Stability constants of α-cyclodextrin complexes of para-substituted aromatic ketones in aqueous solution

The purpose of our work was to examine the metal binding abilities of selected peptide bound Maillard reaction products (MRPs). The Nα-hippuryl-protected MRPs Nε-fructoselysine and Nε-carboxymethyllysine were synthesised and measurement of stability constants for complexes formed with the physiologically important metal ions copper(II) and zinc(II) was carried out in aqueous solution (T = 298.1 K; I = 0.1M KNO3) using pH-potentiometry. The stability constants of Nε-fructoselysine and Nε-carboxymethyllysine with Cu(II) proved that new coordination centres are formed by the nonenzymatic glycation of proteins. With zinc(II) no complexation was observed. Physiological consequences are discussed, but further studies are necessary in order to clarify the effects of this phenomenon.

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Stability constants for some transition metal complexes of adenosine and 9-(β-D-ribofuranosyl)purine in aqueous solution

Inorganica Chimica Acta ◽

10.1016/s0020-1693(00)90779-5 ◽

1981 ◽

Vol 55 ◽

pp. 39-42 ◽

Cited By ~ 21

Author(s):

Harri Lönnberg ◽

Jorma Arpalahti

Keyword(s):

Aqueous Solution ◽

Transition Metal ◽

Metal Complexes ◽

Stability Constants ◽

Transition Metal Complexes

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Novel Polymerization of Fluorinated 2-Vinylcyclopropane in Aqueous Solution via Cyclodextrin Complexes

Macromolecular Chemistry and Physics ◽

10.1002/macp.200350010 ◽

2003 ◽

Vol 204 (12) ◽

pp. 1475-1479 ◽

Cited By ~ 18

Author(s):

Soo Whan Choi ◽

Oliver Kretschmann ◽

Helmut Ritter ◽

Marina Ragnoli ◽

Giancarlo Galli

Keyword(s):

Aqueous Solution ◽

Cyclodextrin Complexes

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Complexation of Fluorinated Amino Acid Derivatives by β- and γ-Cyclodextrin in Aqueous Solution. A 19F Nuclear Magnetic Resonance Study

Australian Journal of Chemistry ◽

10.1071/ch9950505 ◽

1995 ◽

Vol 48 (3) ◽

pp. 505 ◽

Cited By ~ 3

Author(s):

SE Brown ◽

CJ Easton ◽

SF Lincoln

Keyword(s):

Aqueous Solution ◽

Amino Acid ◽

Nuclear Magnetic Resonance Study ◽

Amino Acid Derivatives ◽

Magnetic Resonance Study ◽

Cyclodextrin Complexes ◽

Factors Affecting ◽

Chemical Shift Data ◽

Shift Data ◽

Insight Into

A 19F n.m.r. study shows that the β-cyclodextrin complexes of deprotonated α-(p- fluorophenyl ) glycine, N-acetyl-α-(p- fluorophenyl ) glycine , deprotonated N-acetyl-α-(p- fluorophenyl ) glycine , and N-(p- fluorobenzoyl ) valine are characterized by stability constants KR/dm3 mol-1 and Ks/dm3 mol-1 =13�2 and 21�3, 34�1 and 35�2, 12�1 and 12� 1, and 84�2 and 93�2, respectively, where the first and second of each pair of values refers to the complex formed by the R and S enantiomers of the fluorinated amino acid derivatives, respectively, in 10% aqueous D2O solution at 295.5 K and I = 0.10 mol dm-3. A comparison of these data and the associated 19F chemical shift data with those for the analogous α- and γ- cyclodextrin complexes provides an insight into the factors affecting the stabilities and structures of these complexes.

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Polarographic Study of the Complexation of Na+ and K+ Ions by Dibenzo-18-crown-6 in Non-Aqueous Solution

Australian Journal of Chemistry ◽

10.1071/ch9902003 ◽

1990 ◽

Vol 43 (12) ◽

pp. 2003 ◽

Cited By ~ 3

Author(s):

E Lada ◽

A Urbanczyk ◽

MK Kalinowski

Keyword(s):

Aqueous Solution ◽

Stability Constants ◽

Polarographic Study

Complexes of Na+ and K+ ions with dibenzo-18-crown-6 (6,7,9,10,17,18,20,21-octahydro-dibenzo[ b,k ] [1,4,7,10,13,16] hexaoxacyclooctadecin ) were studied by polarography in several non-proton-donating media. Their stability constants are strongly influenced by the solvents, and vary inversely with the Gutmann donicity scale and with the Persson HDS parameter which is a measure of the hardness for these solvents.

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