scholarly journals RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation

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Multi-purpose drug suramin is found to be active against cancer-related Wnt signalling. As a consequence of heterotrimeric G proteins suppression, suramin inhibits Wnt ligand internalization, which renders the drug active against triple-negative breast cancer (TNBC).


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