scholarly journals Association between bilirubin and risk of Non-Alcoholic Fatty Liver Disease based on a prospective cohort study

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jianbo Tian ◽  
Rong Zhong ◽  
Cheng Liu ◽  
Yuhan Tang ◽  
Jing Gong ◽  
...  
2021 ◽  
Vol 40 (10) ◽  
pp. 5373-5382
Author(s):  
Shunming Zhang ◽  
Yeqing Gu ◽  
Shanshan Bian ◽  
Magdalena J. Górska ◽  
Qing Zhang ◽  
...  

BMJ ◽  
2011 ◽  
Vol 343 (nov18 2) ◽  
pp. d6891-d6891 ◽  
Author(s):  
M. Lazo ◽  
R. Hernaez ◽  
S. Bonekamp ◽  
I. R. Kamel ◽  
F. L. Brancati ◽  
...  

2011 ◽  
Vol 96 (7) ◽  
pp. 669-674 ◽  
Author(s):  
B. G. P. Koot ◽  
O. H. van der Baan-Slootweg ◽  
C. L. J. Tamminga-Smeulders ◽  
T. H. P. Rijcken ◽  
J. C. Korevaar ◽  
...  

2018 ◽  
Vol 154 (6) ◽  
pp. S-1171-S-1172
Author(s):  
Julalak Karuehardsuwan ◽  
Roongruedee Chaiteerakij ◽  
Panida Piyachaturawat ◽  
Kanokwan Sonsiri ◽  
Chonlada Phathong ◽  
...  

2021 ◽  
Vol 8 ◽  
Author(s):  
Ahmed Abdel-Razik ◽  
Nasser Mousa ◽  
Walaa Shabana ◽  
Ahmed H. Yassen ◽  
Mostafa Abdelsalam ◽  
...  

Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD.Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined.Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P < 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P < 0.001) at cutoff values of > 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P < 0.001) at cutoff values of >7.5.Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis.


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