scholarly journals Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo

Gene Therapy ◽  
2004 ◽  
Vol 11 (22) ◽  
pp. 1665-1672 ◽  
Author(s):  
A I Belenkov ◽  
V Y Alakhov ◽  
A V Kabanov ◽  
S V Vinogradov ◽  
L C Panasci ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Treatment Efficacy ◽  
Radiation Treatment ◽  
Pluronic P85

Fine Structural Changes in the Microvasculature of the Mouse Pinna: Aging and Radiation Injury

1974 ◽  
Vol 32 ◽  
pp. 54-55
Author(s):  
S. Phyllis Steamer ◽  
Rosemarie L. Devine
Keyword(s):  
Structural Changes ◽  
Radiation Treatment ◽  
Arterial Stenosis ◽  
Ultrastructural Changes ◽  
Vascular Effects ◽  
Microvascular Changes ◽  
Surrounding Connective Tissue ◽  
Fission Neutrons ◽  
Total Body

The importance of radiation damage to the skin and its vasculature was recognized by the early radiologists. In more recent studies, vascular effects were shown to involve the endothelium as well as the surrounding connective tissue. Microvascular changes in the mouse pinna were studied in vivo and recorded photographically over a period of 12-18 months. Radiation treatment at 110 days of age was total body exposure to either 240 rad fission neutrons or 855 rad 60Co gamma rays. After in vivo observations in control and irradiated mice, animals were sacrificed for examination of changes in vascular fine structure. Vessels were selected from regions of specific interest that had been identified on photomicrographs. Prominent ultrastructural changes can be attributed to aging as well as to radiation treatment. Of principal concern were determinations of ultrastructural changes associated with venous dilatations, segmental arterial stenosis and tortuosities of both veins and arteries, effects that had been identified on the basis of light microscopic observations. Tortuosities and irregularly dilated vein segments were related to both aging and radiation changes but arterial stenosis was observed only in irradiated animals.

scholarly journals Offset of apparent hyperpolarized 13 C lactate flux by the use of adjuvant metformin in ionizing radiation therapy in vivo

2021 ◽  
Author(s):  
Young‐Suk Choi ◽  
Joonsung Lee ◽  
Han‐Sol Lee ◽  
Jae Eun Song ◽  
Dong‐Hyun Kim ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Ionizing Radiation

scholarly journals Differential response of human glioblastoma cell lines to combined camptothecin and ionizing radiation treatment

2008 ◽  
Vol 7 (3) ◽  
pp. 364-373 ◽  
Author(s):  
Cholpon S. Djuzenova ◽  
Teresa Güttler ◽  
Sabrina Berger ◽  
Astrid Katzer ◽  
Michael Flentje
Keyword(s):  
Ionizing Radiation ◽  
Cell Lines ◽  
Radiation Treatment ◽  
Differential Response ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines

Implementation of an in vivo radiochromic film QA procedure

2016 ◽  
Author(s):  
◽  
Jason Stanford
Keyword(s):  
Quality Assurance ◽  
Radiation Treatment ◽  
Radiochromic Film ◽  
In Vivo Dosimetry ◽  
Patient Specific ◽  
Attractive Alternative ◽  
Quality Assurance Procedure ◽  
Imaging Device ◽  
Treatment Techniques

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Advance treatment techniques, such as IMRT and dynamic conformal arc delivery, are novel radiation treatment procedures at the forefront of accurate and precise radiotherapy. However, the risk of suboptimal treatment resulting in injury is far greater with these techniques due to their complexity. An in vivo quality assurance system is the most appropriate validation of the delivered dose to the patient from these techniques. The intent of this research is to propose an in vivo dosimetry quality assurance procedure using radiochromic film. This research proved that radiochromic in vivo dosimetry is a viable method of detecting spatial patient specific errors in radiotherapy; however, the process is time consuming and not sensitive enough for dosimetric errors associated with weight change. Although time consuming, in vivo radiochromic dosimetry is an attractive alternative for small cancer centers and developing countries without the large startup capital to acquire the electronic portal imaging device necessary for EPID in vivo dosimetry.

Anti-viral properties of interferon beta treatment in patients with multiple sclerosis

2002 ◽  
Vol 8 (3) ◽  
pp. 237-242 ◽  
Author(s):  
J Hong ◽  
M V Tejada-Simon ◽  
V M Rivera ◽  
Y CQ Zang ◽  
J Z Zhang
Keyword(s):  
Multiple Sclerosis ◽  
Treatment Efficacy ◽  
Interferon Beta ◽  
Viral Infections ◽  
Human Herpesvirus ◽  
Virion Protein ◽  
Cell Free Dna ◽  
Free Dna

Viral infections are potentially associated with the etiology and pathogenesis of multiple sclerosis (MS). It has been speculated that the treatment efficacy of interferon beta (IFN beta) in MS may relate to its anti-viral properties. The study was undertaken to evaluate the in vivo anti-viral effects of IFN beta-1a in patients with MS. Human herpesvirus-6 (HHV-6) was studied as an example for being a latent neurotropic virus. IFN beta used at concentrations of approximately 0.5 mg/ml was shown to significantly reduce in vitro HHV-6 replication in a susceptible T-cell line. Sera derived from 23 MS patients treated with IFN beta-1a were examined for serum cell-free DNA of HHV-6 as an indicator for viral replication and the reactivity of IgM antibodies to a recombinant HHV-6 virion protein containing a known immunoreactive region. The results were compared with those of control sera obtained from untreated MS (n=29) and healthy individuals (n=21). The findings indicated that IFN beta treatment significantly reduced HHV-6 replication as evident by decreased cell-free DNA in treated MS specimens. The results correlated with decreased IgM reactivity to the HHV-6 antigen in treated MS patients compared to untreated controls, suggesting reduced exposure to HHV-6. The findings were confirmed in paired sera obtained from seven MS patients before and after the treatment. The study provides new evidence indicating that IFN beta has potent in vivo anti-viral effects that may contribute to the treatment efficacy in MS.

scholarly journals In Vivo Study of the Efficacy and Safety of 5-Aminolevulinic Radiodynamic Therapy for Glioblastoma Fractionated Radiotherapy

2021 ◽  
Vol 22 (18) ◽  
pp. 9762
Author(s):  
Junko Takahashi ◽  
Shinsuke Nagasawa ◽  
Motomichi Doi ◽  
Masamichi Takahashi ◽  
Yoshitaka Narita ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Aminolevulinic Acid ◽  
Combined Treatment ◽  
Reactive Oxygen Species Generation ◽  
Photodynamic Diagnosis ◽  
High Dose ◽  
Severe Toxicity ◽  
Fractionated Radiotherapy ◽  
Post Surgery

To treat malignant glioma, standard fractionated radiotherapy (RT; 60 Gy/30 fractions over 6 weeks) was performed post-surgery in combination with temozolomide to improve overall survival. Malignant glioblastoma recurrence rate is extremely high, and most recurrent tumors originate from the excision cavity in the high-dose irradiation region. In our previous study, protoporphyrin IX physicochemically enhanced reactive oxygen species generation by ionizing radiation and combined treatment with 5-aminolevulinic acid (5-ALA) and ionizing radiation, while radiodynamic therapy (RDT) improved tumor growth suppression in vivo in a melanoma mouse model. We examined the effect of 5-ALA RDT on the standard fractionated RT protocol using U251MG- or U87MG-bearing mice. 5-ALA was orally administered at 60 or 120 mg/kg, 4 h prior to irradiation. In both models, combined treatment with 5-ALA slowed tumor progression and promoted regression compared to treatment with ionizing radiation alone. The standard fractionated RT protocol of 60 Gy in 30 fractions with oral administration of 120 and 240 mg/kg 5-ALA, the human equivalent dose of photodynamic diagnosis, revealed no significant increase in toxicity to normal skin or brain tissue compared to ionizing radiation alone. Thus, RDT is expected to enhance RT treatment of glioblastoma without severe toxicity under clinically feasible conditions.

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