scholarly journals Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Tien-Jyun Chang ◽  
Yen-Feng Chiu ◽  
Wayne H-H. Sheu ◽  
Kuang-Chung Shih ◽  
Chii-Min Hwu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Polymorphisms ◽  
Glucose Homeostasis ◽  
Chinese Population

scholarly journals Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population

Diabetes ◽  
2007 ◽  
Vol 56 (10) ◽  
pp. 2631-2637 ◽  
Author(s):  
Y.-C. Chang ◽  
T.-J. Chang ◽  
Y.-D. Jiang ◽  
S.-S. Kuo ◽  
K.-C. Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Association Study ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Tcf7l2 Gene

scholarly journals Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population

2013 ◽  
Vol 12 (3) ◽  
pp. 3813-3820 ◽  
Author(s):  
X.D. Fu ◽  
X.Q. Sun ◽  
H.Y. Wang ◽  
J.F. Guo ◽  
G.Z. Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Tlr4 Gene

Evaluation of the association between the PPARGC1A genetic polymorphisms and type 2 diabetes in Han Chinese population

2009 ◽  
Vol 86 (3) ◽  
pp. 168-172 ◽  
Author(s):  
Shuying Zhu ◽  
Yang Liu ◽  
Xin Wang ◽  
Xiaopan Wu ◽  
Xilin Zhu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population

2016 ◽  
Vol 15 (3) ◽  
Author(s):  
Q.Y. Dong ◽  
X.M. Liu ◽  
C.G. Liang ◽  
W.H. Du ◽  
Y.L. Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Polymorphisms ◽  
Chinese Population

scholarly journals Association of genetic polymorphisms of SelS with Type 2 diabetes in a Chinese population

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Long Zhao ◽  
Ying-Ying Zheng ◽  
You Chen ◽  
Yi-Tong Ma ◽  
Yi-Ning Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
The Difference ◽  
The Relationship ◽  
Control Study

Background: Selenoprotein S (SelS) gene expression is positively correlated to triglyceride (TG) concentrations and is associated with diabetes in animal model. However, the relationship between genetic polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. Methods: In the present study, we genotyped four single nucleotide polymorphisms (rs12910524, rs1384565, rs2101171, rs4965814) of SelS gene using TaqMan genotyping method in a case–control study (1947 T2DM patients and 1639 control subjects). Results: We found both rs1384565 CC genotype (12.1 compared with 6.6%, P<0.001) and C allele (35.2 compared with 24.4%, P<0.001) were more frequent in the T2DM patients than in the controls. Logistic regression analysis suggested after adjustment of other confounders, the difference remained significant between the two groups (CC compared with TT, P=0.002, OR = 1.884, 95% CI: 1.263–2.811; CT compared with TT, P<0.001, OR = 1.764, 95% CI: 1.412–2.204). Conclusion: The present study suggested that genetic polymorphisms of SelS were associated with T2DM in a Chinese population.

Pharmacological Neprilysin Inhibition Improves Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1825-P ◽  
Author(s):  
JACQUELINE H. PARILLA ◽  
STEVE MONGOVIN ◽  
BREANNE BARROW ◽  
NATHALIE ESSER ◽  
SAKENEH ZRAIKA
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Model ◽  
Glucose Homeostasis ◽  
Neprilysin Inhibition
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