scholarly journals Sonodynamic and sono-photodynamic therapy in oncology

2019 ◽  
Vol 8 (2) ◽  
pp. 31-46
Author(s):  
D. A. Tzerkovsky ◽  
E. L. Protopovich ◽  
D. S. Stupak
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Pulse Frequency ◽  
Antitumor Efficacy ◽  
In Vivo Studies ◽  
Malignant Neoplasms ◽  
Serious Adverse Events ◽  
Treatment Methods

In the present publication, authors have analyzed the results of using sonodynamic and sono-photodynamic therapy with photosensitizing agents of various classes (hematoporphyrin, 5-aminolevulinic acid, chlorin derivatives, etc.) in experimental oncology. In a number of in vitro and in vivo studies, the high antitumor efficacy of the above treatment methods has been proven. Ultrasonic treatment with a pulse frequency of 1–3 MHz and an intensity of 0.7 to 5 W/cm2 , independently and in combination with photo-irradiation of experimental tumors, can significantly improve the cytotoxic properties of photosensitizers. This became the basisfor testing the methodsin patients with malignant neoplasms of various localizations. Scientists fromSouth-East Asia presented the preliminary results of the use of sonodynamic and sono-photodynamic therapy with photosensitizers in the treatment of malignant pathology of the mammary gland, stomach, esophagus, prostate, lung and brain. Analysis of the obtained data indicates the absence of serious adverse events and an increase in the antitumor efficacy of treatment, which included these treatment methods with chlorin-type photosensitizers. 

scholarly journals Nano-encapsulated tryptanthrin derivative for combined anticancer therapy via inhibiting indoleamine 2,3-dioxygenase and inducing immunogenic cell death

Nanomedicine ◽  
2019 ◽  
Vol 14 (18) ◽  
pp. 2423-2440 ◽  
Author(s):  
Canyu Yang ◽  
Bing He ◽  
Qiang Zheng ◽  
Dakuan Wang ◽  
Mengmeng Qin ◽  
...  
Keyword(s):  
Cell Death ◽  
Single Agent ◽  
Tumor Burden ◽  
Antitumor Efficacy ◽  
In Vivo Studies ◽  
Immunogenic Cell Death ◽  
Indoleamine 2,3 Dioxygenase ◽  
Tumor Tissues

Aim: We developed a polycaprolactone-based nanoparticle (NP) to encapsulate tryptanthrin derivative CY-1-4 and evaluated its antitumor efficacy. Materials & methods: CY-1-4 NPs were prepared and evaluated for their cytotoxicity and associated mechanisms, indoleamine 2,3-dioxygenase (IDO)-inhibitory ability, immunogenic cell death (ICD)-inducing ability and antitumor efficacy. Results: CY-1-4 NPs were 123 nm in size. In vitro experiments indicated that they could both induce ICD and inhibit IDO. In vivo studies indicated that a medium dose reduced 58% of the tumor burden in a B16-F10-bearing mouse model, decreased IDO expression in tumor tissues and regulated lymphocytes subsets in spleen and tumors. Conclusion: CY-1-4 is a potential antitumor candidate that could act as a single agent with combined functions of IDO inhibition and ICD induction.

In vitro and in vivo studies of pharmacokinetics and antitumor efficacy of D07001-F4, an oral gemcitabine formulation

2012 ◽  
Vol 71 (2) ◽  
pp. 379-388 ◽  
Author(s):  
Wei-Hua Hao ◽  
Jong-Jing Wang ◽  
Shu-Ping Hsueh ◽  
Pei-Jing Hsu ◽  
Li-Chien Chang ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
In Vivo Studies

The influence of photodynamic therapy parameters on the inactivation of Candida spp: in vitro and in vivo studies

Laser Physics ◽  
2014 ◽  
Vol 24 (4) ◽  
pp. 045601 ◽  
Author(s):  
F Alves ◽  
E G Mima ◽  
L N Dovigo ◽  
V S Bagnato ◽  
J H Jorge ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Vivo Studies ◽  
Candida Spp

scholarly journals Photodynamic diagnosis and photodynamic therapy of colorectal cancer in vitro and in vivo

RSC Advances ◽  
2020 ◽  
Vol 10 (68) ◽  
pp. 41560-41576
Author(s):  
Nokuphila Winifred Nompumelelo Simelane ◽  
Cherie Ann Kruger ◽  
Heidi Abrahamse
Keyword(s):  
Colorectal Cancer ◽  
Photodynamic Therapy ◽  
Photodynamic Diagnosis ◽  
Treatment Methods

This review highlights the various photo diagnostic and treatment methods utilized for CRC, over the last seven years.

scholarly journals Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies

2015 ◽  
Vol 99 (9) ◽  
pp. 4031-4043 ◽  
Author(s):  
Mariusz Grinholc ◽  
Joanna Nakonieczna ◽  
Grzegorz Fila ◽  
Aleksandra Taraszkiewicz ◽  
Anna Kawiak ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
In Vivo Studies ◽  
Antimicrobial Photodynamic Therapy

scholarly journals Biocompatible Nanoparticles as a Platform for Enhancing Antitumor Efficacy of Cisplatin–Tetradrine Combination

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Fangcen Liu ◽  
Xinyue Wang ◽  
Qin Liu ◽  
Huan Zhang ◽  
Li Xie ◽  
...  
Keyword(s):  
Side Effects ◽  
Double Emulsion ◽  
Antitumor Efficacy ◽  
In Vivo Studies ◽  
Pet Ct ◽  
Pharmacokinetic Properties ◽  
Metabolic Activities ◽  
Fdg Pet Ct

AbstractCombination therapy has been a standard strategy in the clinical tumor treatment. We have demonstrated that combination of Tetradrine (Tet) and Cisplatin (CDDP) presented a marked synergistic anticancer activity, but inevitable side effects limit their therapeutic concentration. Considering the different physicochemical and pharmacokinetic properties of the two drugs, we loaded them into a nanovehicle together by the improved double emulsion method. The nanoparticles (NPs) were prepared from the mixture of poly(ethyleneglycol)–polycaprolactone (PEG–PCL) and polycarprolactone (HO-PCL), so CDDP and Tet can be located into the NPs simultaneously, resulting in low interfering effect and high stability. Images from fluorescence microscope revealed the cellular uptake of both hydrophilic and hydrophobic agents delivered by the NPs. In vitro studies on different tumor cell lines and tumor tissue revealed increased tumor inhibition and apoptosis rates. As to the in vivo studies, superior antitumor efficacy and reduced side effects were observed in the NPs group. Furthermore, 18FDG-PET/CT imaging demonstrated that NPs reduced metabolic activities of tumors more prominently. Our results suggest that PEG–PCL block copolymeric NPs could be a promising carrier for combined chemotherapy with solid efficacy and minor side effects.

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