Sensitivity and specificity of pseudocolor ultrawide field imaging in comparison to wide field fundus fluorescein angiography in detecting retinal neovascularization in diabetic retinopathy

Eye ◽  
2021 ◽  
Author(s):  
Swathy Haridas ◽  
Swati Indurkhya ◽  
Sailesh Kumar ◽  
Anantharaman Giridhar ◽  
Sobha Sivaprasad
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Sensitivity And Specificity ◽  
Retinal Neovascularization ◽  
Wide Field ◽  
Fundus Fluorescein Angiography ◽  
Field Imaging ◽  
Ultrawide Field Imaging

scholarly journals Role of Optical Coherence Tomography Angiography to differentiate Intraretinal microvascular abnormalities and retinal neovascularization in Diabetic Retinopathy

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Abdul Sami Memon ◽  
Nasir Ahmed Memon ◽  
Pir Salim Mahar
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Clinical Diagnosis ◽  
Proliferative Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Neovascularization ◽  
Wide Field ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography

Objective: To assess proliferative diabetic retinopathy (PDR) and to describe the difference in angiographic representation of new vessels (NVs) and Intra retinal microvascular abnormalities (IRMA) on optical coherence tomography angiography (OCTA). Methods: A cross-sectional observational study was performed at ISRA Postgraduate Institute of Ophthalmology, Karachi, from March 2018 to September 2018. Forty-two eyes of 21 patients with history of diabetes mellitus (DM) were examined. Twenty-eight eyes with a clinical diagnosis of severe non proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) according to early treatment diabetic retinopathy study (ETDRS) were included and evaluated using Swept source optical coherence tomography angiography (SS-OCTA). Then face wide field SS-OCTA images and co registered structural optical coherence tomography (OCT) with flow overlay were used to distinguish the features of IRMA and retinal NVs. Results: Forty-two eyes (21 patients) were examined clinically. Fourteen eyes had moderate NPDR, 15 had severe NPDR and 13 eyes had changes consistent with PDR. After clinical diagnosis, we included 28 eyes in our study based on inclusion criteria. These 28 eyes went through SS-OCTA evaluation and we observed 15 cases with PDR and 13 with severe NPDR changes. The OCTA and clinical diagnosis were similar except in 2 eyes, which is critical but not statically significant showing the importance of this noninvasive technology. Conclusions: Widefield OCTA can work as an alternative to fundus fluorescein angiography (FFA) in the diagnosis of diabetic retinopathy (DR). As it is a non-invasive and depth encoded technique so can be used frequently to monitor the retinal changes and their progression. doi: https://doi.org/10.12669/pjms.38.1.3891 How to cite this:Memon AS, Memon NA, Mahar PS. Role of Optical Coherence Tomography Angiography to differentiate Intraretinal microvascular abnormalities and retinal neovascularization in Diabetic Retinopathy. Pak J Med Sci. 2022;38(1):---------.  doi: https://doi.org/10.12669/pjms.38.1.3891 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals ULTRA–WIDE-FIELD IMAGING AND INTRAVENOUS FUNDUS FLUORESCEIN ANGIOGRAPHY IN INFANTS WITH RETINOPATHY OF PREMATURITY

Retina ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 2357-2365
Author(s):  
Jianbo Mao ◽  
Yirun Shao ◽  
Jimeng Lao ◽  
Xueting Yu ◽  
Yiqi Chen ◽  
...  
Keyword(s):  
Fluorescein Angiography ◽  
Retinopathy Of Prematurity ◽  
Wide Field ◽  
Fundus Fluorescein Angiography ◽  
Field Imaging ◽  
Wide Field Imaging

scholarly journals Ultra-wide-field fluorescein angiography in diabetic retinopathy: a narrative review

2017 ◽  
Vol Volume 11 ◽  
pp. 803-807 ◽  
Author(s):  
Alessandro Rabiolo ◽  
Mariacristina Parravano ◽  
Lea Querques ◽  
Maria Vittoria Cicinelli ◽  
Adriano Carnevali ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Narrative Review ◽  
Wide Field

scholarly journals Fluorescein Angiography, Wide Field Angiography, and Indocyanine Green Angiography in Behcet Uveitis

2018 ◽  
pp. 334-337
Keyword(s):  
Early Diagnosis ◽  
Indocyanine Green ◽  
Fluorescein Angiography ◽  
Indocyanine Green Angiography ◽  
Ocular Involvement ◽  
Wide Field ◽  
Fundus Examination ◽  
Fundus Fluorescein Angiography ◽  
Important Place ◽  
Retinal Periphery

In Behcet's disease, the anterior and posterior segments of the eye may be affected separately or together. Fundus fluorescein angiography should be performed in addition to ophthalmoscopic examination for early diagnosis and treatment of ocular involvement. Fundus fluorescein angiography (FFA) is the gold standard for the evaluation of the retinal vascular system and pathologies. Fundus fluorescein angiography is more sensitive than fundus examination in the detection of vasculitis, and angiographic involvement is always more common than clinical involvement. Fluorescein angiography may reveal leakage from retinal veins in eyes whose visual impression is not affected and the fundus examination is normal. The absence of vascular leakage with fluorescein angiography indicates that the disease is in a completely inactive period. Because of the development of blindness due to posterior segment involvement, early detection of the disease with fundus angiography and the initiation of the treatment is successful in terms of visual prognosis. It has an important place in terms of early activation of patients with FFA in the early diagnosis of eye involvement and follow-up of the disease and treatment. Wide-field imaging angiography imaging of the retinal periphery revealed the importance of lesions in retinal periphery and peripheral areas invisible by standard angiography. The use of indocyanine green angiography in Behcet uveitis is limited.

Ultra-Wide Field Imaging Characteristics of Primary Retinal Vasculitis: Risk Factors for Retinal Neovascularization

2018 ◽  
Vol 27 (3) ◽  
pp. 383-388 ◽  
Author(s):  
Abhishek Sheemar ◽  
Shreyas Temkar ◽  
Brijesh Takkar ◽  
Rita Sood ◽  
Sanjeev Sinha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Vasculitis ◽  
Retinal Neovascularization ◽  
Wide Field ◽  
Imaging Characteristics ◽  
Field Imaging ◽  
Wide Field Imaging

Retinal vascular bed area on ultra-wide field fluorescein angiography indicates the severity of diabetic retinopathy

2021 ◽  
pp. bjophthalmol-2020-317488
Author(s):  
Wenying Fan ◽  
Akihito Uji ◽  
Muneeswar Nittala ◽  
Charles Clifton Wykoff ◽  
David Brown ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Final Analysis ◽  
Retinal Vasculature ◽  
Wide Field ◽  
Link Type ◽  
Vascular Bed ◽  
Retinal Ischaemia ◽  
Reading Center ◽  
Normal Controls

AimsTo quantify retinal vascular bed area (RVBA) in square millimetres on stereographically projected ultra-wide field (UWF) fluorescein angiography (FA) in eyes with diabetic retinopathy (DR).MethodsA prospective, observational study. Baseline Optos 200Tx UWF FA images of 80 eyes with DR from the DAVE (NCT01552408) and RECOVERY (NCT02863354) studies were stereographically projected at the Doheny Image Reading Center to adjust for peripheral distortion. The early-phase FA frame was used to extract the retinal vasculature as a mask for calculating RVBA. The pixels of the retinal vasculature were automatically computed in square millimetres using manufacturer-provided software.ResultsEighteen of 80 diabetic eyes were excluded because image quality and contrast were insufficient for automatic extraction of the retinal vasculature from the background fluorescence. The remaining 62 eyes were included in the final analysis. In comparison with age-matched and sex-matched normal controls, eyes with DR had a higher global RVBA for the entire retina (p<0.001), and RVBA correlated with DR severity (p<0.001), with a higher RVBA in eyes with proliferative DR (66.1±16.2 mm2) than in those with non-proliferative DR (56.2±16.6 mm2) or in normal controls (37.2±9.9 mm2). This tendency was also present in the posterior retina and mid-periphery but absent in the far-periphery. RVBA did not correlate with retinal ischaemia (p>0.05).ConclusionsEyes with DR harboured a larger global RVBA for the entire retina than normal controls, and RVBA appeared to indicate DR severity. However, this biomarker was not observed to be a good indicator of retinal ischaemia.

Imaging in diabetic retinopathy

2020 ◽  
pp. 161-170
Author(s):  
Sarita Jacob ◽  
Ramesh R. Sivaraj
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Prognostic Value ◽  
Diabetic Macular Oedema ◽  
Imaging Modalities ◽  
Wide Field ◽  
Optical Coherence ◽  
Diabetic Maculopathy ◽  
Fundus Fluorescein Angiography ◽  
Diagnostic And Prognostic Value

Imaging in diabetic retinopathy (DR) has developed over the years and the advantages are multifold. Various imaging modalities are currently available, which is of great diagnostic and prognostic value in the management of DR. Optical coherence tomography (OCT) has revolutionized the management of diabetic maculopathy. OCT has now become indispensable for initiating and assessing diabetic macular oedema (DMO) while on treatment with intravitreal injections. Recent introduction of optical coherence tomography angiography (OCTA) has significantly reduced the need for fundus fluorescein angiography (FFA) for macular ischaemia and proliferative retinopathy. Ultra-wide field (UWF) imaging modalities for colour fundus and UWF FFA are very useful to document and assess overall retinal state highlighting the periphery. Bscan ultrasonography of the fundus is an useful tool to assess retinal status in proliferative DR with vitreous haemorrhage.

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