scholarly journals Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hahn Jin Jung ◽  
Young-Kyung Ko ◽  
Woo Sub Shim ◽  
Hyun Jik Kim ◽  
Dong-Young Kim ◽  
...  
Keyword(s):  
Nasal Mucosa ◽  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Allergic Symptom ◽  
Eosinophil Infiltration ◽  
Dust Mite ◽  
Symptom Scores ◽  
Exhaust Particles

AbstractDiesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear. Therefore, this study aimed to investigate the effect of DEP exposure on AR using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP. Allergic symptom scores, serum total and HDM-specific immunoglobulins (Igs), eosinophil infiltration in the nasal mucosa, cytological profiles in bronchoalveolar lavage fluid (BALF), and cytokine levels in the nasal mucosa and spleen cell culture were analyzed. Mice co-exposed to HDM and DEP showed increased allergic symptom scores compared with mice exposed to HDM alone. Reduced total IgE and HDM-specific IgE and IgG1 levels, decreased eosinophil infiltration in the nasal mucosa, and increased proportion of neutrophils in BALF were found in mice co-exposed to HDM and DEP. Interleukin (IL)-17A level was found to be increased in the nasal mucosa of the co-exposure group compared with that in the HDM-exposed group. The levels of IL-4, IL-13, interferon-γ, IL-25, IL-33, and TSLP expression showed no difference between the groups with and without DEP treatment. Increased expression of IL-17A in the nasal mucosa may contribute to DEP-mediated exacerbation of AR in HDM-sensitized murine AR model.

scholarly journals Effect of Diesel Exhaust Particles on House Dust Mite–Induced Airway Eosinophilic Inflammation and Remodeling in Mice

2010 ◽  
Vol 112 (2) ◽  
pp. 192-202 ◽  
Author(s):  
Go Takahashi ◽  
Hiroyuki Tanaka ◽  
Keiko Wakahara ◽  
Reishi Nasu ◽  
Mikiko Hashimoto ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Eosinophilic Inflammation ◽  
Dust Mite ◽  
Exhaust Particles

scholarly journals Diesel Exhaust Particles Induce Cysteine Oxidation and S-Glutathionylation in House Dust Mite Induced Murine Asthma

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e60632 ◽  
Author(s):  
Gerald B. Lee ◽  
Eric B. Brandt ◽  
Chang Xiao ◽  
Aaron M. Gibson ◽  
Timothy D. Le Cras ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Cysteine Oxidation ◽  
Dust Mite ◽  
Exhaust Particles

Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis

2017 ◽  
Vol 131 (11) ◽  
pp. 997-1001 ◽  
Author(s):  
E Sahin ◽  
D Dizdar ◽  
M E Dinc ◽  
A A Cirik
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Specific Immunotherapy ◽  
Subcutaneous Immunotherapy ◽  
Long Term Effects ◽  
Allergen Specific Immunotherapy ◽  
Dust Mite ◽  
Symptom Scores

AbstractBackground:Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis.Methods:The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients).Results:The symptom scores before allergen-specific immunotherapy were significantly higher than those obtained after 3 years of allergen-specific immunotherapy and 10 years after allergen-specific immunotherapy (p < 0.0175). There were no significant differences between the scores obtained at 3 years and 10 years after allergen-specific immunotherapy (p > 0.0175).Conclusion:Subcutaneous immunotherapy is an effective treatment for house dust mite induced allergic rhinitis.

Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period

2016 ◽  
Vol 130 (3) ◽  
pp. 272-277 ◽  
Author(s):  
J Y Soh ◽  
M Thalayasingam ◽  
S Ong ◽  
E X L Loo ◽  
L P Shek ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Nasal Symptom ◽  
Medication Usage ◽  
Dust Mite ◽  
Symptom Scores

AbstractBackground:Sublingual immunotherapy in patients with allergic rhinitis sensitised to house dust mites is safe, but its efficacy is controversial and sublingual immunotherapy withBlomia tropicalishas not yet been studied. This study sought to evaluate the efficacy of sublingual immunotherapy with house dust mite extract in children and adults with house dust mite allergic rhinitis over a period of two years.Methods:A prospective observational study was conducted of children and adults diagnosed with house dust mite allergic rhinitis who were treated with sublingual immunotherapy from 2008 to 2012. Total Nasal Symptom Scores, Mini Rhinoconjunctivitis Quality of Life scores and medication usage scores were assessed prospectively.Results:Thirty-nine patients, comprising 24 children and 15 adults, were studied. Total Nasal Symptom Scores and Mini Rhinoconjunctivitis Quality of Life scores dropped significantly at three months into therapy, and continued to improve. Medication usage scores improved at one year into immunotherapy.Conclusion:Sublingual immunotherapy with house dust mite extracts, includingB tropicalis, is efficacious as a treatment for patients with house dust mite allergic rhinitis.

scholarly journals Diesel exhaust and house dust mite allergen lead to common changes in the airway methylome and hydroxymethylome

2018 ◽  
Vol 4 (3) ◽  
Author(s):  
Xue Zhang ◽  
Xiaoting Chen ◽  
Matthew T Weirauch ◽  
Xiang Zhang ◽  
J D Burleson ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Mite Allergen ◽  
House Dust Mite Allergen ◽  
Dust Mite ◽  
Dust Mite Allergen

Differences in airway-inflammation development by house dust mite and diesel exhaust inhalation among mouse strains

2003 ◽  
Vol 187 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Takamichi Ichinose ◽  
Hirohisa Takano ◽  
Kaori Sadakane ◽  
Rie Yanagisawa ◽  
Hiroaki Kawazato ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Mouse Strains ◽  
Dust Mite
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