scholarly journals Faecal occult blood screening and reduction of colorectal cancer mortality: a case-control study

1999 ◽  
Vol 79 (3-4) ◽  
pp. 680-683 ◽  
Author(s):  
J Faivre ◽  
M A Tazi ◽  
T El Mrini ◽  
C Lejeune ◽  
A M Benhamiche ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Mortality ◽  
Case Control Study ◽  
Occult Blood ◽  
Case Control ◽  
Faecal Occult Blood ◽  
Faecal Occult ◽  
Colorectal Cancer Mortality ◽  
Control Study ◽  
Blood Screening

scholarly journals Is colonoscopic surveillance reducing colorectal cancer mortality in ulcerative colitis? A population based case control study

Gut ◽  
1998 ◽  
Vol 42 (5) ◽  
pp. 711-714 ◽  
Author(s):  
P Karlén ◽  
D Kornfeld ◽  
O Broström ◽  
R Löfberg ◽  
P-G Persson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Confidence Interval ◽  
Cancer Mortality ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Colonoscopic Surveillance ◽  
Colorectal Cancer Mortality ◽  
Control Study

Background—Colonoscopic surveillance is a standard procedure in many patients with long standing, extensive ulcerative colitis (UC), in order to avoid death from colorectal cancer. No conclusive proof of its benefits has been presented however.Aims—To evaluate the association between colonoscopic surveillance and colorectal cancer mortality in patients with UC.Patients—A population based, nested case control study comprising 142 patients with a definite UC diagnosis, derived from a study population of 4664 patients with UC, was conducted.Methods—Colonoscopic surveillance in all patients with UC who had died from colorectal cancer after 1975 was compared with that in controls matched for age, sex, extent, and duration of the disease. Information on colonoscopic surveillance was obtained from the medical records.Results—Two of 40 patients with UC and 18 of 102 controls had undergone at least one surveillance colonoscopy (relative risk (RR) 0.29, 95% confidence interval 0.06 to 1.31). Twelve controls but only one patient with UC had undergone two or more surveillance colonoscopies (RR 0.22, 95% confidence interval 0.03 to 1.74), indicating a protective dose response relation.Conclusion—Colonoscopic surveillance may be associated with a decreased risk of death from colorectal cancer in patients with long standing UC.

Characteristics of Colorectal Cancer with False Negative Result on Immunochemical Faecal Occult Blood Test

1996 ◽  
Vol 3 (3) ◽  
pp. 115-118 ◽  
Author(s):  
Hidenori Nakama ◽  
Noboru Kamijo ◽  
Kazuya Fujimori ◽  
Akira Horiuchi ◽  
A S M Abdul Fattah ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Blood Test ◽  
Case Control Study ◽  
False Negative ◽  
Occult Blood ◽  
Faecal Occult Blood Test ◽  
Occult Blood Test ◽  
Faecal Occult Blood ◽  
Faecal Occult ◽  
Control Study

Objectives –A comparative study was carried out to clarify the clinicopathological features of colorectal cancer diagnosed after a false negative result on the immunochemical faecal occult blood test. Methods –236 patients with colorectal cancer were studied: 48 patients with negative results and 188 patients with positive results with the faecal occult blood test. The two groups were compared according to their age and sex and by the site, size, macroscopic type, Dukes's classification, and histological type of their cancer lesions. Additionally, the above factors were investigated prospectively and compared in 40 cases of colorectal cancer cases diagnosed as false negative and in matched cases diagnosed as true positive in cancer screening by the immunochemical faecal occult blood test. Results –In both the hospital based case-control study and the screening programme based nested case—control study the prevalence of rectal cancers was higher in the false negative group than in the true positive group (P = 0.02, P = 0.03), but there were no differences between the two groups for any other factors. Conclusion –These results suggest that the immunochemical faecal occult blood test is unsuitable for the diagnosis of rectal cancer.

scholarly journals Diagnostic Accuracy of Immunochemical Faecal Occult Blood Test for Gastric Cancer

1996 ◽  
Vol 3 (3) ◽  
pp. 113-114 ◽  
Author(s):  
Hidenori Nakama ◽  
Noboru Kamijo ◽  
Kazuya Fujimori ◽  
A S M Abdul Fattah ◽  
Bing Zhang
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Blood Test ◽  
Case Control Study ◽  
Occult Blood ◽  
Faecal Occult Blood Test ◽  
Occult Blood Test ◽  
Faecal Occult Blood ◽  
Faecal Occult ◽  
Control Study

Objectives –Toinvestigate the accuracy of the immunochemical occult blood test in screening for gastric cancer and to evaluate whether or not the upper digestive tract should be examined when the occult blood test is positive but there is no abnormal sign in the colorectum. Methods –In a case-control study an occult blood test was carried out on 150 subjects with gastric cancer, ISO subjects with colorectal cancer, and on 300 healthy subjects. Data were analysed from 44 996 persons attending a population screening programme who underwent both radiological gastric cancer screening (barium meal) and colorectal cancer examination by occult blood test. Results –In the case—control study the occult blood test was positive in 27/150 (18%) subjects with gastric cancer, in 112/150 (75%) subjects with colorectal cancer, and in 24/300 (8%) healthy controls. In the population screening programme the occult blood test was positive in 4/50 (8%) persons with gastric cancer and 3232/44 950 (7%) persons without gastric cancer,- indicating no difference between them. Conclusions –These data show that the immunochemical faecal occult blood test is worthless as a screening test for gastric cancer, and that examination of the upper digestive tract is unnecessary in cases where the faecal occult blood test is positive but there is no sign of colorectal disease.

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