Predictors of sudden cardiac death in never previously treated patients with essential hypertension: long-term follow-up

Abstract Introduction Early repolarization syndrome is associated with long-term cardiac mortality in Western countries. However, there is no study of this association in Southeast Asian population. Purpose To determine the prevalence of early repolarization and long term risk of cardiac mortality in general Thai population. Methods A total of 2,756 consecutive individuals participating in from the electricity generating authority of Thailand (EGAT) study between 1997 and 2015 were included in this study. Early repolarization pattern (ERP) was defined either as “notching” or “slurring” and was localized into inferior leads, lateral leads, or both. Mortality endpoints included cardiovascular (CV) events and all-cause mortalities. Multivariable Cox-proportional hazard model, adjusted for all major CV risk factors, was used to determine the association between ERP and outcomes. Results Out of 2756 individuals,2,689 had complete data (80% male, mean age 55). ECGs and risk factor profiles were included for analysis. Mean follow up duration was 11.2±6.7 years. There were 444 (16.5%) cases with early repolarization pattern (slurr 54.3%, notching 38.3% and both 7.4%). Inferior leads were the most common localization at 49.8%, followed by lateral leads (35.6%) and both (14.6%). Five-hundred and sixty-six participants were dead during the follow-ups. Of these, 21 were sudden death. ERP was not associated with a greater likelihood of all causes of deaths, 20.5% in ERP and 21.2% in non-ERP (hazard ratio,1.04; 95% confidence interval (CI), 0.81 to 1.34; p=0.75). The death rates from coronary heart disease were 7.2% in ERP and 7.6% in non-ERP (HR,1.06; 95% CI, 0.71 to 1.56; p=0.79). The death rates from cardiovascular disease were 11.7% in ERP and 12.0% respectively (HR,1.03; 95% CI, 0.75 to 1.41; p=0.872) and sudden cardiac death was not difference between both groups 1.2 and 1.4% respectively. Conclusion The prevalence of early repolarization in Thai middle-aged population is relatively high. Over a long-term follow-up of 18 years, we did not find any differences in sudden cardiac death or death from any causes between an early repolarizationgroup and non-early repolarization group.

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Pump failure death and sudden cardiac death in patients with cardiac dysfunction: A search for prognostic predictive factors—A long-term follow-up study

Journal of Cardiology ◽

10.1016/j.jjcc.2009.08.005 ◽

2010 ◽

Vol 55 (1) ◽

pp. 55-64 ◽

Cited By ~ 7

Author(s):

Hiroki Usuku ◽

Masafumi Nakayama ◽

Hitoshi Sumida ◽

Megumi Yamamuro ◽

Yasuhiro Izumiya ◽

...

Keyword(s):

Sudden Cardiac Death ◽

Predictive Factors ◽

Cardiac Dysfunction ◽

Cardiac Death ◽

Pump Failure ◽

Follow Up Study ◽

Long Term Follow Up

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Early Repolarization Pattern Associated with Sudden Cardiac Death: Long-Term Follow-Up in Patients with Chronic Heart Failure

Journal of Cardiovascular Electrophysiology ◽

10.1111/jce.12093 ◽

2013 ◽

Vol 24 (6) ◽

pp. 632-639 ◽

Cited By ~ 20

Author(s):

YOSHIO FURUKAWA ◽

TAKAHISA YAMADA ◽

TAKASHI MORITA ◽

YUSUKE IWASAKI ◽

MASATO KAWASAKI ◽

...

Keyword(s):

Heart Failure ◽

Sudden Cardiac Death ◽

Chronic Heart Failure ◽

Cardiac Death ◽

Early Repolarization ◽

Long Term Follow Up

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Dual- vs. single-chamber defibrillators for primary prevention of sudden cardiac death: long-term follow-up of the Défibrillateur Automatique Implantable—Prévention Primaire registry

EP Europace ◽

10.1093/europace/euw230 ◽

2017 ◽

Vol 19 (9) ◽

pp. 1478-1484 ◽

Cited By ~ 21

Author(s):

Pascal Defaye ◽

Serge Boveda ◽

Didier Klug ◽

Frankie Beganton ◽

Olivier Piot ◽

...

Keyword(s):

Primary Prevention ◽

Sudden Cardiac Death ◽

Cardiac Death ◽

Prévention Primaire ◽

Single Chamber ◽

Long Term Follow Up

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Phase II Trial of Combination Intraperitoneal Cisplatin and 5-Fluorouracil in Previously Treated Patients with Advanced Ovarian Cancer: Long-Term Follow-up

Gynecologic Oncology ◽

10.1006/gyno.2000.5793 ◽

2000 ◽

Vol 77 (3) ◽

pp. 433-438 ◽

Cited By ~ 15

Author(s):

Robert J. Morgan ◽

Patricia Braly ◽

Lucille Leong ◽

Stephen Shibata ◽

Kim Margolin ◽

...

Keyword(s):

Ovarian Cancer ◽

Phase Ii ◽

Phase Ii Trial ◽

Advanced Ovarian Cancer ◽

Long Term Follow Up ◽

Previously Treated Patients ◽

Previously Treated

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Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study

Scientific Reports ◽

10.1038/s41598-021-95975-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Pang-Shuo Huang ◽

Jen-Fang Cheng ◽

Wen-Chin Ko ◽

Shu-Hsuan Chang ◽

Tin-Tse Lin ◽

...

Keyword(s):

Sudden Cardiac Death ◽

Cardiac Death ◽

Left Ventricular ◽

Asia Pacific ◽

Left Ventricular Ejection ◽

Arrhythmic Death ◽

Long Term Follow Up ◽

History Of

AbstractThere has been no long-term clinical follow-up data of survivors or victims of sudden cardiac death (SCD). The Taiwan multi-center sudden arrhythmia death syndrome follow-up and clinical study (TFS-SADS) is a collaborative multi-center study with median follow-up time 43 months. In this cohort, the clinical characteristics of these SADS patients were compared with those with ischemic heart disease (IHD). In this SCD cohort, around half (42%) were patients with IHD, which was different from Caucasian SCD cohorts. Among those with normal heart, most had Brugada syndrome (BrS). Compared to those with SADS, patients with IHD were older, more males and more comorbidities, more arrhythmic death, and lower left ventricular ejection fraction. In the long-term follow-up, patients with SADS had a better survival than those with IHD (p < 0.001). In the Cox regression analysis to identify the independent predictors of mortality, older age, lower LVEF, prior myocardial infarction and history of out-of-hospital cardiac arrest were associated with higher mortality and beta blocker use and idiopathic ventricular fibrillation or tachycardia (IVF/IVT) with a better survival during follow-up. History of prior MI was associated with more arrhythmic death. Several distinct features of SCD were found in the Asia–Pacific region, such as higher proportion of SADS, poorer prognosis of LQTS and better prognosis of IVF/IVT. Patients with SADS had a better survival than those with IHD. For those with SADS, patients with channelopathy had a better survival than those with cardiomyopathy.

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Bland-White-Garland syndrome in adults: sudden cardiac death as a first symptom and long-term follow-up after successful resuscitation and surgery

EP Europace ◽

10.1093/europace/euq087 ◽

2010 ◽

Vol 12 (9) ◽

pp. 1338-1340 ◽

Cited By ~ 16

Author(s):

P. Parizek ◽

L. Haman ◽

J. Harrer ◽

M. Tauchman ◽

V. Rozsival ◽

...

Keyword(s):

Sudden Cardiac Death ◽

Cardiac Death ◽

Successful Resuscitation ◽

Long Term Follow Up

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Pulsed Cyclophoshamide, Thalidomide and Dexamethasone (CTD) Regimen for Previously Treated Patients with Multiple Myeloma: Long Term Follow up and Disease Control after Subsequent Treatments.

Blood ◽

10.1182/blood.v108.11.3565.3565 ◽

2006 ◽

Vol 108 (11) ◽

pp. 3565-3565

Author(s):

Maria Roussou ◽

Athanasios Anagnostopoulos ◽

Efstathios Kastrtis ◽

Charis Matsouka ◽

Despina Barmparoussi ◽

...

Keyword(s):

Multiple Myeloma ◽

Partial Response ◽

Progression Free Survival ◽

Conventional Chemotherapy ◽

Free Survival ◽

Long Term Follow Up ◽

Previously Treated Patients ◽

Previously Treated

Abstract Introduction: The effectiveness of thalidomide based regimens in patients with relapsed/refractory multiple myeloma is well established. However, there is still limited data regarding the long term follow up after such regimens and the outcome of patients when they progress and they receive further treatment. In order to answer these questions we reassessed our original series of 43 patients with previously treated multiple myeloma who were treated with a pulsed, oral CTD regimen between December 2000 and April 2002 (Dimopoulos MA, Hematol J2004;5:112). The CTD regimen consisted of oral cyclophosphamide 150 mg/m2 every 12 hours before meals on days 1 to 5, thalidomide 400 mg p.o. in the evening on days 1 to 5 and 14 to 18 and dexamethasone 20 mg/m2 in the morning after breakfast on days 1 to 5 and 14 to 18. The CTD combination was repeated every 28 days for three courses. Subsequently, responding patients were scheduled to receive maintenance treatment with monthly courses of CTD administered only for the first five days of each month. Patients and Methods: Progression free survival after initiation of CTD was updated in June 2006,ie more than 4 years after inclusion of the last patient. Type of treatment at the time of progression after CTD, response to this treatment and progression free survival were recorded for each patient. Results: Among the 43 patients, 14 had not responded to CTD and 29 (67%) had achieved at least a partial response. The median PFS for all patients was 10 months. As of June 2006, 3 patients remain off treatment and without progression for 55+, 55+ and 56+ months respectively. Thus, 40 patients were analyzed for further treatment and outcome. Ten patients (25%) died before receiving further treatment, 9 patients(23%) received conventional chemotherapy and 21 patients (52%) received continuous thalidomide and dexamethasone(15 patients), melphalan-bortezomib-dexamethasone and intermittent thalidomide (3 patients) or lenalidomide with dexamethasone (3patients). Among the 21 latter patients,6(28%)achieved at least partial response. A response was documented in 31% of CTD-sensitive patients (ie patients who had responded to CTD and then progressed) and in 20% of CTD-resistant patients (ie patients who had not responded to CTD). The median progression free survival of the 21 patients who received retreatment with novel agents plus dexamethosone was 5,3 months and the median survival was 10 months. Among the 9 patients who received conventional chemotherapy only one patient responded and the progression free survival was 2,8 months. Conclusions: After an oral pulsed CTD regimen 7% of patients remain without treatment and free of progression for more than 4 years. Further control of myeloma was achieved in one-third of patients who progressed after CTD and who received further treatment which included a novel agent.

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