scholarly journals Relationship between acute kidney injury and brain MRI findings in asphyxiated newborns after therapeutic hypothermia

2013 ◽  
Vol 75 (3) ◽  
pp. 431-435 ◽  
Author(s):  
Subrata Sarkar ◽  
David J. Askenazi ◽  
Brian K. Jordan ◽  
Indira Bhagat ◽  
J.R. Bapuraj ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Therapeutic Hypothermia ◽  
Brain Mri ◽  
Kidney Injury ◽  
Mri Findings

scholarly journals Acute Kidney Injury, Recurrent Seizures, and Thrombocytopenia in a Young Patient with Lupus Nephritis: A Diagnostic Dilemma

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Hector Alvarado Verduzco ◽  
Anjali Acharya
Keyword(s):  
Blood Pressure ◽  
Acute Kidney Injury ◽  
Lupus Nephritis ◽  
Kidney Biopsy ◽  
Brain Mri ◽  
Kidney Injury ◽  
Uncontrolled Hypertension ◽  
Cerebral White Matter ◽  
Mri Findings ◽  
Class Iv

Introduction. Posterior reversible encephalopathy syndrome (PRES) is a constellation of clinical and radiologic findings. Fluctuations in blood pressure, seizures, and reversible brain MRI findings mainly in posterior cerebral white matter are the main manifestations. PRES has been associated with multiple conditions such as autoimmune disorders, pregnancy, organ transplant, and thrombotic microangiopathy (TMA). Case Presentation. A 22-year-old woman with history of Systemic Lupus Erythematous complicated with chronic kidney disease secondary to lupus nephritis class IV presented with recurrent seizures and uncontrolled hypertension. She was found to have acute kidney injury and thrombocytopenia. Repeat kidney biopsy showed diffuse endocapillary and extracapillary proliferative and membranous lupus nephritis (ISN-RPS class IV-G+V) and endothelial swelling secondary to severe hypertension but no evidence of TMA. Brain MRI showed reversible left frontal and parietal lesions that resolved after controlling the blood pressure, making PRES the diagnosis. Conclusion. PRES is an important entity that must be recognized and treated early due to the potential reversibility in the early stages. Physicians must have high suspicion for these unusual presentations. We present a case where performing kidney biopsy clinched the diagnosis in our patient with multiple confounding factors.

scholarly journals Therapeutic hypothermia and prevention of acute kidney injury: A meta-analysis of randomized controlled trials

Resuscitation ◽  
2012 ◽  
Vol 83 (2) ◽  
pp. 159-167 ◽  
Author(s):  
Paweena Susantitaphong ◽  
Mansour Alfayez ◽  
Abraham Cohen-Bucay ◽  
Ethan M. Balk ◽  
Bertrand L. Jaber
Keyword(s):  
Acute Kidney Injury ◽  
Randomized Controlled Trials ◽  
Therapeutic Hypothermia ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Controlled Trials ◽  
Randomized Controlled

P1708Therapeutic hypothermia in cardiac arrest survivors with pre-existing heart failure is nephroprotective

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Dutta ◽  
K Hari ◽  
W Qureshi
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Acute Kidney Injury ◽  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Kidney Injury ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
The Impact

Abstract Introduction The impact of therapeutic hypothermia on kidneys in cardiac arrest survivors with known congestive heart failure (CHF) is not known. Weak evidence suggests higher risk of acute kidney injury with hypothermia. Purpose The effect of hypothermia on organ function in cardiac arrest patients with preexisting CHF Methods This analysis includes 1417 comatose cardiac arrest survivors that achieved achieved return of spontaneous circulation on hospitalization and had a previous left ventricular ejection fraction (LVEF) assessment within last 1 year. Detailed chart review of these patients was performed. CHF was defined as either prior episode of congestive heart failure or presence of LVEF <50%. Odds ratio (OR) and 95% confidence intervals (CI) for association of hypothermia and acute kidney injury as well as hemodialysis at discharge among patients with and without CHF were computed using multivariable adjusted logistic regression. Results Overall, 1417 cardiac arrest patients (mean age 62.5±14.6 years, 60.2% males, 67.2% white and 29.7% black) were included in this analysis, out of which 467 (33.0%) were treated with therapeutic hypothermia and known CHF was present in 624 (44%). AKI developed in 25.2% of CHF patients that were not treated with hypothermia while, only in 18.0% among CHF patients treated with hypothermia (OR 0.56; 95% CI 0.32–0.96, p=0.03). There was an decrease in trend of requiring hemodialysis at discharge among CHF patients treated with hypothermia compared with CHF patients that were not treated with hypothermia (8.1% vs. 19.62%, p=0.019) among CHF patients not treated with hypothermia. However, there was no significant result. Conclusions Hypothermia is associated with nephroprotective effects among patients with cardiac survivors with pre-existing CHF. Future research is needed to identify subgroups that derive benefit from therapeutic hypothermia after cardiac arrest.

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