scholarly journals Combination approaches to potentiate immune response after photodynamic therapy for cancer

2011 ◽  
Vol 10 (5) ◽  
pp. 792 ◽  
Author(s):  
Tyler G. St. Denis ◽  
Kanza Aziz ◽  
Anam A. Waheed ◽  
Ying-Ying Huang ◽  
Sulbha K. Sharma ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy

Immune Response Against Angiosarcoma Following Lower Fluence Rate Clinical Photodynamic Therapy

2008 ◽  
Vol 27 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Patricia S.P. Thong ◽  
Malini Olivo ◽  
Kiang-Wei Kho ◽  
Ramaswamy Bhuvaneswari ◽  
William W. L. Chin ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Fluence Rate

scholarly journals Artificial Cell-Mediated Photodynamic Therapy Enhanced Anticancer Efficacy through Combination of Tumor Disruption and Immune Response Stimulation

ACS Omega ◽  
2019 ◽  
Vol 4 (7) ◽  
pp. 12727-12735 ◽  
Author(s):  
Jiang Ni ◽  
Ying Sun ◽  
Jinfang Song ◽  
Yiqing Zhao ◽  
Qiufang Gao ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Anticancer Efficacy ◽  
Artificial Cell

Stimulation of the host immune response by photodynamic therapy (PDT)

2004 ◽  
Author(s):  
Sandra O. Gollnick ◽  
Edith Kabingu ◽  
Philaretos C. Kousis ◽  
Barbara W. Henderson
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Host Immune Response ◽  
Stimulation Of

scholarly journals Photodynamic Therapy Using a New Folate Receptor-Targeted Photosensitizer on Peritoneal Ovarian Cancer Cells Induces the Release of Extracellular Vesicles with Immunoactivating Properties

2020 ◽  
Vol 9 (4) ◽  
pp. 1185 ◽  
Author(s):  
Martha Baydoun ◽  
Olivier Moralès ◽  
Céline Frochot ◽  
Colombeau Ludovic ◽  
Bertrand Leroux ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune Response ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Extracellular Vesicles ◽  
Immune Cells ◽  
Surgical Techniques ◽  
Ovarian Cancer Cells ◽  
The Impact

Often discovered at an advanced stage, ovarian cancer progresses to peritoneal carcinoma, which corresponds to the invasion of the serosa by multiple tumor implants. The current treatment is based on the combination of chemotherapy and tumor cytoreduction surgery. Despite the progress and standardization of surgical techniques combined with effective chemotherapy, post-treatment recurrences affect more than 60% of women in remission. Photodynamic therapy (PDT) has been particularly indicated for the treatment of superficial lesions on large surfaces and appears to be a relevant candidate for the treatment of microscopic intraperitoneal lesions and non-visible lesions. However, the impact of this therapy on immune cells remains unclear. Hence, the objective of this study is to validate the efficacy of a new photosensitizer [pyropheophorbide a-polyethylene glycol-folic acid (PS)] on human ovarian cancer cells and to assess the impact of the secretome of PDT-treated cells on human peripheral blood mononuclear cells (PBMC). We show that PS, upon illumination, can induce cell death of different ovarian tumor cells. Furthermore, PDT using this new PS seems to favor activation of the immune response by inducing the secretion of effective cytokines and inhibiting the pro-inflammatory and immunosuppressive ones, as well as releasing extracellular vesicles (EVs) prone to activating immune cells. Finally, we show that PDT can activate CD4+ and CD8+ T cells, resulting in a potential immunostimulating process. The results of this pilot study therefore indicate that PS-PDT treatment may not only be effective in rapidly and directly destroying target tumor cells but also promote the activation of an effective immune response; notably, by EVs. These data thus open up good prospects for the treatment of micrometastases of intraperitoneal ovarian carcinosis which are currently inoperable.

scholarly journals Photodynamic Therapy Can Induce a Protective Innate Immune Response against Murine Bacterial Arthritis via Neutrophil Accumulation

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39823 ◽  
Author(s):  
Masamitsu Tanaka ◽  
Pawel Mroz ◽  
Tianhong Dai ◽  
Liyi Huang ◽  
Yuji Morimoto ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Neutrophil Accumulation ◽  
Bacterial Arthritis
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