scholarly journals Correction to: Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Wang ◽  
Liming Zhu ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Histone Methyltransferase ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Wang ◽  
Liming Zhu ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
B Cell Lymphoma ◽  
Histone Methyltransferase ◽  
Chemotherapeutic Agents ◽  
Cancer Cell Apoptosis ◽  
Active Transcription

AbstractWHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. In this study, we revealed how WHSC1 regulates tumorigenesis and chemosensitivity of colorectal cancer (CRC). Our data showed that WHSC1 as well as H3K36me2 were highly expressed in clinical CRC samples, and high WHSC1 expression is associated with poorer prognosis in CRC patients. WHSC1 reduction promoted colon cancer cell apoptosis both in vivo and in vitro. We found that B cell lymphoma-2 (BCL2) expression, an anti-apoptotic protein, is markedly decreased in after WHSC1 depletion. Mechanistic characterization indicated that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level. What’s more, our study indicated that WHSC1 depletion promotes chemosensitivity in CRC cells. Together, our results suggested that WHSC1 and H3K36me2 modification might be optimal therapeutic targets to disrupt CRC progression and WHSC1-targeted therapy might potentially overcome the resistance of chemotherapeutic agents.

Bax and Bak are the critical complementary effectors of colorectal cancer cell apoptosis by chemopreventive resveratrol

2006 ◽  
Vol 17 (4) ◽  
pp. 471-478 ◽  
Author(s):  
Thorsten P??hland ◽  
Sascha Wagner ◽  
Mojgan Mahyar-Roemer ◽  
Klaus Roemer
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Apoptosis

Liensinine perchlorate inhibits colorectal cancer tumorigenesis by inducing mitochondrial dysfunction and apoptosis

2018 ◽  
Vol 9 (11) ◽  
pp. 5536-5546 ◽  
Author(s):  
Yang Wang ◽  
Yang-Jia Li ◽  
Xiao-Hui Huang ◽  
Can-Can Zheng ◽  
Xing-Feng Yin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dysfunction ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Quantitative Proteomics ◽  
Food Source ◽  
Colorectal Cancer Cell ◽  
Functional Screen ◽  
Cancer Cell Apoptosis

Functional screen and quantitative proteomics reveal that food-source liensinine induces colorectal cancer cell apoptosisviathe JNK-mitochondrial dysfunction signaling pathway.

scholarly journals SHU00238 Promotes Colorectal Cancer Cell Apoptosis Through miR-4701-3p and miR-4793-3p

2020 ◽  
Vol 10 ◽  
Author(s):  
Haoyu Wang ◽  
Yurui Ma ◽  
Yifan Lin ◽  
Rui Chen ◽  
Bin Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway

2013 ◽  
Vol 42 (3) ◽  
pp. 1018-1026 ◽  
Author(s):  
CHONG-ZHI WANG ◽  
TYLER D. CALWAY ◽  
XIAO-DONG WEN ◽  
JACOB SMITH ◽  
CHUNHAO YU ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Scutellaria Baicalensis ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Apoptosis

Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

2013 ◽  
Vol 1830 (8) ◽  
pp. 4053-4064 ◽  
Author(s):  
Hang-Lung Chang ◽  
Chih-Yu Chen ◽  
Ya-Fen Hsu ◽  
Wen-Shin Kuo ◽  
George Ou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Colorectal Cancer Cell ◽  
Signaling Cascade ◽  
Cancer Cell Apoptosis
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