scholarly journals The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fei Li ◽  
AiQin Niu ◽  
XingMei Feng ◽  
Ying Yan ◽  
Ying Chen
Keyword(s):  
Spontaneous Abortion ◽  
Smooth Curve ◽  
Threshold Effect ◽  
Reproductive Technology ◽  
Effect Analysis ◽  
Female Age ◽  
Factors Associated ◽  
Curve Fit ◽  
Follicular Stimulating Hormone ◽  
Stimulating Hormone

AbstractWe explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated with human-assisted reproductive technology (ART) and established a smooth curve fit and perform a threshold effect analysis can provide guidance and a valuable reference for predicting the probability of spontaneous abortion. This was a retrospective cohort study of 16,097 patients successfully conceived with ART in Shangqiu First People's Hospital from June 2013 to December 2018. Overall, 2,378 (14.77%) had an abortion and 13,719 (85.23%) did not have an abortion. Multivariate logistic regression analysis showed that female age (OR 1.050; 95% CI 1.032–1.069; P < 0.001), male age (OR 1.100; 95% CI 1.086–1.115; P < 0.001), follicular-stimulating hormone (OR 1.049; 95% CI 1.022–1.076; P < 0.001), anti-Mullerian hormone (OR 0.893; 95% CI 0.862–0.925; P < 0.001) and the number of fetuses at pregnancy diagnosis were independent factors associated with spontaneous abortion. The threshold effect analysis found that when female age > 32 years (cut-off point) old, age and the risk of spontaneous abortion were positively correlated. When follicular-stimulating hormone > 6.1 IU/L (cut-off point), follicular-stimulating hormone was positively correlated with the occurrence of spontaneous abortion, When anti-Mullerian hormone ≤ 3.1 ng/mL (cut-off point), anti-Mullerian hormone was negatively correlated with the occurrence of spontaneous abortion and there was a linear positive correlation between antral Follicle Counting and live birth. In addition, the older the male age, the higher the incidence of abortion. The smooth curve fit and threshold effect analyses can provide a more detailed estimate of the probability of spontaneous abortion for pregnant couples.

scholarly journals Variability of the total ozone trend over Europe for the period 1950–2004 derived from reconstructed data

2008 ◽  
Vol 8 (11) ◽  
pp. 2847-2857 ◽  
Author(s):  
J. W. Krzyścin ◽  
J. L. Borkowski
Keyword(s):  
Total Ozone ◽  
A Priori ◽  
Smooth Curve ◽  
Ozone Level ◽  
Svalbard Archipelago ◽  
Small Areas ◽  
Ozone Data ◽  
Curve Fit ◽  
Long Term Changes

Abstract. The total ozone data over Europe are available for only few ground-based stations in the pre-satellite era disallowing examination of the spatial trend variability over the whole continent. A need of having gridded ozone data for a trend analysis and input to radiative transfer models stimulated a reconstruction of the daily ozone values since January 1950. Description of the reconstruction model and its validation were a subject of our previous paper. The data base used was built within the objectives of the COST action 726 "Long-term changes and climatology of UV radiation over Europe". Here we focus on trend analyses. The long-term variability of total ozone is discussed using results of a flexible trend model applied to the reconstructed total ozone data for the period 1950–2004. The trend pattern, which comprises both anthropogenic and "natural" component, is not a priori assumed but it comes from a smooth curve fit to the zonal monthly means and monthly grid values. The ozone long-term changes are calculated separately for cold (October–next year April) and warm (May–September) seasons. The confidence intervals for the estimated ozone changes are derived by the block bootstrapping. The statistically significant negative trends are found almost over the whole Europe only in the period 1985–1994. Negative trends up to −3% per decade appeared over small areas in earlier periods when the anthropogenic forcing on the ozone layer was weak . The statistically positive trends are found only during warm seasons 1995–2004 over Svalbard archipelago. The reduction of ozone level in 2004 relative to that before the satellite era is not dramatic, i.e., up to ~−5% and ~−3.5% in the cold and warm subperiod, respectively. Present ozone level is still depleted over many popular resorts in southern Europe and northern Africa. For high latitude regions the trend overturning could be inferred in last decade (1995–2004) as the ozone depleted areas are not found there in 2004 in spite of substantial ozone depletion in the period 1985–1994.

scholarly journals Demographic and Clinical Factors Associated With the Appropriate Target Thyroid-Stimulating Hormone Values in Patients With Primary Hypothyroidism Treated With Levothyroxine

2016 ◽  
Vol 6 (4) ◽  
pp. 109-115
Author(s):  
Lara Moreira Baptista de Sousa ◽  
Elisa Baranski Lamback ◽  
Thomaz Schroder Lameirinhas ◽  
Michelle Botelho Caarls ◽  
Leonardo Vieira Neto
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Clinical Factors ◽  
Factors Associated ◽  
Stimulating Hormone

scholarly journals Recombinant Follicular Stimulating Hormone Plus Recombinant Luteinizing Hormone Versus Human Menopausal Gonadotropins- Does the Source of LH Bioactivity Affect Ovarian Stimulation Outcome?

2021 ◽  
Author(s):  
Michal Kirshenbaum ◽  
Or Gil ◽  
Jigal Haas ◽  
Ravit Nahum ◽  
Eran Zilberberg ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Stimulation ◽  
Intracellular Signaling ◽  
Physiological Role ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Common Receptor ◽  
The Mean ◽  
Follicular Stimulating Hormone ◽  
Stimulating Hormone

Abstract Background: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) activate distinct intracellular signaling cascades. However, due to their similar structure and common receptor, they are used interchangeably during ovarian stimulation (OS). This study aims to assess if the source of LH used during OS affects IVF outcome. Materials and methods: This was a cross sectional study of patients who underwent two consecutive IVF cycles, one included recombinant follicular stimulating hormone (FSH) plus recombinant LH [rFSH+rLH, (Pergoveris)] and the other included urinary hCG [highly purified hMG (HP-hMG), (Menopur)]. The OS protocol, except of the LH preparation, was identical in the two IVF cycles. Results: The rate of mature oocytes was not different between the treatment cycles (0.9 in the rFSH+rLH vs 0.8 in the HP-hMG, p=0.07). Nonetheless, the mean number of mature oocytes retrieved in the rFSH+rLH treatment cycles was higher compared to the HP-hMG treatment cycles (10 ± 5.8 vs 8.3 ±4.6, respectively, P=0.01). Likewise, the mean number of fertilized oocytes was higher in the rFSH+rLH cycles compared with the HP-hMG cycles (8.5 ± 5.9 vs 6.4 ± 3.6, respectively, p=0.05). There was no difference between the treatment cycles regarding the number of top-quality embryos, the ratio of top-quality embryos per number of oocytes retrieved or fertilized oocytes or the pregnancy rate. Conclusion: The differences in treatment outcome, derived by different LH preparations reflect the distinct physiological role of these molecules. Our findings may assist in tailoring a specific GT regimen when assembling an OS protocol.

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