scholarly journals Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Bankala Krishnarjuna ◽  
Dean Andrew ◽  
Christopher A. MacRaild ◽  
Rodrigo A. V. Morales ◽  
James G. Beeson ◽  
...  
2000 ◽  
Vol 68 (5) ◽  
pp. 3019-3022 ◽  
Author(s):  
Peter Vukovic ◽  
P. Mark Hogarth ◽  
Nadine Barnes ◽  
David C. Kaslow ◽  
Michael F. Good

ABSTRACT Merozoite surface protein 1 (MSP-119) is a leading malaria vaccine candidate. Specific antibodies contribute to immunity; binding to macrophages is believed to represent the main action of malaria antibodies. We show that an MSP-119-specific immunoglobulin G3 (IgG3) monoclonal antibody can passively transfer protection to mice deficient in the α chain of Fc-γRI whose macrophages cannot bind IgG3.


PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0146951 ◽  
Author(s):  
Rodrigo Nunes Rodrigues-da-Silva ◽  
João Hermínio Martins da Silva ◽  
Balwan Singh ◽  
Jianlin Jiang ◽  
Esmeralda V. S. Meyer ◽  
...  

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