Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients

Introduction: Hyperplastic polyps represent 30–93% of all gastric epithelial polyps. They are generally detected as innocuous incidental findings; however, they have a risk of neoplastic transformation and recurrence. Frequency and risk factors for neoplastic transformation and recurrence are not well established and are fields of ongoing interest. This study aims to evaluate the frequency of and identify the risk factors for recurrence and neoplastic change of gastric hyperplastic polyps (GHP). Methods: A single-centre retrospective cohort study including consecutive patients who underwent endoscopic resection of GHP from January 2009 to June 2020. Demographic, endoscopic, and histopathologic data was retrieved from the electronic medical records. Results: A total of 195 patients were included (56% women; median age 67 [35–87] years). The median size of GHP was 10 (3–50) mm, 62% (n = 120) were sessile, 61% (n = 119) were located in the antrum, and 36% (n = 71) had synchronous lesions. Recurrence rate after endoscopic resection was 23% (n = 26). In multivariate analysis, antrum location was the only risk factor for recurrence (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.1–8.1). Overall, 5.1% (n = 10) GHP showed neoplastic transformation, with low-grade dysplasia in 5, high-grade dysplasia in 4, and adenocarcinoma in 1. In multivariate analysis, a size >25 mm (OR 84; 95% CI 7.4–954) and the presence of intestinal metaplasia (OR 7.6; 95% CI 1.0–55) and dysplasia (OR 86; 95% CI 10–741) in adjacent mucosa were associated with an increased risk of neoplastic transformation. Recurrence was not associated with neoplastic transformation (OR 1.1; 95% CI 0.2–5.9). Discussion: Our results confirmed the risk of recurrence and neoplastic transformation of GHP. Antrum location was a predictor of recurrence. The risk of neoplastic change was increased in large lesions and with intestinal metaplasia and dysplasia in adjacent mucosa. More frequent endoscopic surveillance may be required in these subgroups of GHP.

Download Full-text

The prevalence, risk factors and clinical correlates of diabetes mellitus in Chinese patients with schizophrenia

Schizophrenia Research ◽

10.1016/j.schres.2019.12.029 ◽

2020 ◽

Vol 218 ◽

pp. 262-266 ◽

Cited By ~ 1

Author(s):

Lijuan Huo ◽

Guangya Zhang ◽

Xiang-Dong Du ◽

Qiaqiufang Jia ◽

Zheng-Kang Qian ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Chinese Patients ◽

Clinical Correlates

Download Full-text

Risk factors, microbiological data, and cost of stroke-associated pneumonia: a retrospective study of 331 Chinese patients

Human Health and Medical Engineering ◽

10.2495/hhme130091 ◽

2014 ◽

Author(s):

Zhen-Ni Guo ◽

Si-Yuan He ◽

Jian-Meng Wang ◽

Jie Cao ◽

Yi Yang

Keyword(s):

Risk Factors ◽

Retrospective Study ◽

Chinese Patients ◽

Microbiological Data

Download Full-text

Differences in initial versus recurrent diabetic foot ulcers at a specialized tertiary diabetic foot care center in China

Journal of International Medical Research ◽

10.1177/0300060520987398 ◽

2021 ◽

Vol 49 (1) ◽

pp. 030006052098739

Author(s):

Yuxia Cheng ◽

Ping Zu ◽

Jie Zhao ◽

Lintao Shi ◽

Hongyan Shi ◽

...

Keyword(s):

Risk Factors ◽

Diabetic Foot ◽

Blood Glucose Control ◽

Diabetes Duration ◽

Chinese Patients ◽

Foot Care ◽

Vascular Intervention ◽

History Of ◽

Independent Risk Factors ◽

Recurrence Group

Objective To investigate the characteristics of diabetic foot ulcer (DFU) recurrence. Methods A total of 573 patients with DFUs were recruited and divided into an initial group (395 patients) and a recurrence group (178 patients). The factors related to recurrence were analyzed using multivariate regression. Results The recurrence group had longer diabetes duration (odds ratio [OR] 192; 95% confidence interval 120, 252 vs. 156; 96, 240); lower glycated hemoglobin levels (OR 8.1; 95% CI 6.8, 9.6 vs. 9.1; 7.4, 10.5), and higher rates than the initial group of amputation (37.5% vs. 2.0%), history of vascular intervention (21.3% vs. 3.9%), retinopathy (77.7% vs. 64.7%), callus (44.4% vs. 20.8%), foot deformity (51.2% vs. 24.6%), and outdoor sports shoe wearing (34.0% vs. 21.2%). Multiple factor logistic regression analysis showed that diabetes duration (OR 1.004), callus (OR 2.769), vascular intervention (OR 2.824) and amputation (OR 22.256) were independent risk factors for DFU recurrence. Conclusion Diabetes duration, callus, history of vascular intervention, and amputation were independent risk factors for recurrent DFUs in a cohort of Chinese patients with active DFU. The prevention and treatment of DFUs, especially callus treatment, foot care, and blood glucose control, should be improved in China.

Download Full-text