Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort

AbstractIn this cohort study, we assessed the association between depression and the risk of Alzheimer’s disease from data obtained from the 2002 to 2013 Korean National Health Insurance Service-Elderly Cohort Database, which accounts for 10% of the South Korean population aged > 60 years. A total 518,466 patients were included in the analysis and followed up, unless they were excluded due to death or migration. Patients who sought treatment for depression or dementia within 1 year of the washout period and who were diagnosed with dementia within the 1-year period of the diagnosis of depression were excluded from the study. The risk of dementia was analysed using Cox proportional hazards models. Patients with a history of depression during the follow-up period were at a higher risk of Alzheimer’s disease than those without a history of depression (HR 3.35, CI 3.27–3.42). The severe-depression group exhibited the highest risk of Alzheimer’s disease (HR 4.41, CI 4.04–4.81), while the mild-depression group exhibited a relatively lower risk of Alzheimer’s disease (HR 3.31, CI 3.16–3.47). The risk of Alzheimer’s disease was associated with depression history and an increased severity of depression increased the risk of Alzheimer’s disease.

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Survival Analysis of Patients with Alzheimer’s Disease: A Study Based on Data from the Korean National Health Insurance Services’ Senior Cohort Database

Korean Journal of Family Medicine ◽

10.4082/kjfm.18.0114 ◽

2020 ◽

Vol 41 (4) ◽

pp. 214-221

Author(s):

Tae Ho Huh ◽

Jong Lull Yoon ◽

Jung Jin Cho ◽

Mee Young Kim ◽

Young Soo Ju

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Survival Analysis ◽

Health Insurance ◽

National Health Insurance ◽

National Health ◽

Korean National Health Insurance

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Different Effects of Metabolic Syndrome on Dementia According to Dementia Type: Analysis Based on the National Health Insurance Service Database of Gangwon Province in South Korea

10.21203/rs.3.rs-35451/v1 ◽

2020 ◽

Author(s):

YEO JIN KIM ◽

Sang Mi Kim ◽

Dae Hyun Jeong ◽

Sang-Kyu Lee ◽

Moo-Eob Ahn ◽

...

Keyword(s):

Metabolic Syndrome ◽

Health Insurance ◽

National Health Insurance ◽

National Health ◽

International Classification Of Disease ◽

History Of ◽

Korean National Health Insurance ◽

High Glucose Level ◽

The Relationship

Abstract BackgroundMetabolic syndrome is a cluster of conditions that occur together, increasing the risk of cardiovascular disease. However, the relationshipbetween metabolic syndrome and dementia has remained controversial. Using nationwide population cohort data, we investigated the associationbetween metabolic syndrome and dementia,according to the dementia type.MethodsWe analyzed data of 84,144 individuals,in the aged group of more than 60 years,between January 1, 2009,to December 31, 2009, at Gangwon province by using the information of the(Korean) National Health Insurance Service. After eight years of gap, in 2017, we investigated the relationship between metabolic syndrome and dementia. We classified Dementia either as dementia of the Alzheimer type (AD) or vascular dementia (VD). AD and VD were defined according to criteria in the International Classification of Disease, Tenth Revision, Clinical Modification codes.ResultsMetabolic syndrome was associated with AD, while it was not associated with VD. All five components of metabolic syndrome were associated with AD, independently. However, among components of metabolic syndrome, only the high glucose level was associated with VD. Body Mass Index (BMI), fasting glucose and smoking were also associated with AD. A history of the previous stroke was associated with both AD and VD.ConclusionsMetabolic syndrome was associated with AD, while was not associated with VD. VD was associated only with several risk factors that could affect the vascular state rather than a metabolic syndrome. We suggested that the effect of metabolic syndrome on dementia would be different depending on the type of dementia.

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