Common ground: shared risk factors for type 1 diabetes and celiac disease

2018 ◽  
Vol 19 (7) ◽  
pp. 685-695 ◽  
Author(s):  
Elena F. Verdu ◽  
Jayne S. Danska
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Common Ground ◽  
Shared Risk

Vascular risk factors in children, adolescents, and young adults with type 1 diabetes complicated by celiac disease: results from the DPV initiative

2015 ◽  
Vol 17 (3) ◽  
pp. 191-198 ◽  
Author(s):  
Katharina Warncke ◽  
Susanne Liptay ◽  
Elke Fröhlich-Reiterer ◽  
Nicole Scheuing ◽  
Martin Schebek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Celiac Disease ◽  
Vascular Risk Factors ◽  
Adolescents And Young Adults ◽  
Vascular Risk

scholarly journals Prevalence of celiac disease and celiac-related antibody status in pediatric patients with type 1 diabetes in Jordan

2019 ◽  
Vol 8 (6) ◽  
pp. 780-787 ◽  
Author(s):  
Rasha Odeh ◽  
Abeer Alassaf ◽  
Lubna Gharaibeh ◽  
Sarah Ibrahim ◽  
Fareed Khdair Ahmad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Pediatric Patients ◽  
Arab World ◽  
Duodenal Biopsy ◽  
Positive Serology

Objective Scientific findings regarding the prevalence of celiac disease (CD) in pediatric patients with type 1 diabetes (T1D) in the Arab world are scarce. We aimed to determine the prevalence of biopsy-proven celiac disease (BPCD) among pediatric patients with T1D from Jordan. We also assessed the possible predictors for developing CD in this cohort of patients and we compared T1D patients who developed BPCD with those who had positive CD serology but negative histology and/or fluctuating CD serology. Methods Celiac serology and duodenal biopsy results from 2012 to 2017 were collected from patients with T1D. The outcome of positive celiac serology and the risk factors for CD in T1D patients were investigated. Results A total of 538 children of which 278 boys (51.7%) were included in the study. The prevalence of positive serology and the diagnosis of BPCD in this cohort of T1D patients were 16.6 and 9.1% respectively. Eighty percent of those with BPCD were asymptomatic and 47% were diagnosed with CD at onset of T1D. Spontaneous normalization of celiac serology occurred in 23.6% of those with positive serology. Conclusion CD is prevalent in T1D pediatric patients from Jordan (9.1%). It is often asymptomatic and the majority of cases were diagnosed at onset or within 5 years of T1D diagnosis. Spontaneous normalization of CD serology occurred in some patients with T1D. Hence, a watchful follow-up is recommended in such patients.

scholarly journals Prediction of autoimmune diabetes and celiac disease in childhood by genes and perinatal environment: Design and initial aims of the PAGE study

2014 ◽  
Vol 24 (1-2) ◽  
Author(s):  
Lars C. Stene ◽  
Geir Joner ◽  
Ketil Størdal
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Blood Plasma ◽  
Genetic Risk ◽  
Autoimmune Diabetes ◽  
Genetic Risk Factors ◽  
Host Cells ◽  
Full Cohort

Type 1 diabetes and celiac disease result from misdirected immune mediated destruction of host cells, and are among the most common chronic diseases in children. Despite changes in incidence over the past 3 decades, little is known about non-genetic risk factors (except for dietary gluten for celiac disease). Norway is among the countries in the world with the highest incidence of these two diseases. We describe here plans and study design for the PAGE study (Prediction of Autoimmune diabetes and celiac disease in childhood by Genes and perinatal Environment). PAGE is a sub-study within the Norwegian Mother and Child Cohort study, including follow-up of more than 100,000 pregnancies. Children who develop type 1 diabetes or celiac disease are identified via linkage to the Norwegian Patient Register and the Norwegian Childhood Diabetes Registry, with complementing information from questionnaires. The overall aim is to test hypotheses about potential non-genetic risk factors for type 1 diabetes and for celiac disease, with focus on factors operating early in life. In addition to a full cohort analysis of factors registered in questionnaires, we will analyse biomarkers in maternal blood plasma and cord blood plasma. Mothers and children will be genotyped for well-established susceptibility polymorphisms. Biomarkers will be analysed in cases and controls within the cohort. Factors to be tested in the full cohort include infant feeding, diet and dietary supplements in the mother during pregnancy and in the child, and use of antibiotics and non-prescription drugs. Biomarkers to be tested include 25-hydroxyvitamin D, markers of immune activation, and small metabolites (metabolomics). We will also explore the potential role of maternal cells in the fetal circulation (maternal microchimerism) in later risk of celiac disease and type 1 diabetes.

Celiac disease and risk of subsequent type 1 diabetes

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
É Micskey ◽  
P Pánczél ◽  
L Blatniczky ◽  
K Lukács
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease

Combined analysis of perinatal and infant risk factors for type 1 diabetes

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
R Chmiel ◽  
C Winkler ◽  
A Beyerlein ◽  
M Köhler ◽  
A Knopff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Combined Analysis
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