Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates

Aim: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. Methods: Four different analytical methods [AlogP calculation, reverse phase (RP) high-performance liquid chromatography (HPLC; RP-HPLC), size exclusion chromatography HPLC (SEC-HPLC), and differential scanning calorimetry (DSC)] were tested for this comparison. Results: Maytansinoid-based ADCs showed less hydrophobicity than auristatin-based ADCs. Regardless of the drug-linker and drug-to-antibody ratios (DARs), the stability detected by DSC was decreased by conjugation. Conclusions: The cost and time-efficient analytical comparison described in this manuscript may be useful information for an initial characterization of ADCs prior to detailed biological studies.

The New Religious Political Right in Neo-Apartheid South Africa

This article argues that, in similar ways that scholars such as Kaye (1987) and Apple (1990) have respectively demonstrated how post 1970s America and Britain fused the neo-liberal discourse of free markets with the neo-conservative Christian discourse of moral rightness to found a New Right, we can apply this analytical model in post-apartheid/neo-apartheid South Africa. The aim of this analytical comparison is to support the broad claim that the article makes about the rise of the New Right in contemporary South Africa as directly related to the fusion of neo-Pentecostal Christianity with neoliberal economics in very salient ways. Using discourse analysis, the article demonstrates how the New Right in South Africa also draws from the language of crisis to justify a response that brings together the interlocking of race, religion, and neoliberalism. The paper’s main argument is that, a different type of New Right is emerging in current day South Africa, one that is not simply the purview of whitenationalism, but has main appeal also within the black middle-class.

10. Muqadamat e Bagh o Bahar: A Critical Debate And Analytical Comparison

“Muqadamat e Bagh o Bahar” is a supplying scholarly achievement by Dr. Aslam Aziz Durrani. In the beginning of this book, scholarly essay titled as “Pesh Muqadamat” has been presented which includes the artistic aspects etymology, language and analytical comparison of these Muqadamat. Dr Aslam has very artistically put together the analytical views of nine Muqadama Nigars including Mir Aman Dehlvi, John Gilchrist, Molvi Abdul Haq, Mumtaz Hussain, Waqar Azeem, Abul Khair Kashfi, Dr. Mumtaz Manglori, Dr. Saleem Akhtar and Rasheed Hassan Khan. He has done literary postmortem of these Muqadamat so skilfully that the real face of “Bagh o Bahar” is unveiled. The last Muqadama of the said book has been composed by himself which is a vital proof of his love for Muqadma nigari and his grip on the subject.

Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and P-tau231

Introduction Studies using different assays and technologies showed highly promising diagnostic value of plasma phosphorylated (P-)tau levels for Alzheimer’s disease (AD). We aimed to compare six P-tau Simoa assays, including three P-tau181 (Eli Lilly, ADx, Quanterix), one P-tau217 (Eli Lilly), and two P-tau231 (ADx, Gothenburg). Methods We studied the analytical (sensitivity, precision, parallelism, dilution linearity, and recovery) and clinical (40 AD dementia patients, age 66±8years, 50%F; 40 age- and sex-matched controls) performance of the assays. Results All assays showed robust analytical performance, and particularly P-tau217 Eli Lilly; P-tau231 Gothenburg and all P-tau181 assays showed robust clinical performance to differentiate AD from controls, with AUCs 0.936–0.995 (P-tau231 ADx: AUC = 0.719). Results obtained with all P-tau181 assays, P-tau217 Eli Lilly assay, and P-tau231 Gothenburg assay strongly correlated (Spearman’s rho > 0.86), while correlations with P-tau231 ADx results were moderate (rho < 0.65). Discussion P-tau isoforms can be measured robustly by several novel high-sensitive Simoa assays.

AN ANALYTICAL COMPARISON OF MONASTICISM IN SEMITIC RELIGION

Monasticism is voluntary sustain and systemic program of self discipline and self denial in which immediate sensual gratifications are renounced in order to attain some valued spiritual or mental state. Monasticism demands to get away from normal sentiment & human emotions particularly to attain spirituality. Purposes of monasticism are to find out the pure inner self, raise above all flaws & human deficiency, spiritual excellence, liberation, and deliverance. The research paper is an approach to show the comparison between the monastic worlds as revealed through the texts of Semitic religious communities. The comparison of monastic text has the potential to yield a large amount of informative facts. In the areas of asceticism, spirituality, and the balance between sacred and routine life, analogies are numerous and propose many avenues of further comparison still waiting to be explored. The research paper is an approach to show the comparison & in- depth analysis of the Babylonian Talmud, Bible and Quran that find literary analogues in the monastic texts, strategies’, historical examples and suggestions. These examples open the door for a reconsideration of the nature of the relationship between Jews and Christians in the ancient world. This article aimed to highlight the main features of ancient monasticism and to share information in Semitic religion regarding hermit, ascetic and monk. Likewise, this paper also focuses on several processes of changes and transformation of monasticism from a negative view to the enlightenment of identity which lead to the development of a normal and stable society.