonal Growth Cone: A Proteomic Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31858 ◽  
Author(s):  
Adriana Estrada-Bernal ◽  
Staci D. Sanford ◽  
Lucas J. Sosa ◽  
Glenn C. Simon ◽  
Kirk C. Hansen ◽  
...  
Keyword(s):  
Growth Cone ◽  
Proteomic Analysis ◽  
Axonal Growth ◽  
Axonal Growth Cone ◽  
Functional Complexity

Mobility and cycling of synaptic protein–containing vesicles in axonal growth cone filopodia

2003 ◽  
Vol 6 (12) ◽  
pp. 1264-1269 ◽  
Author(s):  
Shasta L Sabo ◽  
A Kimberley McAllister
Keyword(s):  
Growth Cone ◽  
Axonal Growth ◽  
Synaptic Protein ◽  
Axonal Growth Cone

scholarly journals Cell Adhesion-Dependent Biphasic Axon Outgrowth Elucidated by Femtosecond Laser Impulse

2021 ◽  
Author(s):  
Sohei Yamada ◽  
Kentaro Baba ◽  
Naoyuki Inagaki ◽  
Hosokawa Yoichiroh
Keyword(s):  
Cell Adhesion ◽  
Femtosecond Laser ◽  
Adhesion Strength ◽  
Growth Cone ◽  
Traction Force ◽  
Axonal Growth ◽  
Flow Speed ◽  
Axon Outgrowth ◽  
Axonal Growth Cone ◽  
Laminin Binding

Axon outgrowth is promoted by the mechanical coupling between the dynamic actin cytoskeleton and adhesive substrates via clutch and adhesion molecules in the axonal growth cone. In this study, we utilized a femtosecond laser-induced impulse to break the coupling between an axonal growth cone and an adhesive substrate, enabling us to evaluate the strength of the binding between proteins in the growth cone and a laminin substrate, and also determine the contribution of adhesion strength to axon outgrowth. We found that the adhesion strength of axonal L1 cell adhesion molecule (L1CAM)-laminin binding increased with the density of the laminin substrate. In addition, fluorescent speckle microscopy revealed that the retrograde flow of actin filaments in the axonal growth cone was dependent on the laminin density such that the flow speed reduced with increasing L1CAM-laminin binding. However, axon outgrowth did not increase monotonically with increased L1CAM-laminin binding but rather exhibited biphasic behavior, in which the outgrowth was suppressed by excessive L1CAM-laminin binding. Our quantitative evaluations of the adhesion strength suggest that the biphasic outgrowth is regulated by the balance between traction force and adhesion strength as a result of changes in the number of L1CAM-laminin interactions. These results imply that adhesion modulation is key to the regulation of axon guidance.

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