scholarly journals Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Srinivasan Sanjay ◽  
Santosh Gopi Krishna Gadde ◽  
Sameeksha Agrawal ◽  
Padmamalini Mahendradas ◽  
Nivedhitha Govindaswamy ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Analysis ◽  
Febrile Illness ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Qualitative And Quantitative Analysis ◽  
Fundus Fluorescein Angiography ◽  
Qualitative And Quantitative ◽  
Capillary Rarefaction ◽  
Retinal Microvasculature

AbstractPost fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alternative to fundus fluorescein angiography to image the retinal microvasculature. We hereby describe the vascular changes during the acute phase of post fever retinitis on OCTA. Imaging on OCTA was done for all patients with post fever retinitis at presentation with 3 × 3 mm and 8 × 8 mm scans centred on the macula and corresponding enface optical coherence tomography (OCT) scans obtained. A qualitative and quantitative analysis was done for all images. 46 eyes of 33 patients were included in the study. Salient features noted were changes in the superficial (SCP) and deep capillary plexus (DCP) with capillary rarefaction and irregularity of larger vessels in the SCP. The DCP had more capillary rarefaction when compared to the SCP. The foveal avascular zone (FAZ) was altered with an irregular perifoveal network. Our series of post fever retinitis describes the salient vascular features on OCTA. Although the presumed aetiology was different in all our patients, they developed similar changes on OCTA. While OCTA is not useful if there is gross macular oedema, the altered FAZ can be indicative of macular ischemia.

scholarly journals Assessment of Macular Capillary Perfusion by Optical Coherence Tomography Angiography on Quiescent Unilateral Anterior Pediatric Uveitis

2021 ◽  
Author(s):  
Junyan Xiao ◽  
Yi Qu ◽  
Chan Zhao ◽  
Hang Song ◽  
Anyi Liang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Flow Density ◽  
Vascular Density ◽  
Optical Coherence ◽  
Pediatric Uveitis ◽  
Retinal Microvasculature ◽  
Capillary Plexus ◽  
Fellow Eyes

Abstract Purpose: Using spectral domain optical coherence tomography angiography (SD-OCTA) to evaluate tomographic and microvascular parameters in the macula in quiescent unilateral anterior pediatric uveitis (APU) patients.Methods: Forty-two eyes of 21 patients diagnosed with unilateral APU and 21 eyes of 21 normal controls (NC) were included in this study. 6*6 mm macular scanning mode of SD-OCTA was used for all subjects. The central macular thickness (CMT), subfoveal choroidal thickness (SFCT), vascular density (VD) of superficial capillary plexus (SCP) and the deep capillary plexus (DCP), the foveal avascular zone (FAZ) area, and choriocapillary flow density (CFD) were analyzed and compared among affected, fellow, and NC eyes. Correlation analysis were used to evaluate the potential correlating factors with CFD.Results: DCP VD and CFD were significantly lower in quiescent affected eyes as compared to fellow and NCs eyes (DCP VD both p<0.001; CDF1.0: p=0.012 and p=0.003; CDF1.5: p=0.015 and p=0.006; CDF3.0: p=0.036 and p=0.010, respectively). SCP VD, DCP VD and CMT were significantly lower in the fellow eyes as compared to NC eyes (p=0.021; p<0.001; p=0.037, respectively); CFD was negatively correlated with FAZ and CMT in affected eyes and fellow eyes. No significant differences were detected in FAZ among the 3 groups (p > .05).Conclusions: As compared to NC eyes, both retinal and choroidal microvasculature were impaired in eyes with quiescent APU; retinal microvasculature in unaffected fellow eyes of unilateral APU was also impaired. OCTA is a useful technology for detection of subclinical microvascular changes in APU and may be useful as an additional prognostic tool.

scholarly journals Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age

2020 ◽  
Vol 9 (3) ◽  
pp. 883 ◽  
Author(s):  
Seung Hun Park ◽  
Heeyoon Cho ◽  
Sun Jin Hwang ◽  
Beomseo Jeon ◽  
Mincheol Seong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Foveal Avascular Zone ◽  
Vascular Density ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Age Related ◽  
Retinal Microvasculature ◽  
Significant Difference

In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 years of age; G4, age 60 years or older). All subjects underwent swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). The vascular density (VD) of the superficial (SCP) and deep capillary plexus (DCP), and choriocapillaris (CCP) were measured using OCTA. The vascular density of each capillary layer, foveal avascular zone (FAZ) area, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), and choroidal thickness (CT) were compared between age groups. Most OCT variables were correlated with OCTA variables. The FAZ area; VD of the SCP, DCP, and CCP; GC-IPL thickness; RT; and CT showed significant difference (p < 0.001) between G1 + G2 and G3 + G4, except for central GC-IPL thickness (p = 0.14) and central RT (p = 0.25). Density of the retinal capillary vasculature reduced and FAZ area increased after age 40, which represents the onset of middle age.

scholarly journals Microvascular Changes In The Recurrent Cystoid Macular Edema Secondary to Posterior Noninfectious Uveitis on Optical Coherence Tomography Angiography

2021 ◽  
Author(s):  
Valeria Albano ◽  
Silvana Guerriero ◽  
Claudio Furino ◽  
Giancarlo Sborgia ◽  
Alessandra Sborgia ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Cystoid Macular Edema ◽  
Optical Coherence Tomography Angiography ◽  
Posterior Uveitis ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Microvascular Changes ◽  
Capillary Rarefaction ◽  
Deep Layers

Abstract BACKGROUND: Posterior uveitis represents the second most frequent type of uveitis (15-30% of all uveitis). Non-infectious posterior uveitis complicated with secondary cystoid macular edema (CME) negatively affected the visual prognosis.The objective of the current study is to determine possible microvascular changes that can cause a relapsing uveitis-CME through optical coherence tomography angiography (OCTA).METHODS: This is a case-control study, an evaluation of patients with secondary CME noninfectious posterior uveitis-related undergoing dexamethasone (DEX) implant. The visits following the DEX-implant were carried out after 1 month, 2-months, 4-months, 6-months, and for up 1-year. A total of 76 eyes of 38 consecutive patients with noninfectious posterior uveitis were enrolled (consecutive sample). Complicated noninfectious posterior uveitis with secondary CME was diagnosed in 56 eyes of uveitis patients (24.3%) reviewed. RESULTS: Our investigation showed a reduction in superficial vessel plexus (SVP) measurements already within 2-month (84%), reaching 96.4% for up 1-year, however displaying an irregular profile in 69.6% of cases, persisting for up 1-year; the relapsing uveitis-CME eyes with irregular superficial foveal avascular zone (FAZ) profile were in 51%, while the SVP measurements reestablished in 100% of cases. Conversely, the deep vascular plexus (DVP) parameters restored occurred in a lower number of eyes within the 2-month (39.3%), remaining abnormal in 46.4% of cases for up 1-year; despite DVP restored in 53.6% of cases for up 1 year, a capillary rarefaction ring around the FAZ appeared in 80.4% of cases; the relapsing uveitis-CME eyes with abnormal DVP parameters were in 41% of cases, of which 92.1% showed a rarefaction ring had abnormal DVP.CONCLUSIONS: The use of OCTA allows to evaluate the retinal microvascular features, which could be the cause of the recurrence of CME in uveitis patients, despite the DEX-implant treatment. We suggested that the possibility of the recurrence of the uveitis-CME depends on the persistence of modifications of the superficial and deep layers, which we therefore consider appropriate to investigate. With this purpose it would be useful to introduce OCTA into the current imaging armamentarium in follow-up of patients with noninfectious uveitis-CME.

Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia

2021 ◽  
pp. bjophthalmol-2021-319540
Author(s):  
Jade Y. Moon ◽  
Itika Garg ◽  
Ying Cui ◽  
Raviv Katz ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Systemic Hypertension ◽  
Wide Field ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Capillary Plexus

Background/aimsPathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages of myopia with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA).MethodsThis prospective cross-sectional observational study included 186 eyes of 122 patients who had undergone imaging between November 2018 and October 2020. Vessel density (VD) and vessel skeletonised density (VSD) of superficial capillary plexus, deep capillary plexus and whole retina, as well as foveal avascular zone parameters, retinal thickness (RT) and choroidal thickness (CT), were calculated.ResultsThis study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (βVD=−0.39, βVSD=−10.25, p<0.01). HM was associated with decreased RT and CT. Reduction in RT was outside the macular region, while reduction in CT was in the macular region.ConclusionUsing WF SS-OCTA, we identified reduction in microvasculature and structural changes associated with myopia. Decrease in VD and VSD was greater in the temporal quadrant, and reductions in RT and CT were uneven across the retina. Further work may help identify risk factors for the progression of PM and associated vision-threatening complications.

scholarly journals Factors Affecting Repeatability of Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography in Healthy Subjects

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Taek Hoon Lee ◽  
Hyung Bin Lim ◽  
Ki Yup Nam ◽  
Kyeungmin Kim ◽  
Jung Yeul Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Signal Strength ◽  
Retinal Vessel ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Factors Affecting ◽  
Retinal Microvasculature ◽  
Retinal Vessel Density

Abstract Various factors can affect repeatability of optical coherence tomography angiography (OCTA) measurements, and they have not been studied sufficiently. We aimed to investigate the factors associated with the repeatability of automated superficial retinal vessel density (VD) and foveal avascular zone (FAZ) metrics acquired from OCTA. A total of 141 normal eyes from 141 healthy subjects were included, and two consecutive macular 6 × 6-mm angiography scans were performed. VD, perfusion density (PD), and FAZ of the superficial capillary plexus were calculated automatically. Reproducibility was assessed based on intraclass correlations (ICCs) and coefficients of variation (CVs). VD (ICC: 0.824, CV: 3.898) and PD (ICC: 0.845, CV: 4.042) over the entire 6-mm scan area showed better repeatability than VD (ICC: 0.752, CV: 17.470) and PD (ICC: 0.752, CV: 18.552) in the 1-mm scan, and with respect to the obtained FAZ metrics (ICC < 0.75, CV > 10.0%). Regression analyses showed that two factors, signal strength (p = 0.004) and average VD over the total 6-mm scan area (p < 0.001), were significantly correlated with the CV of the VD. Signal strength was associated with the repeatability of OCTA measurements and should be considered in the analysis of retinal VD and FAZ.

Sign in / Sign up

Export Citation Format

Share Document