Inclusive Assessment Methods for a Heterogeneous Group

Contextualizing course materials is a fundamental step in integrating inclusive and appropriate methods of assessment into a post-secondary introductory-level Spanish as a Heritage Language course. The author discusses why a portfolio project is an appropriate assessment choice in the heritage language classroom. While the focus of the chapter is the implementation of contextualized input through a portfolio project, other methods of assessments, along with changes to syllabi, are discussed. The chapter outlines a contextualized assessment implementation in the form of a portfolio project in a post-secondary heritage language course.

Governing Thirdness

Khawaja Sira of Pakistan are a heterogeneous group of marginalized gender nonconforming individuals who defy traditional notions of gender and sexuality. Based on ethnographic fieldwork in Lahore, Pakistan, Governing Thirdness provides important insights about the identity, marginalization and governance of the Khawaja Sira as they try to live an unliveable life. Taking a broad view of governance, this book includes a comprehensive analysis of governance of the Khawaja Sira across legal, social and administrative institutions. It also argues that labels like third gender and transgender fails to account for the gender fluid lives and multiple types of individuals who identify as Khawaja Sira, yet these categories, largely imported from the west, are used without much thought to govern this heterogeneous group.

Republican Constellations A Reflection by José Bergamín

This note reflects on the need to reevaluate labels that protagonists of Spanish republican cultural life gave to themselves. Reasons provided by Bergamín, one of its protagonists, dismantle the importance of a famous act in Seville that canonised only a part of the actors of that cultural moment. Furthermore it allows us to understand that using those labels expand the composition of an heterogeneous group who worked together in a new political project to modernise the country. The time has come to become aware that the nomenclature still used is the product of literary historiography, strongly politicised by a dictatorial state.

MPC-1 DNA methylome analysis suggested the presence of “true” IDH-wildtype lower-grade gliomas

Background: There will be significant changes in the diagnosis of IDH-wildtype adult-type gliomas in the upcoming 5th edition of the WHO Classification of Central Nervous System Tumours. IDH-wildtype lower grade gliomas (IDHwt LGGs) that harbor molecular features of glioblastoma (EGFR amplification, the combination of whole chromosome 7 gain and whole chromosome 10 loss (7+/10-), or TERT promoter mutations) will be diagnosed as glioblastomas (GBMs), while IDH-wildtype astrocytomas will not be included as a separate tumor type. However, IDHwt LGGs are a very heterogeneous group of tumors, and further investigation is warranted particularly in those without molecular features of glioblastoma. To elucidate the biology of IDHwt LGGs, we analyzed DNA methylation profile and survival time. Materials and Methods: Of the 724 adult-type diffuse glioma samples from a multi-institutional study, 64 IDHwt LGG, including 54 without any of molecular features of GBM and 10 with PDGFRA amplification or TERT promoter mutation, were examined using Infinium MethylationEPIC BeadChip. The raw data files (IDAT files) were analyzed by the web-based DNA methylation classifier provided by DKFZ (MolecularNeuropathology.org) or by R (Version 4.0.4) using the minfi (1.34.0) and Rtsne (0.15) packages. [Result] Twenty-three out of 54 IDHwt LGGs matched known methylation classes using the DKFZ methylation classifier. In t-Distributed Stochastic Neighbor Embedding clustering analysis, 20 cases formed a cluster within the methylation class family glioblastoma, IDH-wildtype, mainly subclass RTK I (“GBM” cluster). Another 29 IDHwt LGGs formed an independent cluster (“LGG” cluster) separate from any of the existing reference groups near but not overlapping with several subtypes of pediatric-type lower grade gliomas. The “LGG” cluster cases had significantly longer overall survival than the “GBM” cluster cases. Discussion: Methylation profiling showed that IDHwt LGGs without molecular features of GBM were heterogeneous group of tumors. Our data suggested the presence of “true” IDHwt LGGs with intermediate prognosis.

Dual HER2 Blockade: An Emerging Option in Metastatic Biliary Tract Cancer?

Biliary tract cancer (BTC) includes a heterogeneous group of aggressive and rare hepatobiliary malignancies, including gallbladder cancer, ampullary carcinomas, intrahepatic cholangiocarcinoma (iCCA), and extrahepatic cholangiocarcinoma, further subclassified into distal (dCCA) and perihilar cholangiocarcinoma (pCCA) [...]

Facing the Ties That Bind: Understanding Experiences of Men With An Incarcerated Romantic Partner

This study examines what it means to be a man with an incarcerated romantic partner. Despite recognition that those experiencing familial incarceration are a heterogeneous group, the extant literature lacks a clear focus of the experience of men with incarcerated romantic partners. Using a phenomenological design, the researchers interviewed seven men with incarcerated romantic partners to explicate the essential structures of their lived experience. The interviews are explicated into six essences illuminating the experience of being a man with an incarcerated partner. Identified essences explored are: embodying the social tie facilitator, love and commitment living in future time, the sense of something missing, felt confinement, and the new normal. Fifteen additional sub-themes are discussed. These findings inform implications for both future research and policies that can aid in maintaining the ties that bind during familial incarceration.

Cognitive and Behavioral Patterns across Psychiatric Conditions

Psychiatric conditions represent a highly heterogeneous group of disorders associated with chronic distress and a sharp decline in quality of life [...]

Idiopathic pigmented gingival fibromatosis: A case report

Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as slowly progressive, local or diffuse enlargements within marginal and attached gingiva or interdental papilla. Gingival fibromatosis is a condition that can occur as an isolated disease or as a part of a syndrome or chromosomal abnormality. Here, we present the case of a 28-year-old male with pigmented gum enlargement in the maxilla and mandible. The clinical, radiographic, and histopathological features have been described in detail.

Photodermatoses in Childhood

Photodermatoses is a heterogeneous group of diseases resulting from abnormal skin hypersensitivity to sunlight and presented as local or generalized rashes. Specific sensitivity of children's skin to ultraviolet is often the first sign or clinical symptom of photodermatosis. Abnormal photosensitivity can be represented by diverse group of primary idiopathic conditions or photo-mediated aggravation of existing dermatosis. Number of genetic genodermatoses, metabolic disorders and connective tissue diseases is also widely known. These conditions can manifest with photosensitivity associated to other extracutaneous clinical and laboratory features. Timely diagnosis of photosensitivity in childhood allows to minimize long-term complications associated with insufficient photoprotection.