scholarly journals Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects

2003 ◽  
Vol 27 (11) ◽  
pp. 1359-1364 ◽  
Author(s):  
P A Velasquez-Mieyer ◽  
P A Cowan ◽  
G E Umpierrez ◽  
R H Lustig ◽  
A K Cashion ◽  
...  



Metabolism ◽  
2014 ◽  
Vol 63 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Maria A. Sleddering ◽  
Leontine E.H. Bakker ◽  
Laura G.M. Janssen ◽  
A. Edo Meinders ◽  
Ingrid M. Jazet






2017 ◽  
Vol 6 (5) ◽  
pp. 151-158 ◽  
Author(s):  
Sylwia Płaczkowska ◽  
Izabela Kokot ◽  
Lilla Pawlik-Sobecka ◽  
Agnieszka Piwowar




2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria Fernanda Garcés ◽  
Julieth Daniela Buell-Acosta ◽  
Haiver Antonio Rodríguez-Navarro ◽  
Estefania Pulido-Sánchez ◽  
Juan José Rincon-Ramírez ◽  
...  

AbstractThis study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.



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