scholarly journals MiR-23a transcriptional activated by Runx2 increases metastatic potential of mouse hepatoma cell via directly targeting Mgat3

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Huang Huang ◽  
Yubo Liu ◽  
Peishan Yu ◽  
Jianhua Qu ◽  
Yanjie Guo ◽  
...  
Keyword(s):  
Hepatoma Cell ◽  
Metastatic Potential ◽  
Mouse Hepatoma

The CALUX bio-assay: Analytical comparison between mouse hepatoma cell lines with a low (H1L6.1c3) and high (H1L7.5c1) number of dioxin response elements

Talanta ◽  
2011 ◽  
Vol 85 (4) ◽  
pp. 2039-2046 ◽  
Author(s):  
Kersten Van Langenhove ◽  
Kim Croes ◽  
Michael S. Denison ◽  
Marc Elskens ◽  
Willy Baeyens
Keyword(s):  
Cell Lines ◽  
Hepatoma Cell ◽  
Response Elements ◽  
Analytical Comparison ◽  
Hepatoma Cell Lines ◽  
Mouse Hepatoma ◽  
Bio Assay

Simultaneous expression of salivary and pancreatic amylase genes in cultured mouse hepatoma cells

1986 ◽  
Vol 6 (4) ◽  
pp. 969-975
Author(s):  
G J Darlington ◽  
C C Tsai ◽  
L C Samuelson ◽  
D L Gumucio ◽  
M H Meisler
Keyword(s):  
Hepatoma Cell ◽  
Experimental System ◽  
Hepatoma Cells ◽  
Hepatoma Cell Line ◽  
Cell Type ◽  
Specific Expression ◽  
Consensus Sequences ◽  
Mouse Hepatoma ◽  
Amylase Genes

The tissue-specific expression of two types of mouse amylase genes does not overlap in vivo; the Amy-1 locus is transcribed in the parotid gland and the liver, while expression of Amy-2 is limited to the pancreas. We identified a mouse hepatoma cell line, Hepa 1-6, in which both amylase genes can be simultaneously expressed. Amy-1 is constitutively active in these cells and is inducible by dexamethasone at the level of mRNA. We demonstrated that the liver-specific promoter of Amy-1 is utilized by the dexamethasone-treated hepatoma cells, and that glucocorticoid consensus sequences are present upstream of this promoter. Amy-2 is not detectable constitutively, but can be activated if the cells are cultured in serum-free medium containing dexamethasone. Expression of Amy-2 in a nonpancreatic cell type has not previously been observed. We speculate that induction of Amy-1 and activation of Amy-2 may involve different regulatory mechanisms. Hepa 1-6 cells provide an experimental system for molecular analysis of these events.

Sign in / Sign up

Export Citation Format

Share Document