The Drosophila nephrocyte has a glomerular filtration system

2014 ◽  
Author(s):  
Fujian Zhang ◽  
Xiangmei Chen
Keyword(s):  
Glomerular Filtration ◽  
Filtration System

Renal aluminium handling in the rat: a micropuncture assessment

2004 ◽  
Vol 107 (2) ◽  
pp. 159-165 ◽  
Author(s):  
David G. SHIRLEY ◽  
Mary F. WALTER ◽  
Stephen J. WALTER ◽  
Andrew THEWLES ◽  
Christopher J. LOTE
Keyword(s):  
Glomerular Filtration ◽  
Distal Tubule ◽  
High Dose ◽  
Aluminium Content ◽  
Filtration System ◽  
Significant Difference ◽  
Glomerular Filtrate ◽  
Aluminium Citrate ◽  
Distal Site

Uncertainties exist over the glomerular filtration of aluminium and virtually nothing is known about its segmental handling along the nephron. The present study has used micropuncture, combined with electrothermal atomic absorption spectroscopy, to determine directly the aluminium content of glomerular filtrate and of late PCTs (proximal convoluted tubules) and early distal tubules in anaesthetized Munich–Wistar rats infused with three different doses of aluminium citrate (plasma aluminium concentrations, 2.9±0.1, 5.2±0.4 and 10.0±0.9 μg·ml−1 respectively). Aluminium filtration into Bowman's space was found to be considerably greater than that predicted by an in vitro filtration system: in all three groups it was essentially filtered freely. No significant aluminium reabsorption took place along the PCT, but with every dose the FDAl (fractional delivery of aluminium; tubular fluid:plasma aluminium/inulin concentration ratio) was lower at the early distal site than at the late PCT (P<0.001 in each case), indicating net aluminium reabsorption in the loop of Henle. This reabsorption amounted to 19–26% of the filtered aluminium load. In the low- and medium-dose groups, there was no significant difference between FDAl at the early distal site and that in the final urine; however, in the high-dose group, FDAl in the urine (1.02±0.06) exceeded that at the early distal tubule (0.75±0.04; P<0.001), suggesting aluminium secretion in the distal nephron. The results indicate that aluminium loads, when complexed with citrate, are excreted efficiently owing to a combination of glomerular filtration and minimal reabsorption.

scholarly journals The Drosophila nephrocyte has a glomerular filtration system

2014 ◽  
Vol 10 (9) ◽  
pp. 491-491 ◽  
Author(s):  
Fujian Zhang ◽  
Xiangmei Chen
Keyword(s):  
Glomerular Filtration ◽  
Filtration System

Kinetics of Various 99mTc-Sn-Pyrophosphate Compounds in the Rat

1977 ◽  
Vol 16 (03) ◽  
pp. 100-103 ◽  
Author(s):  
C. Schümichen ◽  
J. Waiden ◽  
G. Hoffmann
Keyword(s):  
Glomerular Filtration ◽  
Renal Clearance ◽  
Plasma Protein ◽  
Kinetic Data ◽  
Adult Rats ◽  
Compound A ◽  
Extravascular Space ◽  
Tubular Cells ◽  
Glomerular Filtrate ◽  
Kinetics Of

SummaryThe kinetic data of two different 99mTc-Sn-pyrophosphate compounds (compound A and B) were evaluated in non-adult rats. Only compound A concentrated in bone. Both compounds dispersed rapidly in the intravascular as well as the extravascular space. The plasma protein bond of both compounds increased with time after injection and impaired both the renal clearance of both compounds and the bone clearance of compound A. The renal clearance of both compounds was somewhat above that of 5 1Cr-EDTA. It is concluded that compound A and B is mainly excreted by glomerular filtration. About one fourth of the glomerular filtrate of compound B is reabsorbed and accumulated by the tubular cells.

Clinical Renal Function Testing by External Double Isotope Monitoring Technique

1971 ◽  
Vol 10 (01) ◽  
pp. 16-24
Author(s):  
J. Fog Pedersen ◽  
M. Fog Pedersen ◽  
Paul Madsen
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Correlation Coefficients ◽  
Feedback System ◽  
Effective Renal Plasma Flow ◽  
Advantages And Disadvantages

SummaryAn accurate catheter-free technique for clinical determination simultaneouslyof glomerular filtration rate and effective renal plasma flow by means of radioisotopes has been developed. The renal function is estimated by the amount of radioisotopes necessary to maintain a constant concentration in the patient’s blood. The infusion pumps are steered by a feedback system, the pumps being automatically turned on when the radiation measured over the patient’s head falls below a certain preset level and turned off when this level is again readied. 131I-iodopyracet was used for the estimation of effective renal plasma flow and125I-iothalamate estimation of the glomerular filtration rate. These clearances were compared to the conventional bladder clearances and good correlation was found between these two clearance methods (correlation coefficients 0.97 and.90 respectively). The advantages and disadvantages of this new clearance technique are discussed.

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