scholarly journals Tissue Interlocking Dissolving Microneedles for Accurate and Efficient Transdermal Delivery of Biomolecules

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shayan Fakhraei Lahiji ◽  
Youseong Kim ◽  
Geonwoo Kang ◽  
Suyong Kim ◽  
Seunghee Lee ◽  
...  
2018 ◽  
Vol 541 (1-2) ◽  
pp. 56-63 ◽  
Author(s):  
Aaron R.J. Hutton ◽  
Helen L. Quinn ◽  
Paul J. McCague ◽  
Courtney Jarrahian ◽  
Annie Rein-Weston ◽  
...  

2020 ◽  
Vol 8 (5) ◽  
pp. 928-934 ◽  
Author(s):  
Jinzhu Mao ◽  
Hua Wang ◽  
Ying Xie ◽  
Yangxue Fu ◽  
Yuce Li ◽  
...  

Rapamycin-loaded dissolving microneedles (RAPA DMNs) are fabricated by using polyvinylpyrrolidone (PVP) as the matrix and exhibit the good anti-angiogenic effect.


Drug Delivery ◽  
2020 ◽  
Vol 27 (1) ◽  
pp. 1147-1155 ◽  
Author(s):  
Qinying Yan ◽  
Weiwei Wang ◽  
Jiaqi Weng ◽  
Zhenghan Zhang ◽  
Lina Yin ◽  
...  

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 581 ◽  
Author(s):  
Chung-ryong Jung ◽  
Shayan Fakhraei Lahiji ◽  
Youseong Kim ◽  
Hyeonjun Kim ◽  
Hyungil Jung

Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the stiffness and elastic properties of the skin. Therefore, micropillar integrated DMNs were developed to overcome the insertion limitations of DMN patches. Although micropillars were designed as integrated applicators to implant DMNs across the skin, they can also become inserted into the skin, leading to skin injury and inflammation. Herein, we have developed a separable micropillar integrated DMN (SPDMN) capable of inserting DMNs across the skin with high efficiency while minimizing skin injury risk through the introduction of a safety ring feature. Unlike previously developed systems, the SPDMN does not require continuous skin attachment and can be detached immediately post-application, leaving DMNs implanted inside the skin. Altogether, the findings of this study lead to the development of a quick, safe, and efficient DMN-based drug delivery platform.


2017 ◽  
Vol 534 (1-2) ◽  
pp. 378-386 ◽  
Author(s):  
Gangtao Yao ◽  
Guilan Quan ◽  
Shiqi Lin ◽  
Tingting Peng ◽  
Qingqing Wang ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Na Zhang ◽  
Xinxin Zhou ◽  
Libo Liu ◽  
Lini Zhao ◽  
Hui Xie ◽  
...  

It’s of great significance to develop insulin-loaded dissolving microneedles (MNs) which are fabricated with various methods and materials for transdermal delivery of insulin to effectively and efficiently treat diabetes. In this work, we present a kind of FITC-insulin tip-loaded dissolving MNs fabricated with the mixture of polyvinyl alcohol (PVA) and sucrose using homemade PDMS MNs mold under vacuum conditions. The uniform appearance of MN arrays contributes to controlling the drug dosage well as required. Sufficient mechanical strength for penetrating tough stratum corneum can be obtained by vacuum frozen-drying for at least 6 h after peeling MNs off the mold. About 90% of the FITC-insulin is localized in the conical MN tips and can be released into the skin within 2 min after insertion. The in vivo insulin absorption study and hypoglycemic effect in diabetic mice demonstrate that the proposed insulin-loaded MNs can efficiently deliver the insulin to the systemic circulation and exhibit a similar effect to hypodermic injection on hypoglycemic administration. Together these results suggested that the efficient MN fabrication process proposed in this work shows great potential for mass production and practical application of drug-loaded dissolving MNs in the future.


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