DNA cleavage in red light promoted by copper(ii) complexes of α-amino acids and photoactive phenanthroline bases

2008 ◽  
pp. 6966 ◽  
Author(s):  
Ashis K. Patra ◽  
Tuhin Bhowmick ◽  
Suryanarayanarao Ramakumar ◽  
Munirathinam Nethaji ◽  
Akhil R. Chakravarty
Keyword(s):  
Amino Acids ◽  
Dna Cleavage ◽  
Red Light ◽  
Phenanthroline Bases

Anaerobic DNA cleavage activity in red light and photocytotoxicity of (pyridine-2-thiol)cobalt(iii) complexes of phenanthroline bases

2010 ◽  
Vol 39 (7) ◽  
pp. 1807 ◽  
Author(s):  
Debojyoti Lahiri ◽  
Sovan Roy ◽  
Sounik Saha ◽  
Ritankar Majumdar ◽  
Rajan R. Dighe ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Red Light ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Phenanthroline Bases

DNA Cleavage by New Oxovanadium(IV) Complexes ofN-Salicylidene α-Amino Acids and Phenanthroline Bases in the Photodynamic Therapy Window

2007 ◽  
Vol 46 (26) ◽  
pp. 11112-11121 ◽  
Author(s):  
Pijus K. Sasmal ◽  
Ashis K. Patra ◽  
Munirathinam Nethaji ◽  
Akhil R. Chakravarty
Keyword(s):  
Amino Acids ◽  
Photodynamic Therapy ◽  
Dna Cleavage ◽  
Phenanthroline Bases

scholarly journals Correction to Copper(II) Complexes of l-Arginine as Netropsin Mimics Showing DNA Cleavage Activity in Red Light

2019 ◽  
Vol 58 (19) ◽  
pp. 13502-13503
Author(s):  
Ashis K. Patra ◽  
Tuhin Bhowmick ◽  
Sovan Roy ◽  
Suryanarayanarao Ramakumar ◽  
Akhil R. Chakravarty
Keyword(s):  
Dna Cleavage ◽  
Red Light ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals A Domain of Herpes Simplex Virus pUL33 Required To Release Monomeric Viral Genomes from Cleaved Concatemeric DNA

2017 ◽  
Vol 91 (20) ◽  
Author(s):  
Kui Yang ◽  
Xiaoqun Dang ◽  
Joel D. Baines
Keyword(s):  
Amino Acids ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Viral Replication ◽  
Dna Cleavage ◽  
Artificial Chromosome ◽  
Viral Dna ◽  
Viral Genomes ◽  
C Terminus ◽  
Simplex Virus

ABSTRACT Monomeric herpesvirus DNA is cleaved from concatemers and inserted into preformed capsids through the actions of the viral terminase. The terminase of herpes simplex virus (HSV) is composed of three subunits encoded by UL15, UL28, and UL33. The UL33-encoded protein (pUL33) interacts with pUL28, but its precise role in the DNA cleavage and packaging reaction is unclear. To investigate the function of pUL33, we generated a panel of recombinant viruses with either deletions or substitutions in the most conserved regions of UL33 using a bacterial artificial chromosome system. Deletion of 11 amino acids (residues 50 to 60 or residues 110 to 120) precluded viral replication, whereas the truncation of the last 10 amino acids from the pUL33 C terminus did not affect viral replication or the interaction of pUL33 with pUL28. Mutations that replaced the lysine at codon 110 and the arginine at codon 111 with alanine codons failed to replicate, and the pUL33 mutant interacted with pUL28 less efficiently. Interestingly, genomic termini of the large (L) and small (S) components were detected readily in cells infected with these mutants, indicating that concatemeric DNA was cleaved efficiently. However, the release of monomeric genomes as assessed by pulsed-field gel electrophoresis was greatly diminished, and DNA-containing capsids were not observed. These results suggest that pUL33 is necessary for one of the two viral DNA cleavage events required to release individual genomes from concatemeric viral DNA. IMPORTANCE This paper shows a role for pUL33 in one of the two DNA cleavage events required to release monomeric genomes from concatemeric viral DNA. This is the first time that such a phenotype has been observed and is the first identification of a function of this protein relevant to DNA packaging other than its interaction with other terminase components.

scholarly journals Correction to Metal-Based Netropsin Mimics Showing AT-Selective DNA Binding and DNA Cleavage Activity at Red Light

2019 ◽  
Vol 58 (14) ◽  
pp. 9514-9514
Author(s):  
Ashis K. Patra ◽  
Tuhin Bhowmick ◽  
Suryanarayanarao Ramakumar ◽  
Akhil R. Chakravarty
Keyword(s):  
Dna Binding ◽  
Dna Cleavage ◽  
Red Light ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Selective Dna Binding

Synthesis and DNA cleavage properties of ternary Cu(II) complexes containing histamine and amino acids

2006 ◽  
Vol 47 (41) ◽  
pp. 7311-7315 ◽  
Author(s):  
Pulimamidi Rabindra Reddy ◽  
Kandibanda Srinivasa Rao ◽  
Battu Satyanarayana
Keyword(s):  
Amino Acids ◽  
Dna Cleavage

Photocytotoxicity and DNA cleavage activity of l-arg and l-lys Schiff base oxovanadium(iv) complexes having phenanthroline bases

2010 ◽  
Vol 39 (30) ◽  
pp. 7104 ◽  
Author(s):  
Pijus K. Sasmal ◽  
Ritankar Majumdar ◽  
Rajan R. Dighe ◽  
Akhil R. Chakravarty
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Phenanthroline Bases

Photosensitized DNA cleavage promoted by amino acids

2003 ◽  
pp. 1956-1957 ◽  
Author(s):  
Kerry P. Mahon, Jr. ◽  
Rodrigo F. Ortiz-Meoz ◽  
Erin G. Prestwich ◽  
Shana O. Kelley
Keyword(s):  
Amino Acids ◽  
Dna Cleavage

scholarly journals A Comparison of β-Carotene, Phytoene and Amino Acids Production in Dunaliella salina DF 15 (CCAP 19/41) and Dunaliella salina CCAP 19/30 Using Different Light Wavelengths

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2824
Author(s):  
Yixing Sui ◽  
Laura Mazzucchi ◽  
Parag Acharya ◽  
Yanan Xu ◽  
Geraint Morgan ◽  
...  
Keyword(s):  
Amino Acids ◽  
Blue Light ◽  
Dunaliella Salina ◽  
Protein Quality ◽  
Monosodium Glutamate ◽  
Red Light ◽  
Dry Weight ◽  
Essential Amino Acids ◽  
Valuable Compounds ◽  
Β Carotene

Strains of Dunaliella salina microalgae are of considerable research and industrial interest because they hyper-accumulate β-carotene as well as produce high-quality protein. To explore the co-production of valuable compounds in D. salina, this study compared the production of β-carotene, phytoene and amino acids in two strains cultivated under white, red or blue light until no further nitrogen was available. D. salina DF15 (CCAP 19/41 (PLY DF15)) produced more than 12% β-carotene (ash-free dry weight (AFDW) basis), and red light triggered the production of 9-cis β-carotene at a 9-cis/all-trans β-carotene ratio of 1.5. Phytoene production was also evident in D. salina DF15 under all conditions, particularly under blue light. However, the profile of essential amino acids (EAAs) and calculation of the essential amino acid index (EAAI) was less than ideal in terms of protein quality, for both strains. Umami compounds, quantified as monosodium glutamate (MSG) equivalents, indicated a higher equivalent umami concentration (EUC) in D. salina DF15 under red light (3.2 g MSG/100 g AFDW) than in D. salina CCAP19/30. Overall, D. salina DF15 demonstrates valuable traits for further exploration and product optimisation.

scholarly journals Anaerobic DNA cleavage in red light by dicopper(II) complexes on disulphide bond activation

2010 ◽  
Vol 122 (3) ◽  
pp. 321-333 ◽  
Author(s):  
Debojyoti Lahiri ◽  
Ritankar Majumdar ◽  
Ashis K. Patra ◽  
Akhil R. Chakravarty
Keyword(s):  
Dna Cleavage ◽  
Bond Activation ◽  
Red Light ◽  
Disulphide Bond
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