scholarly journals Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Türküler Özgümüş ◽  
Oksana Sulaieva ◽  
Leon Eyrich Jessen ◽  
Ruchi Jain ◽  
Henrik Falhammar ◽  
...  
Keyword(s):  
Dna Repair ◽  
Type 1 Diabetes ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Diabetes Duration ◽  
Chronic Hyperglycemia ◽  
Increased Risk ◽  
Term Type

AbstractType 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia and diabetes duration have been considered as the major risk factors for vascular complications, this is not universally seen among all patients. Persons with long-term type 1 diabetes who have remained largely free from vascular complications constitute an ideal group for investigation of natural defense mechanisms against prolonged exposure of diabetes. Transcriptomic signatures obtained from RNA sequencing of the peripheral blood cells were analyzed in non-progressors with more than 30 years of diabetes duration and compared to the patients who progressed to microvascular complications within a shorter duration of diabetes. Analyses revealed that non-progressors demonstrated a reduction in expression of the oxidative phosphorylation (OXPHOS) genes, which were positively correlated with the expression of DNA repair enzymes, namely genes involved in base excision repair (BER) machinery. Reduced expression of OXPHOS and BER genes was linked to decrease in expression of inflammation-related genes, higher glucose disposal rate and reduced measures of hepatic fatty liver. Results from the present study indicate that at transcriptomic level reduction in OXPHOS, DNA repair and inflammation-related genes is linked to better insulin sensitivity and protection against microvascular complications in persons with long-term type 1 diabetes.

scholarly journals Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study

2021 ◽  
Author(s):  
Elke R. Fahrmann ◽  
Laura Adkins ◽  
Henry K. Driscoll
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Severe Hypoglycemia ◽  
Vascular Damage ◽  
Diabetes Duration ◽  
Ischemic Heart

OBJECTIVE <p>Literature suggests that severe hypoglycemia (SH) may be linked to cardiovascular events only in older individuals with high cardiovascular risk score (CV-score). Whether a potential relationship between any-SH and cardiovascular disease exists and whether it is conditional on vascular damage severity in a young type 1 diabetes (T1D) cohort without apparent macro-vascular and no or mild-to-moderate micro-vascular complications at baseline is unknown.</p> <p>RESEARCH DESIGN AND METHODS</p> <p>We evaluated data of 1441 Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) volunteers (diabetes duration 1-15 years) followed for ~30 years. Time-dependent associations between any-SH, interactions of any-SH with surrogates of baseline micro-/macro- vascular damage severity (diabetes duration, Early Treatment Diabetic Retinopathy Study scale (ETDRS), Diabetes Complications Severity Index (DCSI), or CV-scores) and ischemic heart disease (IHD: death, silent/nonfatal myocardial infarct, revascularization, or confirmed angina) were analyzed.</p> <p>RESULTS</p> <p>Without interactions, in the minimal adjusted model controlling for confounding bias by age and HbA1c, SH was a significant IHD factor (p~0.003). SH remained a significant factor for IHD in fully adjusted models (p<0.05). In models with interactions, interactions between SH and surrogates of microvascular complications severity, but not between SH and CV-score, were significant. Hazard ratios for IHD based on SH increased 1.19-fold, 1.32-fold, and 2.21-fold for each additional year of diabetes duration, ETDRS-unit, and DCSI-unit, respectively. At time of IHD event, ~15% of 110 participants with SH had high CV-scores.</p> <p> </p> <p>CONCLUSION</p> <p>In a young T1D cohort with no baseline macrovascular complications, surrogates of baseline microvascular damage severity impact the effect of SH on IHD. Older age with high CV-score per se is not mandatory for an association of SH with IHD. However, the association is multifactorial.</p>

scholarly journals Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ruchi Jain ◽  
Türküler Özgümüş ◽  
Troels Mygind Jensen ◽  
Elsa du Plessis ◽  
Magdalena Keindl ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Vascular Complications ◽  
Nucleotide Biosynthesis ◽  
Term Type

Autoimmune comorbidity and microvascular complications in childhood-onset type 1 diabetes after 20 years of diabetes duration. A questionnaire study

2012 ◽  
Vol 153 (6) ◽  
pp. 222-226
Author(s):  
Katalin H. Nagy ◽  
Barnabás Rózsai ◽  
Kálmán Kürti ◽  
Ilona Rippl ◽  
Éva Erhardt ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Microvascular Complications ◽  
Thyroid Autoimmunity ◽  
Vascular Complications ◽  
Population Based ◽  
Diabetes Duration ◽  
Childhood Onset ◽  
Onset Type

There are no population-based data on the autoimmune morbidity and vascular complications of young adults with childhood-onset type 1 diabetes in Hungary. Aims: To assess the prevalence of these morbidities after 20 years of diabetes duration. Method: Postal questionnaire. Results: 6.2% of the patients had celiac disease. Diabetes was diagnosed at a significantly earlier age in patients with diabetes and celiac disease as compared to those without celiac diasease. Thyroid autoimmunity was reported in 7.6% of cases. They were significantly older with longer duration of diabetes. Every fifth patients reported retinopathy, one sixth of patients was treated for hypertension. Neuropathy was found in 3.4% and kidney disease in 4.8% of the cases. Conclusions: Apart from retinopathy and hypertension, the prevalence of microvascular complications was relatively low. Considering the limitations of questionnaire studies, laboratory screening is warranted to assess the true prevalence of comorbidities and complications. Orv. Hetil., 2012, 153, 222–226.

scholarly journals Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study

2021 ◽  
Author(s):  
Elke R. Fahrmann ◽  
Laura Adkins ◽  
Henry K. Driscoll
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Severe Hypoglycemia ◽  
Vascular Damage ◽  
Diabetes Duration ◽  
Ischemic Heart

OBJECTIVE <p>Literature suggests that severe hypoglycemia (SH) may be linked to cardiovascular events only in older individuals with high cardiovascular risk score (CV-score). Whether a potential relationship between any-SH and cardiovascular disease exists and whether it is conditional on vascular damage severity in a young type 1 diabetes (T1D) cohort without apparent macro-vascular and no or mild-to-moderate micro-vascular complications at baseline is unknown.</p> <p>RESEARCH DESIGN AND METHODS</p> <p>We evaluated data of 1441 Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) volunteers (diabetes duration 1-15 years) followed for ~30 years. Time-dependent associations between any-SH, interactions of any-SH with surrogates of baseline micro-/macro- vascular damage severity (diabetes duration, Early Treatment Diabetic Retinopathy Study scale (ETDRS), Diabetes Complications Severity Index (DCSI), or CV-scores) and ischemic heart disease (IHD: death, silent/nonfatal myocardial infarct, revascularization, or confirmed angina) were analyzed.</p> <p>RESULTS</p> <p>Without interactions, in the minimal adjusted model controlling for confounding bias by age and HbA1c, SH was a significant IHD factor (p~0.003). SH remained a significant factor for IHD in fully adjusted models (p<0.05). In models with interactions, interactions between SH and surrogates of microvascular complications severity, but not between SH and CV-score, were significant. Hazard ratios for IHD based on SH increased 1.19-fold, 1.32-fold, and 2.21-fold for each additional year of diabetes duration, ETDRS-unit, and DCSI-unit, respectively. At time of IHD event, ~15% of 110 participants with SH had high CV-scores.</p> <p> </p> <p>CONCLUSION</p> <p>In a young T1D cohort with no baseline macrovascular complications, surrogates of baseline microvascular damage severity impact the effect of SH on IHD. Older age with high CV-score per se is not mandatory for an association of SH with IHD. However, the association is multifactorial.</p>

Evaluation of gastric emptying and neuropathy in short- and long-term type-1 diabetes

2006 ◽  
Vol 44 (05) ◽  
Author(s):  
T Várkonyi ◽  
É Börcsök ◽  
R Takács ◽  
R Róka ◽  
C Lengyel ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gastric Emptying ◽  
Short And Long Term ◽  
Term Type

scholarly journals MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes

Diabetologia ◽  
2021 ◽  
Author(s):  
Isabelle Nel ◽  
Lucie Beaudoin ◽  
Zouriatou Gouda ◽  
Camille Rousseau ◽  
Pauline Soulard ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Recent Onset ◽  
Cell Alterations ◽  
Term Type ◽  
Mait Cell
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