Validation of systems biology derived molecular markers of renal donor organ status associated with long term allograft function

A transplant between two people who are not genetically identical is called an allotransplant and the process is called allotransplantation. Donor organs and tissues can be from people who are living, or people who have died because of a significant brain injury or lack of circulation. Allotransplantation can create a rejection process where the immune system of the recipient attacks the foreign donor organ or tissue and destroys it. The recipient may need to take immunosuppressive medication for the rest of their life to reduce the risk of rejection of the donated organ. In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. The adverse effects associated with these agents and the risks of long-term immunosuppression present a number of challenges for the clinician. Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism.

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Intragraft Tubular Vimentin and CD44 Expression Correlate With Long-Term Renal Allograft Function and Interstitial Fibrosis and Tubular Atrophy

Transplantation Journal ◽

10.1097/tp.0b013e3181e86b42 ◽

2010 ◽

Vol 90 (5) ◽

pp. 502-509 ◽

Cited By ~ 22

Author(s):

Jesper Kers ◽

Yi-Chun Xu-Dubois ◽

Eric Rondeau ◽

Nike Claessen ◽

Mirza M. Idu ◽

...

Keyword(s):

Renal Allograft ◽

Interstitial Fibrosis ◽

Tubular Atrophy ◽

Cd44 Expression ◽

Allograft Function

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Molecular Mechanisms of Fetal Alcohol Syndrome: Shh-signaling S.C.A. wishes to thank Marianne Bronner-Fraser for her long-term help and support, and Sarah Mahoney and Vijaya Thakur for technical help. Portions of this articles are adapted from Ahlgren et al., 2002. S.C.A. is supported by March of Dimes grant number FY02–134 and National Institutes of Health Grant 7 R21 AA013596–02. S.C.A. is the Crown Family Research Scholar in Developmental Systems Biology.

Comprehensive Handbook of Alcohol Related Pathology ◽

10.1016/b978-012564370-2/50075-1 ◽

2005 ◽

pp. 937-948

Author(s):

SC Ahlgren

Keyword(s):

Systems Biology ◽

Fetal Alcohol Syndrome ◽

Molecular Mechanisms ◽

National Institutes Of Health ◽

Fetal Alcohol ◽

Developmental Systems ◽

Shh Signaling ◽

Research Scholar ◽

March Of Dimes

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Identification of Leukocyte Subpopulations as Potential Biomarkers of Long-term Survival With Normal Allograft Function After Lung Transplantation

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2018.01.518 ◽

2018 ◽

Vol 37 (4) ◽

pp. S212

Author(s):

A. Mendoza-Valderrey ◽

B. Sáez ◽

M.P. Hernández-Fuentes ◽

T. Pereira-Veiga ◽

R. Escobar ◽

...

Keyword(s):

Lung Transplantation ◽

Term Survival ◽

Long Term Survival ◽

Allograft Function ◽

Potential Biomarkers

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Long‐term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression

Brain and Behavior ◽

10.1002/brb3.1508 ◽

2019 ◽

Vol 10 (2) ◽

Author(s):

Han Zhu ◽

Yanlin Tao ◽

Tingting Wang ◽

Jin Zhou ◽

Yingwen Yang ◽

...

Keyword(s):

Molecular Markers ◽

Rodent Models ◽

Term Stability ◽

Long Term Stability

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A májfunkció romlásának rizikófaktorai sikeres vesetranszplantációt követően

Orvosi Hetilap ◽

10.1556/650.2019.31257 ◽

2019 ◽

Vol 160 (5) ◽

pp. 186-190

Author(s):

Bernadett Borda ◽

Attila Nemes ◽

Csaba Lengyel ◽

Tamás Várkonyi ◽

Ferenc Rárosi ◽

...

Keyword(s):

Liver Function ◽

Immunosuppressive Therapy ◽

Liver Enzymes ◽

Graft Loss ◽

Study Results ◽

Allograft Function ◽

The Difference ◽

The Impact ◽

The Relationship

Abstract: Introduction: Increase of liver function is one of the most common complications after kidney transplantation due to the use of immunosuppressive therapy and hyperlipidemia in addition to hepatitis C virus (HCV) infection. Method: Following the selection criteria (n = 59), the study is based on applied immunosuppressive therapy, baseline data of patients, further correlation between HCV and liver function deterioration. Patients were subjected to fasting laboratory examination to monitor serum electrolytes, uric acid and albumin levels. We looked at the effects of immunosuppressive therapy on the lipids (TG, TC, HDL, LDL) and liver enzymes (GOT, GPT, ALP, GGT). The analysis of the relationship between lipids and liver enzymes was also included in our study. Results: The data basics were not significantly different between the tacrolimus and the cyclosporine groups. In the laboratory results, Mg levels were significantly different between the two groups (p = 0.044). The impact of HCV on the liver function was significantly different on GGT (p = 0.008). We examed the lipids and liver function level between the tacrolimus and the patients receiving cyclosporine-based immunosuppression and the total cholesterol (p = 0.005) and GOT (p = 0.05) were significantly different between the two groups. Hyperlipidemia was associated with 26% of patients taking tacrolimus-based immunosuppression, and 89% of those receiving cyclosporine; the difference was significant (p = 0.002). Regarding the effect of hyperlipidemia on liver enzymes, ALP (p = 0.006) and GGT (p = 0.0001) were significantly higher. Conclusion: Increases in hepatic enzymes, ALT and GGT indicate the damage to hepatocytes. Beside the increase of liver function, which is the main risk factor in hepatitis on HCV soil, the applied immunosuppressive therapy and hyperlipidemia lead to degradation of allograft function and long-term graft loss. Orv hetil. 2019; 160(5): 186–190.

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