scholarly journals Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Evania Astella Setiawan ◽  
Davrina Rianda ◽  
Muzal Kadim ◽  
Meilianawati ◽  
Fenny Susanto ◽  
...  
Keyword(s):  
Maternal Education ◽  
Family Income ◽  
Lactobacillus Reuteri ◽  
Calcium Supplementation ◽  
Female Adolescents ◽  
Z Score ◽  
Long Term Effects ◽  
Clinical Trial Registration ◽  
Link Type

AbstractMicrobiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents.Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289.

scholarly journals Factors Associated with the Nutritional Status of Toddlers at the Limo Community Health Center, Depok City, Indonesia

2021 ◽  
Vol 13 (2) ◽  
pp. 701-706
Author(s):  
Munaya Fauziah ◽  
Tria Astika Endah Permatasari ◽  
Dadang Herdiansyah ◽  
Noor Latifah ◽  
Ma’mun Murod Albarbasy ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Community Health ◽  
Health Center ◽  
Maternal Education ◽  
Family Income ◽  
Community Health Center ◽  
Z Score ◽  
Children Under Five ◽  
Under Five ◽  
Nutritional Status Of Children

Undernutrition in urban areas remains a serious public health problem in Indonesia. The study aimed to find out what factors were related to the nutritional status of children under five in the working area of the Limo Community Health Center, Limo District. Depok City, Indonesia in 2019. This research was conducted in June-July 2019 using a cross-sectional study design with a sample of 118 mothers who have toddlers aged 6-59 months in the Limo Health Center work area in 2019. The sampling technique used simple random sampling. The analysis was performed using chi-square (α = 0.05). Undernutrition is defined as the condition of children under five which is determined based on the anthropometric index measurement results of body weight for age with a Z- score of -2 SD to ≤ -3 SD, while good nutrition is at a Z-score of -2 SD to 2 SD. As a result, the prevalence of undernutrition was 16.1%. As much as 50% of the respondents had high school education and mothers with low education were 32.2%. The results showed a prevalence of working mothers (13.6%), family income < Rp. 4,600,000 (52.5%), mothers with low knowledge (25.4%), male children (53.4%), poor parenting (3.4%), and mothers who did not use health services properly (3.4%). There was a significant relationship between maternal education (p = 0.004; OR: 4,813; 95% CI: 1,711-13,537), family income (p = 0.006; OR: 6.145; 95% CI: 1.68-22.43), and maternal knowledge (p = 0.007; OR: 4.389; 95% CI: 1.57-12.23) with the nutritional status of children under five in the working area of the Limo Community Health Center. The suggestion is that the Limo Community Health Center make a program to increase the knowledge capacity of mothers regarding the nutrition of their children.

Long-Term Effects of Calcium Supplementation on Bone Loss and Fractures in Postmenopausal Women

1995 ◽  
Vol 50 (10) ◽  
pp. 733-735 ◽  
Author(s):  
Ian R. Reid ◽  
Ruth W. Ames ◽  
Margaret C. Evans ◽  
Gregory D. Gamble ◽  
Susan J. Sharpe
Keyword(s):  
Bone Loss ◽  
Postmenopausal Women ◽  
Calcium Supplementation ◽  
Long Term Effects

scholarly journals Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study

2013 ◽  
Vol 98 (3) ◽  
pp. 723-730 ◽  
Author(s):  
Landing MA Jarjou ◽  
Yankuba Sawo ◽  
Gail R Goldberg ◽  
M Ann Laskey ◽  
Tim J Cole ◽  
...  
Keyword(s):  
Calcium Intake ◽  
Calcium Supplementation ◽  
Long Term Effects ◽  
Follow Up Study ◽  
Low Calcium ◽  
In Pregnancy

066 Impact of long-term teriflunomide treatment on lymphocyte counts and infections in pooled temso and tower studies

2018 ◽  
Vol 89 (6) ◽  
pp. A27.1-A27
Author(s):  
Giancarlo Comi ◽  
Richard Macdonell ◽  
Myriam Benamor ◽  
Philippe Truffinet ◽  
Karthinathan Thangavelu ◽  
...  
Keyword(s):  
Treated Patient ◽  
Low Grade ◽  
Long Term Effects ◽  
Pooled Data ◽  
Link Type ◽  
Serious Infection ◽  
Serious Infections ◽  
Placebo Treated Patient ◽  
Grade 3

IntroductionIn TEMSO (NCT00134563) and TOWER (NCT00751881), teriflunomide was associated with early reductions in mean lymphocyte counts, which remained within the normal range. Here, we analyse long-term effects of teriflunomide on lymphocyte counts and infections in pooled TEMSO/TOWER core and extension data (TEMSO extension, NCT00803049).MethodsPooled data from core studies are reported for patients receiving placebo or teriflunomide 14 mg. In the extensions, placebo-treated patients received active treatment; results from pooled core and extension studies are reported for the teriflunomide 14 mg group. Lymphocyte counts were obtained every 2 weeks until Week 24, and every 6 weeks thereafter. Lymphopenia was identified from 2 consecutive lymphocyte counts below LLN and graded by Common Terminology Criteria for Adverse Events.ResultsIn the core studies, placebo/teriflunomide-treated patients rarely experienced Grade 1 (0.7%/2.1%) or 2 (0.5%/1.4%) lymphopenia. Infections were reported in placebo-treated (40.0%/75.0%) and teriflunomide-treated (73.3%/20.0%) patients with Grade 1 or 2 lymphopenia, respectively. No patients with Grade 1 lymphopenia and 1 placebo-treated patient with Grade 2 lymphopenia developed a serious infection. In the combined core and extension studies, teriflunomide-treated patients (n=1354) experienced few Grade 1 (3.0%) or 2 (2.4%) lymphopenias; infections were reported in 25/40 (62.5%) and 19/33 (57.6%) patients, respectively, vs 718/1281 (56.0%) patients without lymphopenia. Serious infections occurred in patients without lymphopenia (47 patients [3.7%]) and in those with Grade 1 (1 [2.5%]) or Grade 2 (3 [9.1%]) lymphopenia. No Grade 3/4 lymphopenias were recorded. Despite the overall low rate of lymphopenia, occurrence and severity of lymphopenia will also be reported in subgroups of Asian and white patients.ConclusionIn long-term TEMSO and TOWER trials, low-grade lymphopenia was uncommon, with no reports of high-grade lymphopenia. Infection rates were similar in patients with or without lymphopenia, consistent with an immunomodulatory mechanism of action of teriflunomide with limited impact on protective immunity.

Sign in / Sign up

Export Citation Format

Share Document