scholarly journals Retinal S-opsin dominance in Ansell’s mole-rats (Fukomys anselli) is a consequence of naturally low serum thyroxine

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Yoshiyuki Henning ◽  
Nella Mladěnková ◽  
Hynek Burda ◽  
Karol Szafranski ◽  
Sabine Begall
Keyword(s):  
1978 ◽  
Vol 25 (3) ◽  
pp. 275-279 ◽  
Author(s):  
KATSUJI IKEKUBO ◽  
JUNJI KONISHI ◽  
KOTOKO NAKAJIMA ◽  
KEIGO ENDO ◽  
TORU MORI ◽  
...  
Keyword(s):  

2014 ◽  
Vol 13 (3) ◽  
pp. 93-96
Author(s):  
Shaheda Ahmed ◽  
A S M Towhidul Alam

Objective: To review current concepts in the management of subclinical hypothyroidism (SCH) in patients with non-specific symptoms.Data sources: A review of articles reported on overt hypothyroidism and subclinical hypothyroidism. Summary of review: In a patient with primary overt hypothyroidism, management is usually straightforward: treatment with thyroxine should be offered to anyone with characteristic clinical features, a raised serum thyroid stimulating hormone (TSH) concentration and a low serum thyroxine (T4) concentration. More difficult is the management of a patient with subclinical hypothyroidism (SCH), in whom serum TSH is slightly raised (5-20 mIU/L) but T3, T4 levels are normal, and who is either asymptomatic or has only non-specific symptoms. Left untreated, some of these patients will eventually develop overt hypothyroidism. This review will address the use of thyroxine in patients with subclinical hypothyroidism.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i3.21045 


1977 ◽  
Vol 55 (2) ◽  
pp. 288-292 ◽  
Author(s):  
C. H. Bastomsky

Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID, respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (reflecting free T4 in serum) was less in these rats. Both serum triiodothyronine (T3) and the free T3 index were elevated in rats fed PCB in HID. LID-maintained rats had elevated serum T3 concentrations but the free T3 index was similar to that in HID-fed rats, owing to enhanced binding of thyroid hormone to serum proteins. Addition of PCB to LID reduced serum T3 levels but did not alter the free T3 index because binding was less. In rats fed HID containing PCB, thyroid 131I uptake was increased.


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