scholarly journals Gut microbiota dysbiosis-induced activation of the intrarenal renin–angiotensin system is involved in kidney injuries in rat diabetic nephropathy

2020 ◽  
Vol 41 (8) ◽  
pp. 1111-1118 ◽  
Author(s):  
Chen-chen Lu ◽  
Ze-bo Hu ◽  
Ru Wang ◽  
Ze-hui Hong ◽  
Jian Lu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Gut Microbiota ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Gut Microbiota Dysbiosis

scholarly journals Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels

2021 ◽  
Author(s):  
Kinga Jaworska ◽  
Mateusz Koper ◽  
Marcin Ufnal
Keyword(s):  
Gut Microbiota ◽  
Renin Angiotensin System ◽  
Gastrointestinal Diseases ◽  
Electrolyte Balance ◽  
Ample Evidence ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
System A ◽  
Potential Mediator ◽  
The One

Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI RAS), emerges as a potential mediator of microbiota-related effects. The RAS is involved in cardiovascular system homeostasis, water-electrolyte balance, intestinal absorption, glycemic control, inflammation, carcinogenesis and aging-related processes. Ample evidence suggests a bidirectional interaction between the microbiome and RAS. On the one hand, gut bacteria and their metabolites may modulate GI and systemic RAS. On the other hand, changes in the intestinal habitat caused by alterations in RAS may shape microbiota metabolic activity and composition. Notably, the pharmacodynamic effects of the RAS-targeted therapies may be in part mediated by the intestinal RAS and changes in the microbiome. This review summarizes studies on gut microbiota and RAS physiology. Expanding the research on this topic may lay a foundation for new therapeutic paradigms in gastrointestinal diseases and multiple systemic disorders.

scholarly journals SP300CIRCULATING TNF RECEPTOR LEVELS AND RENAL DISEASE PROGRESSION IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY AND BLOCKADE OF THE RENIN ANGIOTENSIN SYSTEM

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii478-iii479
Author(s):  
Gema Maria Fernandez Juarez ◽  
Javier Villacorta Pérez ◽  
Ernesto Martinez Martinez ◽  
Victoria Cachofeiro ◽  
Ana Tato ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Disease Progression ◽  
Renin Angiotensin System ◽  
Tnf Receptor ◽  
Renal Disease Progression ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Type 2 Diabetic

scholarly journals Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension

Diabetologia ◽  
1997 ◽  
Vol 40 (2) ◽  
pp. 193-199 ◽  
Author(s):  
J. Ringel ◽  
J. Beige ◽  
R. Kunz ◽  
A. Distler ◽  
A. M. Sharma
Keyword(s):  
Diabetic Nephropathy ◽  
Genetic Variants ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin
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