PEGylated lipid nanocarrier for enhancing photodynamic therapy of skin carcinoma using curcumin: in-vitro/in-vivo studies and histopathological examination

In the present publication, authors have analyzed the results of using sonodynamic and sono-photodynamic therapy with photosensitizing agents of various classes (hematoporphyrin, 5-aminolevulinic acid, chlorin derivatives, etc.) in experimental oncology. In a number of in vitro and in vivo studies, the high antitumor efficacy of the above treatment methods has been proven. Ultrasonic treatment with a pulse frequency of 1–3 MHz and an intensity of 0.7 to 5 W/cm2 , independently and in combination with photo-irradiation of experimental tumors, can significantly improve the cytotoxic properties of photosensitizers. This became the basisfor testing the methodsin patients with malignant neoplasms of various localizations. Scientists fromSouth-East Asia presented the preliminary results of the use of sonodynamic and sono-photodynamic therapy with photosensitizers in the treatment of malignant pathology of the mammary gland, stomach, esophagus, prostate, lung and brain. Analysis of the obtained data indicates the absence of serious adverse events and an increase in the antitumor efficacy of treatment, which included these treatment methods with chlorin-type photosensitizers.

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Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies

British Journal of Cancer ◽

10.1038/sj.bjc.6601722 ◽

2004 ◽

Vol 90 (8) ◽

pp. 1660-1665 ◽

Cited By ~ 42

Author(s):

C Perotti ◽

H Fukuda ◽

G DiVenosa ◽

A J MacRobert ◽

A Batlle ◽

...

Keyword(s):

Photodynamic Therapy ◽

In Vivo Studies ◽

Porphyrin Synthesis

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A novel10B-enriched carboranyl-containing phthalocyanine as a radio- and photo-sensitising agent for boron neutron capture therapy and photodynamic therapy of tumours: in vitro and in vivo studies

Photochemical & Photobiological Sciences ◽

10.1039/b506364g ◽

2006 ◽

Vol 5 (1) ◽

pp. 39-50 ◽

Cited By ~ 32

Author(s):

Elisabetta Friso ◽

Gabrio Roncucci ◽

Donata Dei ◽

Marina Soncin ◽

Clara Fabris ◽

...

Keyword(s):

Photodynamic Therapy ◽

Boron Neutron Capture Therapy ◽

Neutron Capture ◽

In Vivo Studies ◽

Neutron Capture Therapy ◽

Boron Neutron Capture

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Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo

Integrative Cancer Therapies ◽

10.1177/1534735420950468 ◽

2020 ◽

Vol 19 ◽

pp. 153473542095046 ◽

Cited By ~ 1

Author(s):

Mai H. Mekkawy ◽

Hanan A. Fahmy ◽

Ahmed S. Nada ◽

Ola S. Ali

Keyword(s):

Radiation Effects ◽

Histopathological Examination ◽

Ehrlich Ascites Carcinoma ◽

In Vivo Studies ◽

Pon1 Activity ◽

Peroxisome Proliferator ◽

Γ Irradiation ◽

Peroxisome Proliferator Activated Receptor

This study hypothesizes that, bromelain (BL) acts as radiosensitizer of tumor cells and that it protects normal cells from radiation effects. In vitro and in vivo studies have been carried out to prove that assumption. In vitro MTT cell proliferation assay has shown that the irradiated Ehrlich ascites carcinoma (EAC) cell line could be sensitized by BL pretreatment. In vivo: animals were randomly divided into 5 groups, Group 1: control (PBS i.p for 10 days), Group 2: Ehrlich solid tumor (EST) bearing mice, Group 3: EST + γ-radiation (fractionated dose, 1 Gy × 5), Group 4: EST + BL (6 mg/kg, i.p), daily for 10 days, Group 5: EST + BL for 10 days followed by γ-irradiation (1 Gy × 5). The size and weight of tumors in gamma-irradiated EST bearing mice treated with BL decreased significantly with a significant amelioration in the histopathological examination. Besides, BL mitigated the effect of γ-irradiation on the liver relative gene expression of poly ADP ribose polymerase-1 (PARP1), nuclear factor kappa activated B cells (NF-κB), and peroxisome proliferator-activated receptor α (PPAR-α), and it restored liver function via amelioration of paraoxonase1 (PON1) activity, reactive oxygen species (ROS) content, lipid peroxidation (LPO) and serum aspartate transaminase (AST), alanine transaminase (ALT), and albumin (ALB). It is concluded that BL can be considered as a radio-sensitizer and radio-protector, suggesting a possible role in reducing radiation exposure dose during radiotherapy.

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