Noninvasive central systolic blood pressure, not peripheral systolic blood pressure, independently predicts the progression of carotid intima-media thickness in a Chinese community-based population

It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r=0.25,P=0.007), systolic blood pressure (r=0.19,P=0.009), pulse pressure (r=0.30,P=0.001), and LDL-cholesterol (r=0.19,P=0.043). cIMT was correlated to CRP (r=0.31,P=0.007) and negatively correlated to HDL-cholesterol (r=0.33,P=0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women.

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The association between carotid intima-media thickness and new-onset hypertension in a Chinese community-based population

BMC Cardiovascular Disorders ◽

10.1186/s12872-019-1266-1 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Long Zhang ◽

Fangfang Fan ◽

Litong Qi ◽

Jia Jia ◽

Ying Yang ◽

...

Keyword(s):

Blood Pressure ◽

Strong Association ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Incidence Rates ◽

Community Based ◽

Media Thickness ◽

The Mean ◽

New Onset

Abstract Background Hypertension and arterial vasculopathy may be mutual causes and effects. It is unknown whether carotid intima-media thickness (cIMT) is reliably predictive of the presence of newly developed hypertension in the Chinese population. This study evaluated the impacts of cIMT on new-onset hypertension in a community-based population without hypertension at baseline in China. Methods A total of 672 Chinese subjects who had complete data for demographics, baseline and follow-up blood pressure measurements, and cIMT measurements at baseline were included in our study. Baseline cIMT was obtained under standardized procedures using the GE Vivid 7 ultrasound system equipped with an 8-MHz linear array vascular probe (GE Medical Systems, Milwaukee, Wl, USA). The outcome was the incidence of hypertension at follow-up. Multivariate regression models were used to access the association between baseline cIMT and the risk of new-onset hypertension. Results Subjects were 51.5 ± 4.7 years old, and 32.0% were male. The mean baseline systolic blood pressure (SBP) was 122.5 ± 10.0 mmHg. The mean baseline diastolic blood pressure (DBP) was 72.4 ± 7.5 mmHg. The number of subjects with thickened cIMT (maximum ≥0.9 mm) at baseline was 198 (29.5%). After 2.3 years of follow-up, the rate of new-onset hypertension was 12.6%. The incidence rates of hypertension in the groups with thickened cIMT and normal cIMT were 19.2 and 9.9%, respectively. In the multivariable logistic regression analyses, both the average (OR = 1.69, 95% CI: 1.30–2.19, P = 0.0001) and maximum (OR = 1.55, 95% CI: 1.23–1.95, P = 0.0002) cIMT were significantly associated with new-onset hypertension after adjustment for various confounders. The group with thickened cIMT showed a higher risk for the incidence of hypertension, with an OR of 1.82 (95% CI: 1.07–3.10, P = 0.0270), compared to the normal group. Conclusion Thickened cIMT has a strong association with incident hypertension risk in a community-based population without hypertension at baseline in China.

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Noninvasive Central Systolic Blood Pressure Is More Strongly Related to Kidney Function Decline Than Peripheral Systolic Blood Pressure in a Chinese Community–Based Population

Hypertension ◽

10.1161/hypertensionaha.115.07019 ◽

2016 ◽

Vol 67 (6) ◽

pp. 1166-1172 ◽

Cited By ~ 30

Author(s):

Fangfang Fan ◽

Litong Qi ◽

Jia Jia ◽

Xin Xu ◽

Yan Liu ◽

...

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Kidney Function ◽

Chinese Community ◽

Community Based ◽

Central Systolic Blood Pressure ◽

Kidney Function Decline

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Remodeling of Retinal Microcirculation Is Associated With Subclinical Arterial Injury in Hypertensive Children

Hypertension ◽

10.1161/hypertensionaha.120.16734 ◽

2021 ◽

Vol 77 (4) ◽

pp. 1203-1211

Author(s):

Anna Rogowska ◽

Łukasz Obrycki ◽

Zbigniew Kułaga ◽

Claudia Kowalewska ◽

Mieczysław Litwin

Keyword(s):

Blood Pressure ◽

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Ganglion Cell Complex ◽

Fiber Layer ◽

Foveal Thickness ◽

Media Thickness ◽

Central Systolic Blood Pressure

The aim of the study was to assess the relationship between hypertensive target organ damage and vessel density (VD), foveal thickness, thickness of retinal nerve fiber layer, ganglion cell complex, and foveal avascular zone (FAZ) using optical coherence tomography angiography in a nonselected group of hypertensive children. One hundred fifty-seven children (56 girls) in mean age 14.9±2.9 years, in whom arterial hypertension was ultimately diagnosed were included in the study. FAZ, whole, fovea, parafovea superficial VD, whole, fovea, parafovea deep VD, foveal thickness, retinal nerve fiber layer, and ganglion cell complex were taken into analysis. Both absolute and standardized values of carotid intima-media thickness correlated with the larger FAZ area ( P =0.035, r =0.17; P =0.01, r =0.2, respectively). Subjects with increased carotid intima-media thickness had significantly larger FAZ ( P =0.024), reduced fovea superficial VD ( P =0.039), and foveal thickness ( P =0.007). Left ventricular hypertrophy and increased carotid-femoral pulse wave velocity were not associated with optical coherence tomography angiography parameters. Multiple linear regression revealed that the only determinant of FAZ and foveal thickness was higher carotid intima-media thickness–SD score, and for fovea superficial VD, the only determinant was central systolic blood pressure. In conclusion, hypertensive children present with signs of remodeling of microcirculation and decreased neural layer of retina associated with hypertensive macrocirculation remodeling expressed as increased carotid intima-media thickness and elevated central systolic blood pressure.

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