Combination of chemotherapy with BRAF inhibitors results in effective eradication of malignant melanoma by preventing ATM-dependent DNA repair

Oncogene ◽  
2021 ◽  
Author(s):  
Josune Alonso-Marañón ◽  
Alberto Villanueva ◽  
Josep Maria Piulats ◽  
María Martínez-Iniesta ◽  
Laura Solé ◽  
...  
Keyword(s):  
Dna Repair ◽  
Malignant Melanoma ◽  
Braf Inhibitors

Genetic polymorphisms in DNA repair and oxidative stress pathways associated with malignant melanoma susceptibility

2011 ◽  
Vol 47 (17) ◽  
pp. 2618-2625 ◽  
Author(s):  
Maider Ibarrola-Villava ◽  
Maria Peña-Chilet ◽  
Lara P. Fernandez ◽  
Jose A. Aviles ◽  
Matias Mayor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Repair ◽  
Malignant Melanoma ◽  
Genetic Polymorphisms ◽  
And Oxidative Stress

9308 POSTER The XPC A2920C, the XPF T30028C and the P53 Arg72Pro Polymorphisms, Involved in DNA Repair, Alter the Risk for the Malignant Melanoma

2011 ◽  
Vol 47 ◽  
pp. S654-S655 ◽  
Author(s):  
C. Oliveira ◽  
G.J. Lourenco ◽  
J.A. Rinck-Júnior ◽  
A.M. Moraes ◽  
C.S.R. Lima
Keyword(s):  
Dna Repair ◽  
Malignant Melanoma

scholarly journals New Trends in Cutaneous Melanoma Surgery

2019 ◽  
Vol 7 (18) ◽  
pp. 3090-3092
Author(s):  
Jacopo Scala ◽  
Aleksandra Vojvodic ◽  
Petar Vojvodic ◽  
Tatjana Vlaskovic-Jovicevic ◽  
Zorica Peric-Hajzler ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Sentinel Node ◽  
Surgical Management ◽  
Cutaneous Melanoma ◽  
Surgical Excision ◽  
Primary Lesion ◽  
Braf Inhibitors ◽  
Advanced Stages ◽  
Systemic Therapies

The main surgical treatment for melanoma consists in wide surgical excision of the primary lesion and the sentinel node but in recent times management of melanoma is rapidly evolving with the introduction of new systemic therapies, like BRAF inhibitors, MEK inhibitors and antibodies anti-PD-1 that show good results in controlling even advanced stages of the disease. This review aims to present data for the optimal surgical management of patients with malignant melanoma.

scholarly journals Xeroderma Pigmentosum

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Muhammad Ahmad Ghazi ◽  
Amna Maqsood ◽  
Yasir Akram ◽  
Muhammad Arshad Cheema
Keyword(s):  
Dna Repair ◽  
Malignant Melanoma ◽  
Xeroderma Pigmentosum ◽  
Clinical Characteristics ◽  
Autosomal Recessive ◽  
Early Stage ◽  
Heterogeneous Group ◽  
Hereditary Diseases ◽  
Repair Mechanism

Xeroderma pigmentosum comprises of a heterogeneous group of autosomal recessive hereditary diseases, which are characterized by a number of clinical characteristics and abnormal DNA repair mechanism. These patients are prone to multiple cutaneous malignancies at an early stage in life. We present 2 cases of xeoderma pigmentosum with malignant melanoma and conclude that such cases must be identified at an early stage and properly educated to protect themselves from malignancies.

The increased incidence of malignant melanoma in obese individuals is due to impaired melanogenesis and melanocyte DNA repair

2012 ◽  
Vol 78 (4) ◽  
pp. 533-535 ◽  
Author(s):  
Giorgio Morpurgo ◽  
Bernard Fioretti ◽  
Luigi Catacuzzeno
Keyword(s):  
Dna Repair ◽  
Malignant Melanoma
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