Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension

Abstract Introduction The evolving use of multiplex proteomic platforms provides an excellent tool for investigating associations between multiple proteins and subclinical atherosclerotic disease. In this study, we evaluated the impact of a multiplex protein panel, on carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis. Purpose We used a multiplex proteomic platform to identify possible associations between proteins and subclinical carotid atherosclerosis as measured by carotid ultrasound in an African population. Methods In the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study, 92 proteins from the Proseek Multiplex CVD III 96×96 (Olink Bioscience, Sweden) were analyzed in 378 participants (mean age 44.7±9.6 years, 50.6% women, 10.8% with known cardiovascular disease). Carotid ultrasound was performed for measurements of the carotid intima-media thickness (cIMT, mean 0.663±0.127 mm) and calculation of cross-sectional wall area (CSWA, mean 13.5±4.4mm2), a measure of target organ damage. Possible associations between the proteins, and cIMT and CSWA, respectively, were explored using linear regression models. A two-sided Bonferroni corrected P-value of 0.05/92=5.4x10–4 was considered statistically significant in the crude analysis. Results Of 18 proteins (1 standard deviation of change of ln-transformed values) that were Bonferroni-corrected (p≤5.4x10–4) significantly associated with cIMT and/or CWAS in crude analyses, the following remained significant after further adjustment for age, sex, waist circumference, systolic blood pressure, smoking and total cholesterol: growth-differentiation factor-15 (GDF15; β 0.017, p=0.050), E-selectin (SELE; β 0.019, p=0.017), carboxypeptidase A1 (CPA1; β 0.019, p=0.019), C-C motif chemokine 15 (CCL15; β 0.031, p<0.001), chitinase-3-like protein 1 (CHI3L1; β 0.021, p=0.007), the hemoglobin scavenger receptor (CD163; β 0.021, p=0.008) and osteoprotegerin (OPG; β 0.022, p=0.004). As for target-organ damage defined by CSWA, SELE (β 0.459, p=0.018), CCL15 (β 0.398; p=0.032) and CD163 (β 0.541, p=0.005) showed multivariate adjusted significant associations. Conclusion In an African population, we could confirm five proteins (GDF15, SELE, CHI3L1, CD163 and OPG) associated with cIMT, but in addition identified two proteins (CPA1 and CCL15) with novel associations with cIMT and/or CSWA. Acknowledgement/Funding North-West University; National Research Foundation (NRF); Medical Research Council (MRC-SA); Department of Education North-West Province; ROCHE

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Application of the Measurement of Carotid Intima-Media Thickness for Prediction of the Essential Hypertension in Children

Revista de Chimie ◽

10.37358/rc.18.6.6366 ◽

2018 ◽

Vol 69 (6) ◽

pp. 1550-1553

Author(s):

Rosana Manea ◽

Bianca Elena Popovici ◽

Carmen Daniela Neculoiu ◽

Dan Minea ◽

Alina Calin

Keyword(s):

Blood Pressure ◽

Essential Hypertension ◽

Carotid Artery ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Diagnostic Methods ◽

Control Group ◽

Study Group ◽

Media Thickness ◽

Hypertension In Children

Hypertension is a major risk factor for progression of the atherosclerotic process and for developing of degenerative cardiovascular diseases in adulthood. The aim of this study is to evaluate how the measurement of carotid intima - media thickness for prediction of essential hypertension in children can be used.The study group included 81 children and the control group 61 children, all aged between 5 - 17 years and 11 months old, and admitted in Children Hospital Brasov in the period of 2009 � 2014. The study protocol included: BMI, blood pressure and Doppler echography of the common carotid artery for each group. Mean age of the patients from the study group was 13.67 years, 43.20 % girls and 56.80 % boys, while in the control group, the mean age was 14.07 years, 54.10% girls and 45.90 % boys. 70.37% of the children from the study group presented obesity, while in the control group 40.98% were obese. The IMTC study group ranged from 0.52 - 0.69 mm and the limits of the normotensive subjects were 0.32 -0.54 mm. In both groups the obese patients were found to have increased carotid artery intima-media, which means that IMTC was positively correlated with BMI (p=0.000001).It is necessary to identify diagnostic methods easily applicable for children, allowing involvement of the characteristics of the arterial wall in the degenerative pathological processes. Increased intima-media ratio is positively correlated with high values of blood pressure.

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Angiotensinogen Gene M235T and T174M Polymorphisms in Essential Hypertension Relation With Target Organ Damage

American Journal of Hypertension ◽

10.1016/s0895-7061(97)00483-4 ◽

1998 ◽

Vol 11 (4) ◽

pp. 439-444 ◽

Cited By ~ 22

Author(s):

P Fernández-Llama

Keyword(s):

Essential Hypertension ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Angiotensinogen Gene

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The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage

Journal of Human Hypertension ◽

10.1038/sj.jhh.1001810 ◽

2005 ◽

Vol 19 (3) ◽

pp. 211-217 ◽

Cited By ~ 21

Author(s):

C Tsioufis ◽

D Chatzis ◽

E Vezali ◽

K Dimitriadis ◽

D Antoniadis ◽

...

Keyword(s):

Uric Acid ◽

Essential Hypertension ◽

Serum Uric Acid ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ

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Relationships between 24 h blood pressure load and target organ damage in patients with mild-to-moderate essential hypertension

Blood Pressure Monitoring ◽

10.1097/00126097-200106000-00001 ◽

2001 ◽

Vol 6 (3) ◽

pp. 115-123 ◽

Cited By ~ 28

Author(s):

Giuseppe Mulè ◽

Emilio Nardi ◽

Giuseppe Andronico ◽

Santina Cottone ◽

Francesco Raspanti ◽

...

Keyword(s):

Blood Pressure ◽

Essential Hypertension ◽

Target Organ Damage ◽

Organ Damage ◽

Moderate Essential Hypertension ◽

Target Organ ◽

Pressure Load ◽

Blood Pressure Load

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Essential hypertension: Diagnosis, assessment, and treatment

Oxford Textbook of Medicine ◽

10.1093/med/9780198746690.003.0378 ◽

2020 ◽

pp. 3753-3778

Author(s):

Bryan Williams ◽

John D. Firth

Keyword(s):

Blood Pressure ◽

Essential Hypertension ◽

Severe Hypertension ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Elevated Blood ◽

Hypertensive Patients ◽

Assessment And Treatment ◽

Hypertension Diagnosis

Essential hypertension is invariably symptomless and usually detected by routine screening or opportunistic measurement of blood pressure. However, once a patient has been labelled as ‘hypertensive’ it is not uncommon for them to associate preceding symptoms to their elevated blood pressure. Some patients will claim that they can recognize when their blood pressure is elevated, usually on the basis of symptoms such as plethoric features, palpitations, dizziness, or a feeling of tension. Screening surveys have demonstrated that these symptoms occur no more commonly in untreated hypertensive patients than they do in the normotensive population. However, there are two important caveats to the symptomless nature of essential hypertension: (1) symptoms may develop as a consequence of target organ damage, (2) headache may be a feature of severe hypertension.

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