scholarly journals Carotid intima-media thickness as a target-organ damage and treatment-target: Need for a major revision?

2018 ◽  
Vol 20 (2) ◽  
pp. 255-257 ◽  
Author(s):  
Konstantinos Stavropoulos ◽  
Konstantinos P. Imprialos ◽  
Michael Doumas ◽  
Vasilios G. Athyros
Keyword(s):  
Target Organ Damage ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Organ Damage ◽  
Target Organ ◽  
Treatment Target ◽  
Media Thickness ◽  
Major Revision

scholarly journals Protocol for Measuring Carotid Intima-Media Thickness That Best Correlates With Cardiovascular Risk and Target Organ Damage

2012 ◽  
Vol 25 (9) ◽  
pp. 955-961 ◽  
Author(s):  
Manuel A. Gómez-Marcos ◽  
José I. Recio-Rodríguez ◽  
María C. Patino-Alonso ◽  
Cristina Agudo-Conde ◽  
Leticia Gómez-Sanchez ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Target Organ Damage ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Organ Damage ◽  
Target Organ ◽  
Media Thickness

scholarly journals 3044Exploration of biomarkers for subclinical atherosclerosis in an African population using a proteomics chip targeted at inflammation and cardiovascular disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Jujic ◽  
L Malan ◽  
C Mels ◽  
P M Nilsson ◽  
M Magnusson
Keyword(s):  
Blood Pressure ◽  
Subclinical Atherosclerosis ◽  
Target Organ Damage ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Organ Damage ◽  
Target Organ ◽  
African Population ◽  
Carotid Ultrasound ◽  
North West

Abstract Introduction The evolving use of multiplex proteomic platforms provides an excellent tool for investigating associations between multiple proteins and subclinical atherosclerotic disease. In this study, we evaluated the impact of a multiplex protein panel, on carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis. Purpose We used a multiplex proteomic platform to identify possible associations between proteins and subclinical carotid atherosclerosis as measured by carotid ultrasound in an African population. Methods In the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study, 92 proteins from the Proseek Multiplex CVD III 96×96 (Olink Bioscience, Sweden) were analyzed in 378 participants (mean age 44.7±9.6 years, 50.6% women, 10.8% with known cardiovascular disease). Carotid ultrasound was performed for measurements of the carotid intima-media thickness (cIMT, mean 0.663±0.127 mm) and calculation of cross-sectional wall area (CSWA, mean 13.5±4.4mm2), a measure of target organ damage. Possible associations between the proteins, and cIMT and CSWA, respectively, were explored using linear regression models. A two-sided Bonferroni corrected P-value of 0.05/92=5.4x10–4 was considered statistically significant in the crude analysis. Results Of 18 proteins (1 standard deviation of change of ln-transformed values) that were Bonferroni-corrected (p≤5.4x10–4) significantly associated with cIMT and/or CWAS in crude analyses, the following remained significant after further adjustment for age, sex, waist circumference, systolic blood pressure, smoking and total cholesterol: growth-differentiation factor-15 (GDF15; β 0.017, p=0.050), E-selectin (SELE; β 0.019, p=0.017), carboxypeptidase A1 (CPA1; β 0.019, p=0.019), C-C motif chemokine 15 (CCL15; β 0.031, p<0.001), chitinase-3-like protein 1 (CHI3L1; β 0.021, p=0.007), the hemoglobin scavenger receptor (CD163; β 0.021, p=0.008) and osteoprotegerin (OPG; β 0.022, p=0.004). As for target-organ damage defined by CSWA, SELE (β 0.459, p=0.018), CCL15 (β 0.398; p=0.032) and CD163 (β 0.541, p=0.005) showed multivariate adjusted significant associations. Conclusion In an African population, we could confirm five proteins (GDF15, SELE, CHI3L1, CD163 and OPG) associated with cIMT, but in addition identified two proteins (CPA1 and CCL15) with novel associations with cIMT and/or CSWA. Acknowledgement/Funding North-West University; National Research Foundation (NRF); Medical Research Council (MRC-SA); Department of Education North-West Province; ROCHE

scholarly journals Subclinical vessel lesion in normotensive patients with abdominal obesity: focus on arterial stiffness

2013 ◽  
Vol 10 (2) ◽  
pp. 46-52
Author(s):  
M A Druzhilov ◽  
V V Otmakhov ◽  
Yu E Beteleva ◽  
V A Korneva ◽  
T Yu Kuznetsova
Keyword(s):  
Arterial Stiffness ◽  
Abdominal Obesity ◽  
Target Organ Damage ◽  
Intima Media Thickness ◽  
Organ Damage ◽  
Target Organ ◽  
Threshold Values ◽  
Arterial Lesion ◽  
Cardio Vascular

Aim: assessment of arterial stiffness (AS) in patients with abdominal obesity (AO) without arterial hypertension and low cardio-vascular risk (CVR), the analysis of AS correlation with the markers of target organ remodeling, determination of threshold values AS, combined with a high probability target organ damage. Subjects and methods. 95 normotensive patients with AO were examined (mean age 44,9±5,1 years, 72 men) by following methods: lipid and glucose level, carotid artery ultrasound with intima/media thickness estimation, echocardiography, 24-hour monitoring of blood pressure (BP) with arterial stiffness assessment, obtained by the portable recorder BPLab. Results. Subclinical arterial lesion was revealed in 37,9%, mean pulse wave velocity (PWV) was 7,6±0,6 m/s, maximum PWV – 10 m/s. PWV and central BP in aorta were higher in patients with subclinical carotid atherosclerosis (8,0±0,5 m/s vs 7,5±0,6 m/s, р

A predictive marker for target organ damage in primary hypertension: serum uric acid levels

2021 ◽  
pp. 31-36
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Robust Regression ◽  
Target Organ Damage ◽  
Predictive Marker ◽  
Intima Media Thickness ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Primary Hypertension

Background: This study aims to investigate the relationship between serum uric acid levels, the left ventricular mass index (LVMI), and carotid intima-media thickness (CIMT) in primary hypertension patients. Material and Method: A total of 139 primary hypertension patients, including 45 (32.4%) men and 94 (67.6%) women were involved in the study. The laboratory and clinical demographic findings, as well as the LVMI and CIMT levels of the patients, were collected from patient files. Results: 37% of the study population were found to have hyperuricemia. LVMI (99.75}13.4 vs 86.17±17.6; p=0.010) and CIMT (0.88±0.26 vs 0.75±0.17; p=0.023) levels were found to be higher in the hyperuricemia versus the non-hyperuricemia group. According to the correlation analysis, there was a positive correlation between uric acid and LVMI (r=0.282, p=0.032) and CIMT (r=0.285, p=0.002) levels. Robust regression analysis showed that uric acid was an independent risk factor for both the LVMI (β±SE: 1.615±1.03, p<0.05) and CIMT (β±SE: 0.251±0.09, p<0.05). Conclusion: We found serum uric acid levels to be closely related to the target organ damage associated with primary hypertension, and even related with target organ damage independent from blood pressure.

Blood pressure monitoring in kidney transplantation: a systematic review on hypertension and target organ damage

2021 ◽  
Author(s):  
Anna Pisano ◽  
Francesca Mallamaci ◽  
Graziella D’Arrigo ◽  
Davide Bolignano ◽  
Gregoire Wuerzner ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Target Organ Damage ◽  
Intima Media Thickness ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Kidney Transplant Recipients ◽  
Pressure Monitoring

Abstract Background Sparse studies show that ambulatory blood pressure monitoring (ABPM) is superior to office BP (oBP) measurements to predict target organ damage and cardiovascular (CV) events in kidney transplant recipients (KTRs). We performed a systematic review aimed at determining the potential associations between BP recordings by different methods and renal and CV outcomes in this population. Methods Major medical databases were searched for studies enrolling adult KTRs undergoing 24h ABPM compared to office or home BP measurements. Main outcomes were: associations between different BP recordings and renal and CV outcomes. Additionally, any association between the circadian BP pattern (dipping/non-dipping status) and outcomes was assessed. Results Twenty-two studies (2078 participants) were reviewed. Amongst 12 studies collecting data on renal endpoints, ten studies found that BP assessed by ABPM was a stronger predictor of renal function decline, assessed by serum creatinine (SCr) and/or creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR), than traditional office measurements. Twelve studies analyzed the relation between different BP recordings and CV target organ damages and reported robust correlations between echocardiographic abnormalities [i.e. left ventricular mass index (LVM/LVMI)] and 24h ABPM, but not with office BPs. Furthermore, 24h ABPM correlated better than oBP with markers of vascular damage, such as carotid intima-media thickness (IMT), diffuse thickening, and endothelial dysfunction. Additionally, abnormal circadian BP pattern (non-dippers and reverse dippers) identified a group of kidney recipients at risk for kidney function loss and CV abnormalities. Conclusions In our systematic review, ABPM reflected target organ damage more closely than oBP in KTRs. Furthermore, altered circadian BP profile associated with renal and CV target organ damages.

Sign in / Sign up

Export Citation Format

Share Document