scholarly journals The NCI-Nature Pathway Interaction Database: A cell signaling resource.

2007 ◽  
Author(s):  
Shiva Krupa ◽  
Kira Anthony ◽  
Jeffrey Buchoff ◽  
Matthew Day ◽  
Timo Hannay ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Interaction Database ◽  
Pathway Interaction ◽  
Pathway Interaction Database ◽  
A Cell

Abstract LB-130: The NCI-Nature Pathway Interaction Database: A cell signaling resource

2010 ◽  
Author(s):  
Carl F. Schaefer ◽  
Kira Anthony ◽  
Mhairi A. Skinner ◽  
Jeffrey R. Buchoff ◽  
Matthew Day ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Interaction Database ◽  
Pathway Interaction ◽  
Pathway Interaction Database ◽  
A Cell

Abstract 2885: The NCI-Nature Pathway Interaction Database: A comprehensive resource for cell signaling information

2011 ◽  
Author(s):  
Kira Anthony ◽  
Mhairi A. Skinner ◽  
Jeffrey R. Buchoff ◽  
Nicola McCarthy ◽  
Carl F. Schaefer ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Interaction Database ◽  
Pathway Interaction ◽  
Pathway Interaction Database

scholarly journals PID: the Pathway Interaction Database

2008 ◽  
Vol 37 (suppl_1) ◽  
pp. D674-D679 ◽  
Author(s):  
Carl F. Schaefer ◽  
Kira Anthony ◽  
Shiva Krupa ◽  
Jeffrey Buchoff ◽  
Matthew Day ◽  
...  
Keyword(s):  
Interaction Database ◽  
Pathway Interaction ◽  
Pathway Interaction Database

scholarly journals PID: The Pathway Interaction Database

2008 ◽  
Author(s):  
Carl Schaefer ◽  
Kira Anthony ◽  
Shiva Krupa ◽  
Jeffrey Buchoff ◽  
Matthew Day ◽  
...  
Keyword(s):  
Interaction Database ◽  
Pathway Interaction ◽  
Pathway Interaction Database

Protein Flexibility Catalyzes a Cell Signaling Reaction of the Ras-GAP Complex

2019 ◽  
Author(s):  
Keiei Kumon ◽  
Masahiro Higashi ◽  
Shinji Saito ◽  
Shigehiko Hayashi
Keyword(s):  
Cell Signaling ◽  
Conformational Changes ◽  
Catalytic Reaction ◽  
Protein Complex ◽  
Enzyme Mechanism ◽  
Activation Free Energy ◽  
Chemical Catalysis ◽  
Simple Chemical ◽  
A Cell ◽  
Enzyme Molecules

Many enzyme molecules exhibit characteristic global and slow dynamics which furnish them with allostery realizing remarkable molecular functionalities more than simple chemical catalysis. However, molecular mechanism of a catalytic reaction associated with the molecular flexibility of enzymes is not well-understood. Here we report a hybrid molecular simulation study on GTPase activity of a Ras-GAP protein complex for cell signaling termination. We unveiled that extensive conformational changes of the protein complex and exclusion of internal water molecules are induced upon the transition state (TS) formation in the catalytic reaction and significantly lower the reaction activation free energy. We also revealed that tumor-related mutations perturb those conformational changes upon the TS formation, leading to reduction of the catalytic activity. The findings of the remarkably dynamic protein conformation directly linking to the catalytic reaction have broad implications for understanding of enzyme mechanism and for developments of allosteric drugs and novel catalysts.

C-factor: A cell-cell signaling protein required for fruiting body morphogenesis of M. Xanthus

Cell ◽  
1990 ◽  
Vol 61 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Seung K. Kim ◽  
Dale Kaiser
Keyword(s):  
Cell Signaling ◽  
Fruiting Body ◽  
Signaling Protein ◽  
A Cell ◽  
Cell Cell

scholarly journals Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2264
Author(s):  
Jolanda. J.D. de Roo ◽  
Frank. J.T. Staal
Keyword(s):  
Stem Cells ◽  
Cell Signaling ◽  
Hematopoietic Stem Cells ◽  
Hedgehog Signaling ◽  
Hematopoietic Stem ◽  
Signaling Dynamics ◽  
Pathway Interaction ◽  
Complex Signaling ◽  
Genetic Constructs ◽  
Cell Signaling Pathways

Hematopoietic stem cells (HSCs) develop at several anatomical locations and are thought to undergo different niche regulatory cues originating from highly conserved cell signaling pathways, such as Wnt, Notch, TGF-β family, and Hedgehog signaling. Most insight into these pathways has been obtained by reporter models and loss- or gain of function experiments, yet results differ in many cases according to the approach. In this review, we discuss existing murine reporter models regarding these pathways, considering the genetic constructs and reporter proteins in the context of HSC studies; yet these models are relevant for all other stem cell systems. Lastly, we describe a multi-reporter model to properly study and understand the cross-pathway interaction and how reporter models are highly valuable tools to understand complex signaling dynamics in stem cells.

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