Adverse effects and potential benefits among selective androgen receptor modulators users: a cross-sectional survey

2021 ◽  
Author(s):  
Iakov V. Efimenko ◽  
David Valancy ◽  
Justin M. Dubin ◽  
Ranjith Ramasamy
Keyword(s):  
Androgen Receptor ◽  
Adverse Effects ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Selective Androgen Receptor Modulators ◽  
Potential Benefits ◽  
Receptor Modulators

scholarly journals Socioeconomic Inequities in Youth Participation in Physical Activity and Sports

2021 ◽  
Vol 18 (13) ◽  
pp. 6946
Author(s):  
Pooja S. Tandon ◽  
Emily Kroshus ◽  
Katharine Olsen ◽  
Kimberly Garrett ◽  
Pingping Qu ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sports Participation ◽  
Youth Participation ◽  
Cross Sectional Survey ◽  
Middle School Children ◽  
Cross Sectional ◽  
Potential Benefits ◽  
Physical Activity Recommendations ◽  
High Schoolers ◽  
Activity Recommendations

Access to opportunities for physical activity and sports, and therefore potential benefits of participation, are distributed inequitably. The aims of this study were to describe and compare youth experiences related to sport and physical activity by socioeconomic factors. A cross-sectional survey was conducted of students in 5–12th grades in King County, Washington, USA. Students were asked about physical activity and sports experiences and about demographic factors including family affluence, which was categorized as low, medium, and high. Participants were 1038 youth (50% girls, 58% non-White, and 32% from homes where languages other than English are spoken). Children from low-affluence families reported fewer days/week of physical activity, fewer sports sampled, and lower rates of ever playing sports. Greater proportions of children from low-affluence families reported these barriers to sports: (1) don’t want to get hurt, (2) don’t feel welcome on teams, (3) too expensive, and (4) transportation. Middle school children from high-affluence families had three times higher odds of meeting physical activity recommendations, and high-affluence high schoolers had three times higher odds of ever participating in sports compared to peers from low-affluence families. Socioeconomic status was inversely associated with outcomes related to youth physical activity and sports participation. The disproportionately reported barriers to sports participation are modifiable, and cross-sector solutions can help promote play equity.

A Survey of Neonatal Nurses on Mydriatic Regimens Used in Neonatal Retinopathy of Prematurity Eye Examinations

2021 ◽  
Author(s):  
Lisa Kremer ◽  
David Reith ◽  
Natalie J. Medlicott ◽  
Mary J. Sime ◽  
Liza Edmonds ◽  
...  
Keyword(s):  
New Zealand ◽  
Adverse Effects ◽  
Retinopathy Of Prematurity ◽  
Adverse Drug Events ◽  
Preterm Neonates ◽  
Eye Drops ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Aotearoa New Zealand ◽  
Adult Dose

Objective This study was aimed to determine mydriatic regimen(s) used in neonatal units in Aotearoa New Zealand (NZ) and Australia and to estimate the frequency of adverse drug events following mydriatic administration in preterm neonates. Study Design A cross-sectional survey was sent to neonatal nursing staff listed in the Australian and New Zealand Neonatal Network contact list. Participants were asked to state what mydriatic regimen they use, and to estimate the frequency of adverse drug events when eye drops were administered for retinopathy of prematurity eye examinations (ROPEE). Results Thirteen different mydriatic regimens were identified; phenylephrine 2.5% and cyclopentolate 0.5% (1 standard drop of each) was the most commonly used regimen. Two of the regimens exceeded adult doses and five regimens included a mydriatic that is equivalent to an adult dose. Following mydriatic instillation, the three most common adverse effects were apnea, tachycardia, and periorbital pallor. Conclusion Low-concentration single-microdrop regimens are currently in use and resulting in successful ROPEE, yet doses exceeding adult doses are in use throughout Aotearoa NZ and Australian units. We know from this dataset that neonates are experiencing unwanted and potentially preventable, adverse effects associated with mydriatics, and every effort should be made to minimize this risk. Key Points

scholarly journals Patients’ attitudes toward conventional and herbal treatments for depression and anxiety: A cross-sectional Israeli survey

2021 ◽  
pp. 002076402199238
Author(s):  
Or Burstein ◽  
Alon Shamir ◽  
Nurit Abramovitz ◽  
Ravid Doron
Keyword(s):  
Adverse Effects ◽  
Large Scale ◽  
Prescription Medications ◽  
Depression And Anxiety ◽  
Cultural Backgrounds ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Cultural Aspects ◽  
Final Sample ◽  
Choice Of Treatment

Background: As many patients view conventional antidepressants and anxiolytics negatively, it is not surprising that the willingness to apply these treatments is far from ideal, thus posing a critical barrier in promoting an effective and durable treatment. Aim: The present study aimed to explore patients’ attitudes toward conventional and herbal treatments for depression and anxiety, while considering cultural and demographic factors, to further elucidate the antecedes that putatively determine the treatment’s outcome. Methods: During June 2017, a cross-sectional survey was conducted using stratified sampling from a large-scale Israeli volunteer online panel. The final sample included 591 Jewish Israeli adults that reported they were suffering from depression or anxiety. Results: A heterogeneous range of attitudes toward treatment was found: for example, a large group of patients did not utilize prescription medications (39%), a professional consultation (12.9%), or any form of treatment (17.4%). Interestingly, these patients were significantly more likely to support naturally-derived treatments and were less concerned with scientific proof. Further, adverse effects were demonstrated as a prominent factor in the choice of treatment. A higher incidence of adverse effects was associated with an increased willingness to consider an alternative herbal treatment. Noteworthy attitudes were found in orthodox-Jewish individuals, who showed similar consultation rates, but utilized more psychological, rather than pharmacological treatments. Conclusions: It is proposed that patients’ perspectives and cultural backgrounds are needed to be taken into consideration during the clinical assessment and choice of treatment. The findings imply that a particular emphasis should be placed on patients that discard conventional pharmacological options and on distinct cultural aspects. Several recommendations for revising the current policy are advocated to promote more culturally-informed and patient-oriented care.

scholarly journals Safety and Use of Complementary and Alternative Medicine in Norway During the First Wave of the COVID-19 Pandemic Using an Adapted Version of the I-CAM-Q: A Cross-Sectional Survey

2021 ◽  
Author(s):  
Agnete Egilsdatter Kristoffersen ◽  
Miek C. Jong ◽  
Johanna Hök Nordberg ◽  
Esther T. van der Werf ◽  
Trine Stub
Keyword(s):  
Adverse Effects ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Well Being ◽  
Computer Assisted ◽  
Fisher Exact Test ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Exact Test ◽  
Complementary And Alternative

Abstract BackgroundThe COVID-19 pandemic lockdown has had a profound impact on physical and mental well-being throughout the world. Previous studies have revealed that complementary and alternative medicine (CAM) is frequently used for, and can be potential beneficial for strengthening physical mental resilience. The aim of this study was therefore to determine the prevalence, associations and reasons for use of CAM during the first wave of the COVID-19 pandemic among a representative sample of the Norwegian population, and determine possible effects and adverse effects of the treatments. MethodsComputer assisted telephone interviews using a COVID-adapted I-CAM-Q questionnaire were conducted with 1008 randomly selected Norwegians aged 16 and above using multistage sampling during April and May 2020 applying age and sex quotas for each area. Descriptive statistics were carried out using Pearson’s Chi-square test, Fisher exact test, and Independent samples T-tests to identify group differences. ResultsThe study revealed that two thirds of the respondents (67%) had used CAM within the first three months of the COVID-19 pandemic, in particular CAM modalities that did not involve a provider. Most used were natural remedies and dietary supplement (57%, mainly vitamins and minerals), but self-help practices like yoga and meditation were also widely used (24%). Women used CAM modalities significantly more than men (77% vs. 58%). Most of the respondents found the modalities they used beneficial, and 5% reported adverse effects of the treatments.ConclusionsThe first wave of the COVID-19 pandemic has not profoundly changed the overall need of Norwegian citizens to seek care outside the conventional healthcare system, but rather caused a shift in the type of CAM modalities used. The risk profile of these modalities was generally low as only 5 % of the respondents reported adverse effects. Further studies are needed to confirm the change from provider based to self-administered CAM use.

Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces

2016 ◽  
Vol 9 (7) ◽  
pp. 1017-1025 ◽  
Author(s):  
Dante Rojas ◽  
Gaud Dervilly-Pinel ◽  
Nora Cesbron ◽  
Mylène Penot ◽  
Alexandre Sydor ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bovine Urine ◽  
Selective Androgen Receptor Modulators ◽  
Excretion Study ◽  
Receptor Modulators
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