Quantitative evaluation of the neuroprotective effects of thiopental sodium, propofol and halothane on brain ischemia in gerbils: Use of a logistic regression curve

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S297-S297
Author(s):  
Motomu Kobayashi ◽  
Yoshimasa Takeda ◽  
Ken Takata ◽  
Hisami Aoe ◽  
Kiyoshi Morita
Keyword(s):  
Logistic Regression ◽  
Quantitative Evaluation ◽  
Brain Ischemia ◽  
Regression Curve ◽  
Neuroprotective Effects ◽  
Thiopental Sodium

Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases

2018 ◽  
Vol 19 (14) ◽  
pp. 1710-1720 ◽  
Author(s):  
Manish Putteeraj ◽  
Wei Ling Lim ◽  
Seong Lin Teoh ◽  
Mohamad Fairuz Yahaya
Keyword(s):  
Neurodegenerative Diseases ◽  
Brain Ischemia ◽  
Neuroprotective Effects

scholarly journals Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

Molecules ◽  
2015 ◽  
Vol 20 (8) ◽  
pp. 14487-14503 ◽  
Author(s):  
Denis Silachev ◽  
Egor Plotnikov ◽  
Ljubava Zorova ◽  
Irina Pevzner ◽  
Natalia Sumbatyan ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Brain Ischemia ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Neuroprotective Effects

Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of α-phenyl-N-tert-butyl nitrone

1998 ◽  
Vol 241 (2-3) ◽  
pp. 99-102 ◽  
Author(s):  
Hiroko Mori ◽  
Toshiyuki Arai ◽  
Hisanari Ishii ◽  
Takehiko Adachi ◽  
Nobuyuki Endo ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Neuroprotective Effects ◽  
Global Brain Ischemia ◽  
Tert Butyl ◽  
Global Brain

scholarly journals Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia

2020 ◽  
Vol 11 (3) ◽  
pp. 547 ◽  
Author(s):  
Yu Shimizu ◽  
Ai Harashima ◽  
Seiichi Munesue ◽  
Masahiro Oishi ◽  
Tsuyoshi Hattori ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Neuroprotective Effects ◽  
Glycation End Products ◽  
End Products

scholarly journals Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Shuai Yang ◽  
Bin Hu ◽  
Zongming Wang ◽  
Changming Zhang ◽  
Haosen Jiao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Brain Ischemia ◽  
Receptor Agonist ◽  
Ischemia Reperfusion Injury ◽  
Infarct Volume ◽  
Ischemia Reperfusion ◽  
Mitochondrial Fission ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Neuroprotective Effects

Abstract Activation of the cannabinoid CB1 receptor induces neuroprotection against brain ischemia/reperfusion injury (IRI); however, the mechanism is still unknown. In this study, we used oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in neuronal cells and middle cerebral artery occlusion (MCAO)-induced brain IRI in rats to mimic ischemic brain injury, and hypothesized that the CB1 receptor agonist arachidonyl-2-chloroethylamide (ACEA) would protect ischemic neurons by inhibiting mitochondrial fission via dynamin-related protein 1 (Drp1). We found that OGD/R injury reduced cell viability and mitochondrial function, increased lactate dehydrogenase (LDH) release, and increased cell apoptosis, and mitochondrial fission. Notably, ACEA significantly abolished the OGD/R-induced neuronal injuries described above. Similarly, ACEA significantly reversed MCAO-induced increases in brain infarct volume, neuronal apoptosis and mitochondrial fission, leading to the recovery of neurological functions. The neuroprotective effects of ACEA were obviously blocked by coadministration of the CB1 receptor antagonist AM251 or by the upregulation of Drp1 expression, indicating that ACEA alleviates brain IRI via the CB1–Drp1 pathway. Our findings suggest that the CB1 receptor links aberrant mitochondrial fission to brain IRI, providing a new therapeutic target for brain IRI treatment.

The Blockade of K+‐ATP Channels has Neuroprotective Effects in an In Vitro Model of Brain Ischemia

2007 ◽  
pp. 383-395 ◽  
Author(s):  
Robert Nisticò ◽  
Silvia Piccirilli ◽  
L. Sebastianelli ◽  
Giuseppe Nisticò ◽  
G. Bernardi ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
In Vitro Model ◽  
Neuroprotective Effects ◽  
Vitro Model
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